HSPA4 and NAA10

Number of citations of the paper that reports this interaction (PubMedID 27708256)
25

Data Source:
BioGRID (enzymatic study)

		HSPA4	NAA10
Description		heat shock protein family A (Hsp70) member 4	N-alpha-acetyltransferase 10, NatA catalytic subunit
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Extracellular Exosome	Intracellular Nucleus Nucleolus Cytoplasm Cytosol Membrane NatA Complex
	Molecular Function	Protein Binding ATP Binding	Peptide Alpha-N-acetyltransferase Activity Protein Binding N-acetyltransferase Activity Acetyltransferase Activity Ribosome Binding Peptide-serine-N-acetyltransferase Activity Peptide-glutamate-N-acetyltransferase Activity
	Biological Process	Response To Unfolded Protein Protein Import Into Mitochondrial Outer Membrane Chaperone-mediated Protein Complex Assembly	DNA Packaging Protein Acetylation N-terminal Protein Amino Acid Acetylation Internal Protein Amino Acid Acetylation N-terminal Peptidyl-serine Acetylation N-terminal Peptidyl-glutamic Acid Acetylation Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric
Pathways		Regulation of HSF1-mediated heat shock response
Drugs		Phenethyl Isothiocyanate
Diseases
GWAS		Breast cancer ( 29059683) Chronic obstructive pulmonary disease ( 30804561) Diastolic blood pressure ( 30224653) Eyebrow thickness ( 26926045) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heel bone mineral density ( 30598549) Metabolite levels ( 23823483) Reticulocyte fraction of red cells ( 27863252) Triglyceride levels ( 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)	Systemic lupus erythematosus ( 26502338)
Interacting Genes		65 interacting genes: ABCC2 AGTRAP APPBP2 BAG1 BAG2 BAG5 BRMS1 CALM1 CD40 CDC73 CDKN2A CSNK1A1 CSNK2A1 DDIT4 DNAJB1 DNAJB2 DUSP1 EGFR ESR1 FANCC FES FKBP4 GATA1 GRPEL2 GSK3B GZMA HAP1 HDAC3 HNRNPD HSPB1 HSPBP1 IKBKG KPNA2 KRT18 MUC1 NAA10 NFKB1 NR3C2 OLR1 PA2G4 PHLDA1 PPP1CA PRKACA PRKCB PRKCD PRKCG PRSS23 PSMD10 RAF1 RAP1A REL RELA SGTA SIRPA SMAD3 ST13 STUB1 SUGT1 TERT TOMM40 TRAF6 TRIM32 TTC1 UBE2L3 UBE3A	29 interacting genes: BCOR CALCOCO2 CDC25A CEP44 CREB3 EHMT2 FIP1L1 HIF1A HIF1AN HSPA4 KIFAP3 KRTAP10-3 KRTAP10-5 KRTAP10-7 MEOX2 NAA15 NAA16 NAA50 NAT1 NAT2 PDE4DIP PGK1 PSME2 RAB3IP RBCK1 RPL26 SSX2IP UBC ZBTB14
Entrez ID		3308	8260
HPRD ID		09025	02056
Ensembl ID		ENSG00000170606	ENSG00000102030
Uniprot IDs		P34932	B7Z9N2 P41227
PDB IDs			6C95 6C9M
Enriched GO Terms of Interacting Partners?
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