CCN3 and FBLN1

Number of citations of the paper that reports this interaction (PubMedID 9927660)
48

Data Source:
HPRD (two hybrid, in vitro)

		CCN3	FBLN1
Description		cellular communication network factor 3	fibulin 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Gap Junction Axon Dendrite Extracellular Matrix Neuronal Cell Body Intracellular Membrane-bounded Organelle Collagen-containing Extracellular Matrix	Extracellular Region Basement Membrane Extracellular Space Extracellular Matrix Collagen-containing Extracellular Matrix Extracellular Exosome Elastic Fiber
	Molecular Function	Notch Binding Integrin Binding Protein Binding Insulin-like Growth Factor Binding Growth Factor Activity Heparin Binding	Fibronectin Binding Extracellular Matrix Structural Constituent Calcium Ion Binding Protein C-terminus Binding Peptidase Activator Activity Identical Protein Binding Protein-containing Complex Binding Fibrinogen Binding
	Biological Process	Angiogenesis Chondrocyte Differentiation Cell Adhesion Signal Transduction Regulation Of Gene Expression Fibroblast Migration Negative Regulation Of Myotube Differentiation Smooth Muscle Cell Migration Negative Regulation Of Cell Growth Cell Adhesion Mediated By Integrin Endothelial Cell Chemotaxis Type B Pancreatic Cell Proliferation Positive Regulation Of Notch Signaling Pathway Negative Regulation Of Insulin Secretion Smooth Muscle Cell Proliferation Negative Regulation Of Inflammatory Response Cell Chemotaxis Negative Regulation Of SMAD Protein Signal Transduction Negative Regulation Of Cell Death Hematopoietic Stem Cell Homeostasis Endothelial Cell-cell Adhesion Negative Regulation Of Monocyte Chemotaxis Negative Regulation Of NIK/NF-kappaB Signaling Negative Regulation Of Chondrocyte Proliferation Negative Regulation Of Sensory Perception Of Pain Bone Regeneration	Negative Regulation Of Protein Phosphorylation Negative Regulation Of Cell Adhesion Integrin-mediated Signaling Pathway Embryo Implantation Positive Regulation Of Peptidase Activity Viral Process Extracellular Matrix Organization Negative Regulation Of ERK1 And ERK2 Cascade Blood Coagulation, Fibrin Clot Formation Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Cell Motility Negative Regulation Of Stem Cell Proliferation
Pathways			Molecules associated with elastic fibres Molecules associated with elastic fibres
Drugs		Insulin Human Insulin Pork
Diseases			Synpolydactyly, 3/3'4, associated with metacarpal and metatarsal synostoses
GWAS			Blood protein levels ( 30072576) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Paneth cell defects in Crohn's disease ( 28352666) QT interval ( 29213071) Red blood cell count ( 27863252) Temperament (bipolar disorder) ( 22365631)
Interacting Genes		14 interacting genes: ADSL CCN2 CDKN1A DLL1 FBLN1 FN1 GJA1 IGF1 IGF2 INS ITGAV NOTCH1 POLR2L S100A4	39 interacting genes: ACAN ADAMTSL2 ADAMTSL4 APOA1 APP ATN1 BHLHE40 CACNA1A CCN2 CCN3 DDIAS ECM1 EDC4 ELN FGB FN1 GFI1B HBEGF HSPG2 ITGB1 LTBP4 MCPH1 MFAP5 MOB4 NEDD1 NID1 NLGN3 NOTCH3 PLSCR1 SKIL SMAD3 SMAD4 TAF9 TANK TCF7L2 TDGF1 TLE5 VCAN YWHAQ
Entrez ID		4856	2192
HPRD ID		01291	00629
Ensembl ID		ENSG00000136999	ENSG00000077942
Uniprot IDs		A0A024R9J4 P48745	P23142 Q8NBH6
PDB IDs
Enriched GO Terms of Interacting Partners?
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