HSPA4 and DNAJB2

Number of citations of the paper that reports this interaction (PubMedID 22219199)
12

Data Source:
BioGRID (imaging technique, pull down)

		HSPA4	DNAJB2
Description		heat shock protein family A (Hsp70) member 4	DnaJ heat shock protein family (Hsp40) member B2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Extracellular Exosome	Proteasome Complex Cell Nucleus Cytosol Intrinsic Component Of Endoplasmic Reticulum Membrane Nuclear Membrane
	Molecular Function	Protein Binding ATP Binding	ATPase Activator Activity Protein Binding Hsp70 Protein Binding Ubiquitin Binding Unfolded Protein Binding Chaperone Binding Ubiquitin-dependent Protein Binding
	Biological Process	Response To Unfolded Protein Protein Import Into Mitochondrial Outer Membrane Chaperone-mediated Protein Complex Assembly	Response To Unfolded Protein Negative Regulation Of Cell Proliferation Negative Regulation Of Cell Growth Ubiquitin-dependent ERAD Pathway Regulation Of Protein Ubiquitination Negative Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of ATPase Activity Protein Refolding Chaperone-mediated Protein Folding Neuron Cellular Homeostasis Negative Regulation Of Inclusion Body Assembly Regulation Of Chaperone-mediated Protein Folding
Pathways		Regulation of HSF1-mediated heat shock response
Drugs		Phenethyl Isothiocyanate
Diseases
GWAS		Breast cancer ( 29059683) Chronic obstructive pulmonary disease ( 30804561) Diastolic blood pressure ( 30224653) Eyebrow thickness ( 26926045) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heel bone mineral density ( 30598549) Metabolite levels ( 23823483) Reticulocyte fraction of red cells ( 27863252) Triglyceride levels ( 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
Interacting Genes		65 interacting genes: ABCC2 AGTRAP APPBP2 BAG1 BAG2 BAG5 BRMS1 CALM1 CD40 CDC73 CDKN2A CSNK1A1 CSNK2A1 DDIT4 DNAJB1 DNAJB2 DUSP1 EGFR ESR1 FANCC FES FKBP4 GATA1 GRPEL2 GSK3B GZMA HAP1 HDAC3 HNRNPD HSPB1 HSPBP1 IKBKG KPNA2 KRT18 MUC1 NAA10 NFKB1 NR3C2 OLR1 PA2G4 PHLDA1 PPP1CA PRKACA PRKCB PRKCD PRKCG PRSS23 PSMD10 RAF1 RAP1A REL RELA SGTA SIRPA SMAD3 ST13 STUB1 SUGT1 TERT TOMM40 TRAF6 TRIM32 TTC1 UBE2L3 UBE3A	9 interacting genes: CSNK2A1 FBXO25 HSPA4 MAP3K1 RPS27A SMAD4 UBA52 UBC UBQLN1
Entrez ID		3308	3300
HPRD ID		09025	07249
Ensembl ID		ENSG00000170606	ENSG00000135924
Uniprot IDs		P34932	P25686
PDB IDs			2LGW
Enriched GO Terms of Interacting Partners?
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