TRIM59 and ECSIT

Number of citations of the paper that reports this interaction (PubMedID 22588174)
14

Data Source:
BioGRID (two hybrid)

		TRIM59	ECSIT
Description		tripartite motif containing 59	ECSIT signaling integrator
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane Intraciliary Transport Particle B	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Inner Membrane Cytosol
	Molecular Function	Protein Binding Zinc Ion Binding	Protein Binding
	Biological Process	Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response	Mitochondrial Respiratory Chain Complex I Assembly Innate Immune Response Regulation Of Oxidoreductase Activity Regulation Of Protein Complex Stability
Pathways			MyD88:MAL(TIRAP) cascade initiated on plasma membrane Complex I biogenesis TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 cascade initiated on plasma membrane
Drugs
Diseases
GWAS		Alcohol use disorder (total score) ( 30336701) Bipolar disorder ( 31043756) Intrinsic epigenetic age acceleration ( 29374233) Pulse pressure ( 30578418) Systolic blood pressure ( 30578418)	Presence of antiphospholipid antibodies ( 27098658)
Interacting Genes		9 interacting genes: ECSIT ESR1 ESR2 NRM OTOL1 PPM1L RHOU VTI1B ZDHHC22	50 interacting genes: A2M AP1M2 APOE APP BLMH CDC37 CEP55 CNN1 CORO2B CYP2C18 CYP2C8 CYP2C9 DNAJB1 DYNC1H1 ELAVL3 EXOC6 EXOSC1 FARSA FBXL12 FBXW4 GCDH IFIT3 IFIT5 IMMT LONP1 LOXL4 MARCHF2 MAST1 MRPL4 NDUFA13 NFKB1 PAXIP1 PI4K2A PRDX2 PSEN1 RAB3A RAD23A RELA RHEB RNF32 SELPLG SETDB1 SHFL SMAD1 SMAD4 SMURF1 STAMBPL1 STRN4 TRAF6 TRIM59
Entrez ID		286827	51295
HPRD ID		15568	12225
Ensembl ID		ENSG00000213186	ENSG00000130159
Uniprot IDs		Q8IWR1	Q9BQ95
PDB IDs
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?