DYRK1A and SF3B1

Number of citations of the paper that reports this interaction (PubMedID 16512921)
28

Data Source:
HPRD (in vitro, in vivo)

		DYRK1A	SF3B1
Description		dual specificity tyrosine phosphorylation regulated kinase 1A	splicing factor 3b subunit 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytoskeleton Nuclear Speck Axon Dendrite Ribonucleoprotein Complex	Nucleus Nucleoplasm Spliceosomal Complex U2 SnRNP U12-type Spliceosomal Complex Nuclear Speck U11/U12 SnRNP U2-type Prespliceosome U2-type Precatalytic Spliceosome Catalytic Step 2 Spliceosome
	Molecular Function	Transcription Coactivator Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Identical Protein Binding Protein Self-association Tau Protein Binding Tau-protein Kinase Activity	RNA Binding MRNA Binding Protein Binding Splicing Factor Binding
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome Protein Phosphorylation Nervous System Development Circadian Rhythm Viral Process Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Peptidyl-tyrosine Phosphorylation Negative Regulation Of Microtubule Polymerization Positive Regulation Of RNA Splicing Amyloid-beta Formation Peptidyl-serine Autophosphorylation Peptidyl-tyrosine Autophosphorylation Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation Negative Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Protein Deacetylation	Spliceosomal Complex Assembly RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome RNA Splicing Positive Regulation Of Gene Expression, Epigenetic
Pathways		G0 and Early G1	B-WICH complex positively regulates rRNA expression mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway
Drugs		N-(5-{[(2S)-4-amino-2-(3-chlorophenyl)butanoyl]amino}-1H-indazol-3-yl)benzamide
Diseases
GWAS		HIV-1 replication ( 21364930) Metabolic syndrome ( 20694148) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Stroke ( 30383316)	Autism spectrum disorder or schizophrenia ( 28540026) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Major depressive disorder ( 27479909) Morning person ( 30696823) Schizophrenia ( 25056061 29483656 30285260)
Interacting Genes		31 interacting genes: - AMPH APP CCNL2 CLASRP CREB1 EIF2B5 FOXO1 GLI1 H2BC3 H3C1 H4C1 ID2 LATS2 LIN52 MAPT PEA15 PHYHIP PRKN RB1 RBL1 RNF169 SF3B1 SNCA SRSF1 SRSF4 SRSF5 TROAP YWHAB YWHAE YWHAG	24 interacting genes: APBB1 C11orf58 CALM1 CLK1 CSNK2A1 DYRK1A ERG IL7R MELK MYC NUDT21 PLRG1 PPP1R8 PRPF40A SF1 SF3B3 SF3B6 SMAD1 SMAD5 SMAD9 SNIP1 TCERG1 TOP1 WBP4
Entrez ID		1859	23451
HPRD ID		09018	09281
Ensembl ID		ENSG00000157540	ENSG00000115524
Uniprot IDs		A0A2R8Y6I6 Q13627	B4DGZ4 O75533
PDB IDs		2VX3 2WO6 3ANQ 3ANR 4AZE 4MQ1 4MQ2 4NCT 4YLJ 4YLK 4YLL 4YU2 5A3X 5A4E 5A4L 5A4Q 5A4T 5A54 5AIK 6A1F 6A1G 6EIF 6EIJ 6EIL 6EIP 6EIQ 6EIR 6EIS 6EIV 6EJ4 6S11 6S14 6S17 6S1B 6S1H 6S1I 6S1J	2F9D 2F9J 2FHO 2PEH 3LQV 4OZ1 5IFE 5O9Z 5Z56 5Z57 5Z58 5ZYA 6AH0 6EN4 6FF4 6FF7 6N3E 6QX9
Enriched GO Terms of Interacting Partners?
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