FBLN1 and ACAN

Number of citations of the paper that reports this interaction (PubMedID 10400671)
48

Data Source:
HPRD (in vitro)

		FBLN1	ACAN
Description		fibulin 1	aggrecan
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Space Extracellular Matrix Collagen-containing Extracellular Matrix Extracellular Exosome Elastic Fiber	Extracellular Region Basement Membrane Golgi Lumen Extracellular Matrix Lysosomal Lumen Collagen-containing Extracellular Matrix Perisynaptic Extracellular Matrix Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	Fibronectin Binding Extracellular Matrix Structural Constituent Calcium Ion Binding Protein C-terminus Binding Peptidase Activator Activity Identical Protein Binding Protein-containing Complex Binding Fibrinogen Binding	Extracellular Matrix Structural Constituent Protein Binding Hyaluronic Acid Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Carbohydrate Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation Negative Regulation Of Cell Adhesion Integrin-mediated Signaling Pathway Embryo Implantation Positive Regulation Of Peptidase Activity Viral Process Extracellular Matrix Organization Negative Regulation Of ERK1 And ERK2 Cascade Blood Coagulation, Fibrin Clot Formation Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Cell Motility Negative Regulation Of Stem Cell Proliferation	Skeletal System Development Cartilage Condensation Chondrocyte Development Proteolysis Cell Adhesion Central Nervous System Development Heart Development Keratan Sulfate Biosynthetic Process Proteoglycan Biosynthetic Process Extracellular Matrix Organization Collagen Fibril Organization Keratan Sulfate Catabolic Process
Pathways		Molecules associated with elastic fibres Molecules associated with elastic fibres	Degradation of the extracellular matrix Degradation of the extracellular matrix Keratan sulfate biosynthesis Keratan sulfate degradation ECM proteoglycans Defective CHST6 causes MCDC1 Defective ST3GAL3 causes MCT12 and EIEE15 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
Drugs			GM6001
Diseases		Synpolydactyly, 3/3'4, associated with metacarpal and metatarsal synostoses	Spondyloepiphyseal dysplasia, Kimberley type Familial osteochondritis dissecans; Osteochondritis dissecans, short stature, and early-onset osteoarthritis
GWAS		Blood protein levels ( 30072576) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Paneth cell defects in Crohn's disease ( 28352666) QT interval ( 29213071) Red blood cell count ( 27863252) Temperament (bipolar disorder) ( 22365631)	Age-related hearing impairment ( 27764096) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Dupuytren's disease ( 28886342) Height ( 21998595 28552196 20881960 25282103 25133637 25429064 23563607 31562340 28270201 18391952) Hip circumference adjusted for BMI ( 25673412) Infant length ( 25281659) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500)
Interacting Genes		39 interacting genes: ACAN ADAMTSL2 ADAMTSL4 APOA1 APP ATN1 BHLHE40 CACNA1A CCN2 CCN3 DDIAS ECM1 EDC4 ELN FGB FN1 GFI1B HBEGF HSPG2 ITGB1 LTBP4 MCPH1 MFAP5 MOB4 NEDD1 NID1 NLGN3 NOTCH3 PLSCR1 SKIL SMAD3 SMAD4 TAF9 TANK TCF7L2 TDGF1 TLE5 VCAN YWHAQ	17 interacting genes: ADAMTS1 ADAMTS4 ADAMTS5 CTSB FBLN1 FBLN2 HAPLN1 LUM MMP1 MMP14 MMP19 MMP2 MMP20 MMP3 MMP8 TNFAIP6 TNR
Entrez ID		2192	176
HPRD ID		00629	01123
Ensembl ID		ENSG00000077942	ENSG00000157766
Uniprot IDs		P23142 Q8NBH6	P16112
PDB IDs			4MD4
Enriched GO Terms of Interacting Partners?
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