CCN3 and S100A4

Number of citations of the paper that reports this interaction (PubMedID 12147716)
23

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		CCN3	S100A4
Description		cellular communication network factor 3	S100 calcium binding protein A4
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Gap Junction Axon Dendrite Extracellular Matrix Neuronal Cell Body Intracellular Membrane-bounded Organelle Collagen-containing Extracellular Matrix	Extracellular Region Extracellular Space Nucleus Neuron Projection Perinuclear Region Of Cytoplasm Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Notch Binding Integrin Binding Protein Binding Insulin-like Growth Factor Binding Growth Factor Activity Heparin Binding	RNA Binding Actin Binding Calcium Ion Binding Protein Binding Identical Protein Binding Transition Metal Ion Binding Calcium-dependent Protein Binding RAGE Receptor Binding
	Biological Process	Angiogenesis Chondrocyte Differentiation Cell Adhesion Signal Transduction Regulation Of Gene Expression Fibroblast Migration Negative Regulation Of Myotube Differentiation Smooth Muscle Cell Migration Negative Regulation Of Cell Growth Cell Adhesion Mediated By Integrin Endothelial Cell Chemotaxis Type B Pancreatic Cell Proliferation Positive Regulation Of Notch Signaling Pathway Negative Regulation Of Insulin Secretion Smooth Muscle Cell Proliferation Negative Regulation Of Inflammatory Response Cell Chemotaxis Negative Regulation Of SMAD Protein Signal Transduction Negative Regulation Of Cell Death Hematopoietic Stem Cell Homeostasis Endothelial Cell-cell Adhesion Negative Regulation Of Monocyte Chemotaxis Negative Regulation Of NIK/NF-kappaB Signaling Negative Regulation Of Chondrocyte Proliferation Negative Regulation Of Sensory Perception Of Pain Bone Regeneration	Epithelial To Mesenchymal Transition Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Pathways
Drugs		Insulin Human Insulin Pork	Trifluoperazine Copper
Diseases
GWAS			Blood protein levels ( 29875488) Pulse pressure ( 30578418)
Interacting Genes		14 interacting genes: ADSL CCN2 CDKN1A DLL1 FBLN1 FN1 GJA1 IGF1 IGF2 INS ITGAV NOTCH1 POLR2L S100A4	27 interacting genes: ACTA1 ANXA2 BAG6 CCN3 CEP20 EGFR FCGR3A HSPB1 MDM2 METAP2 MYH10 MYH2 MYH4 MYH9 PPFIBP1 RHOU S100A1 S100P SEPTIN2 SEPTIN6 SEPTIN7 SMAD3 SRPK2 TP53 TPM2 TPM3 UNC119
Entrez ID		4856	6275
HPRD ID		01291	15914
Ensembl ID		ENSG00000136999	ENSG00000196154
Uniprot IDs		A0A024R9J4 P48745	P26447
PDB IDs			1M31 2LNK 2MRD 2Q91 3C1V 3CGA 3KO0 3M0W 3ZWH 4CFQ 4CFR 4ETO 4HSZ 5LPU
Enriched GO Terms of Interacting Partners?
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