HSPA4 and FKBP4

Number of citations of the paper that reports this interaction (PubMedID 10642522)
1

Data Source:
BioGRID (pull down)

		HSPA4	FKBP4
Description		heat shock protein family A (Hsp70) member 4	FKBP prolyl isomerase 4
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Extracellular Exosome	Nucleoplasm Cytoplasm Mitochondrion Cytosol Microtubule Protein-containing Complex Neuronal Cell Body Axonal Growth Cone Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Protein Binding ATP Binding	RNA Binding Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding ATP Binding GTP Binding FK506 Binding Protein Binding, Bridging Heat Shock Protein Binding Copper-dependent Protein Binding Glucocorticoid Receptor Binding Tau Protein Binding Phosphoprotein Binding
	Biological Process	Response To Unfolded Protein Protein Import Into Mitochondrial Outer Membrane Chaperone-mediated Protein Complex Assembly	Protein Peptidyl-prolyl Isomerization Protein Folding Steroid Hormone Receptor Complex Assembly Copper Ion Transport Embryo Implantation Negative Regulation Of Neuron Projection Development Androgen Receptor Signaling Pathway Prostate Gland Development Negative Regulation Of Microtubule Polymerization Or Depolymerization Negative Regulation Of Microtubule Polymerization Protein-containing Complex Localization Male Sex Differentiation Chaperone-mediated Protein Folding Regulation Of Cellular Response To Heat
Pathways		Regulation of HSF1-mediated heat shock response	HSP90 chaperone cycle for steroid hormone receptors (SHR) Attenuation phase ESR-mediated signaling Estrogen-dependent gene expression
Drugs		Phenethyl Isothiocyanate
Diseases
GWAS		Breast cancer ( 29059683) Chronic obstructive pulmonary disease ( 30804561) Diastolic blood pressure ( 30224653) Eyebrow thickness ( 26926045) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heel bone mineral density ( 30598549) Metabolite levels ( 23823483) Reticulocyte fraction of red cells ( 27863252) Triglyceride levels ( 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)	FEV1 ( 30804560) Lung function (FVC) ( 30804560) Peak expiratory flow ( 30804560) Quantitative traits ( 19197348)
Interacting Genes		65 interacting genes: ABCC2 AGTRAP APPBP2 BAG1 BAG2 BAG5 BRMS1 CALM1 CD40 CDC73 CDKN2A CSNK1A1 CSNK2A1 DDIT4 DNAJB1 DNAJB2 DUSP1 EGFR ESR1 FANCC FES FKBP4 GATA1 GRPEL2 GSK3B GZMA HAP1 HDAC3 HNRNPD HSPB1 HSPBP1 IKBKG KPNA2 KRT18 MUC1 NAA10 NFKB1 NR3C2 OLR1 PA2G4 PHLDA1 PPP1CA PRKACA PRKCB PRKCD PRKCG PRSS23 PSMD10 RAF1 RAP1A REL RELA SGTA SIRPA SMAD3 ST13 STUB1 SUGT1 TERT TOMM40 TRAF6 TRIM32 TTC1 UBE2L3 UBE3A	26 interacting genes: ACVR1 AHSA1 ATOX1 CALM1 CSNK2A1 EGFR ESR1 FES FKBP1A GLMN HSF1 HSP90AA1 HSPA4 IRF4 NR3C1 NR3C2 PHYH PTPN2 S100A1 S100A2 S100A6 SH3BP4 SMURF2 SNCA SQSTM1 STIP1
Entrez ID		3308	2288
HPRD ID		09025	11794
Ensembl ID		ENSG00000170606	ENSG00000004478
Uniprot IDs		P34932	Q02790
PDB IDs			1N1A 1P5Q 1Q1C 1QZ2 4DRJ 4LAV 4LAW 4LAX 4LAY 4TW8
Enriched GO Terms of Interacting Partners?
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