PDE9A and TRIM32

Number of citations of the paper that reports this interaction (PubMedID 16189514)
1016

Data Source:
HPRD (two hybrid)

		PDE9A	TRIM32
Description		phosphodiesterase 9A	tripartite motif containing 32
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Golgi Apparatus Cytosol Ruffle Membrane Sarcolemma Perikaryon Perinuclear Region Of Cytoplasm	Cell Nucleus Cytoplasm Cytosol Striated Muscle Myosin Thick Filament
	Molecular Function	3',5'-cyclic-nucleotide Phosphodiesterase Activity Protein Binding Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity	Transcription Coactivator Activity RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Myosin Binding Tat Protein Binding Translation Initiation Factor Binding Identical Protein Binding Ubiquitin Binding Protein Self-association Ubiquitin Protein Ligase Activity
	Biological Process	Signal Transduction Positive Regulation Of Cardiac Muscle Hypertrophy CGMP-mediated Signaling CGMP Metabolic Process CGMP Catabolic Process	Protein Polyubiquitination Tissue Homeostasis Ubiquitin-dependent Protein Catabolic Process Actin Ubiquitination Response To UV Protein Ubiquitination Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Regulation Of Type I Interferon Production Negative Regulation Of Viral Transcription Response To Tumor Necrosis Factor Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Fat Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Protein Catabolic Process Positive Regulation Of Cell Cycle Positive Regulation Of Proteolysis Muscle Cell Cellular Homeostasis Negative Regulation Of Fibroblast Proliferation Positive Regulation Of Neurogenesis Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Striated Muscle Cell Differentiation Axon Development Negative Regulation Of Viral Release From Host Cell Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Interleukin-17-mediated Signaling Pathway Positive Regulation Of Chemokine (C-C Motif) Ligand 20 Production Positive Regulation Of Cell Motility
Pathways		cGMP effects	Regulation of innate immune responses to cytosolic DNA Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Caffeine Gamma-Glutamyl[S-(2-Iodobenzyl)Cysteinyl]Glycine 3-isobutyl-1-methyl-7H-xanthine Trapidil
Diseases			Bardet-Biedl syndrome (BBS)
GWAS		Perceived unattractiveness to mosquitoes ( 28199695)	Estimated glomerular filtration rate ( 31015462)
Interacting Genes		20 interacting genes: BAG3 C9orf106 CLK1 CRY2 GORASP2 KRTAP10-3 KRTAP10-8 KRTAP4-2 KRTAP9-2 LAGE3 LMO2 NAA38 NOTCH2NLA PCNT PHYHIPL SULT1E1 TFAP4 TRIM32 TRPV6 UTP23	41 interacting genes: ABI2 ATXN1 CLIP4 GLIS2 HSPA4 IQCB1 IRAK1 KCTD9 MID2 MYCN NDRG2 PDE9A PIAS3 PIAS4 PTCD2 PTPN11 RABAC1 RNF208 RNF41 SCGB1A1 SDCBP STING1 SYT6 TOP1 TRIM23 TRIM27 TRIM5 TRIM72 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2N UBE2U UBQLN1 UBQLN4 VPS11 XIAP
Entrez ID		5152	22954
HPRD ID		09115	03797
Ensembl ID		ENSG00000160191	ENSG00000119401
Uniprot IDs		A0A0S2Z475 A0A0S2Z4A3 A0A0S2Z4T6 O76083	A0A024R843 Q13049
PDB IDs		2HD1 2YY2 3DY8 3DYL 3DYN 3DYQ 3DYS 3JSI 3JSW 3K3E 3K3H 3N3Z 3QI3 3QI4 4E90 4G2J 4G2L 4GH6 4Y86 4Y87 4Y8C 6A3N	2CT2 5FEY
Enriched GO Terms of Interacting Partners?
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