SIRT6 and ELF5

Number of citations of the paper that reports this interaction (PubMedID 16189514)
1016

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SIRT6	ELF5
Description		sirtuin 6	E74 like ETS transcription factor 5
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Telomeric Heterochromatin Nucleolus Cytoplasm	Nuclear Chromatin Nucleus Cytoplasm
	Molecular Function	Chromatin Binding Transcription Corepressor Activity NAD+ ADP-ribosyltransferase Activity NAD(P)+-protein-arginine ADP-ribosyltransferase Activity Histone Deacetylase Activity Protein Binding Zinc Ion Binding NAD-dependent Histone Deacetylase Activity Deacetylase Activity NAD-dependent Protein Deacetylase Activity NAD-dependent Histone Deacetylase Activity (H3-K9 Specific) NAD+ Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Post-embryonic Cardiac Muscle Cell Growth Involved In Heart Morphogenesis Base-excision Repair Protein ADP-ribosylation Protein Deacetylation Negative Regulation Of Cell Proliferation Regulation Of Double-strand Break Repair Via Homologous Recombination Protein Destabilization Response To Nutrient Levels Positive Regulation Of Chromatin Silencing At Telomere Positive Regulation Of Telomere Maintenance Glucose Homeostasis Negative Regulation Of Glycolytic Process Negative Regulation Of Glucose Import Positive Regulation Of Fibroblast Proliferation Histone H3-K9 Modification Histone H3 Deacetylation Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Transcription Factor Catabolic Process Positive Regulation Of Chondrocyte Proliferation Positive Regulation Of Telomeric Heterochromatin Assembly Positive Regulation Blood Vessel Branching Positive Regulation Of Vascular Endothelial Cell Proliferation Histone H3-K9 Deacetylation Positive Regulation Of Stem Cell Proliferation	Ectodermal Cell Fate Commitment Regulation Of Transcription By RNA Polymerase II Cell Differentiation Somatic Stem Cell Population Maintenance Negative Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Mammary Gland Epithelial Cell Differentiation
Pathways		Pre-NOTCH Transcription and Translation Processing of DNA double-strand break ends
Drugs
Diseases
GWAS			β2-Glycoprotein I (β2-GPI) plasma levels ( 23279374) Blood protein levels ( 28240269) Metabolite levels ( 23823483)
Interacting Genes		17 interacting genes: AKT1 CCNDBP1 CDKN1B CHD3 ELF5 FAF1 HUS1 MUTYH RAD1 SKP2 STUB1 TDG TSPYL2 UBE2D1 UBE3A USP10 VIM	8 interacting genes: ACTR2 FRZB NFE2 NRIP2 RPS15A SIRT6 SS18L1 UBQLN4
Entrez ID		51548	2001
HPRD ID		12093	05525
Ensembl ID		ENSG00000077463	ENSG00000135374
Uniprot IDs		B4DDV3 M0QXA0 M0R1N9 Q8N6T7	A0A087X1W9 A8K443 Q9UKW6
PDB IDs		3K35 3PKI 3PKJ 3ZG6 5MF6 5MFP 5MFZ 5MGN 5X16 5Y2F 6HOY	1WWX
Enriched GO Terms of Interacting Partners?
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