USP10 and SCNN1G

Number of citations of the paper that reports this interaction (PubMedID 18632802)
20

Data Source:
HPRD (in vivo)

		USP10	SCNN1G
Description		ubiquitin specific peptidase 10	sodium channel epithelial 1 subunit gamma
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Early Endosome Cytosol Protein-containing Complex	Nucleoplasm Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Apical Plasma Membrane Sodium Channel Complex Extracellular Exosome
	Molecular Function	P53 Binding RNA Binding Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Thiol-dependent Ubiquitinyl Hydrolase Activity Ion Channel Binding	Ion Channel Activity Sodium Channel Activity Protein Binding Ligand-gated Sodium Channel Activity WW Domain Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Autophagy Cellular Response To DNA Damage Stimulus Regulation Of Autophagy Protein Deubiquitination Translesion Synthesis DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Response To Interleukin-1	Sodium Ion Transport Excretion Ion Transmembrane Transport Sodium Ion Transmembrane Transport Multicellular Organismal Water Homeostasis Response To Stimulus Sensory Perception Of Taste Sodium Ion Homeostasis
Pathways		Termination of translesion DNA synthesis Ub-specific processing proteases	Stimuli-sensing channels
Drugs			Triamterene Amiloride
Diseases			Liddle syndrome Hyperkalemic distal renal tubular acidosis (RTA type 4), including the following two diseases: Pseudohypoaldosteronism type I (PHA1); Pseudohypoaldosteronism type II (Gordon's syndrome) Bronchiectasis with or without elevated sweat chloride
GWAS		Copper levels ( 26025379) Height ( 18391951) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Plasma factor VII activating protease levels ( 30070759) Response to mTOR inhibitor (everolimus) ( 24009623) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252)	Heel bone mineral density ( 30598549)
Interacting Genes		13 interacting genes: AR G3BP1 H2AC20 IKBKG MSH2 NOTCH1 PRKAA2 RAD51 SCNN1A SCNN1G SIRT6 SNX3 UBC	13 interacting genes: COMMD10 EPN1 MAPK1 NEDD4 NEDD4L SCNN1A SCNN1B SCNN1D SERP1 SOX4 STX1A USP10 WWP2
Entrez ID		9100	6340
HPRD ID		07029	02862
Ensembl ID		ENSG00000103194	ENSG00000166828
Uniprot IDs		Q14694	A5X2V1 P51170
PDB IDs			6BQN
Enriched GO Terms of Interacting Partners?
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