FBLN1 and ECM1

Number of citations of the paper that reports this interaction (PubMedID 15990087)
7

Data Source:
HPRD (two hybrid, in vitro)

		FBLN1	ECM1
Description		fibulin 1	extracellular matrix protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Space Extracellular Matrix Collagen-containing Extracellular Matrix Extracellular Exosome Elastic Fiber	Extracellular Region Extracellular Matrix Platelet Dense Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Fibronectin Binding Extracellular Matrix Structural Constituent Calcium Ion Binding Protein C-terminus Binding Peptidase Activator Activity Identical Protein Binding Protein-containing Complex Binding Fibrinogen Binding	Protease Binding Interleukin-2 Receptor Binding Extracellular Matrix Structural Constituent Protein Binding Protein C-terminus Binding Enzyme Binding Laminin Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation Negative Regulation Of Cell Adhesion Integrin-mediated Signaling Pathway Embryo Implantation Positive Regulation Of Peptidase Activity Viral Process Extracellular Matrix Organization Negative Regulation Of ERK1 And ERK2 Cascade Blood Coagulation, Fibrin Clot Formation Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Cell Motility Negative Regulation Of Stem Cell Proliferation	Ossification Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Negative Regulation Of Cytokine-mediated Signaling Pathway Chondrocyte Development Platelet Degranulation Regulation Of Type 2 Immune Response Endochondral Bone Growth Regulation Of Transcription By RNA Polymerase II Inflammatory Response Signal Transduction Negative Regulation Of Peptidase Activity Negative Regulation Of Bone Mineralization Biomineral Tissue Development Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Angiogenesis Regulation Of T Cell Migration
Pathways		Molecules associated with elastic fibres Molecules associated with elastic fibres	Platelet degranulation
Drugs
Diseases		Synpolydactyly, 3/3'4, associated with metacarpal and metatarsal synostoses	Lipoid proteinosis; Urbach-Wiethe disease
GWAS		Blood protein levels ( 30072576) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Paneth cell defects in Crohn's disease ( 28352666) QT interval ( 29213071) Red blood cell count ( 27863252) Temperament (bipolar disorder) ( 22365631)	Blood protein levels ( 30072576 28240269) Migraine ( 27322543) Schizophrenia ( 28991256 30285260)
Interacting Genes		39 interacting genes: ACAN ADAMTSL2 ADAMTSL4 APOA1 APP ATN1 BHLHE40 CACNA1A CCN2 CCN3 DDIAS ECM1 EDC4 ELN FGB FN1 GFI1B HBEGF HSPG2 ITGB1 LTBP4 MCPH1 MFAP5 MOB4 NEDD1 NID1 NLGN3 NOTCH3 PLSCR1 SKIL SMAD3 SMAD4 TAF9 TANK TCF7L2 TDGF1 TLE5 VCAN YWHAQ	9 interacting genes: ATN1 BNIP3L CPTP DDIAS FBLN1 HSPG2 IRAK3 RERE SRPK1
Entrez ID		2192	1893
HPRD ID		00629	03727
Ensembl ID		ENSG00000077942	ENSG00000143369
Uniprot IDs		P23142 Q8NBH6	A0A140VJI7 Q16610
PDB IDs
Enriched GO Terms of Interacting Partners?
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