SF3B1 and WBP4

Number of citations of the paper that reports this interaction (PubMedID 16055720)
81

Data Source:
BioGRID (pull down)

		SF3B1	WBP4
Description		splicing factor 3b subunit 1	WW domain binding protein 4
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U2 SnRNP U12-type Spliceosomal Complex Nuclear Speck U11/U12 SnRNP U2-type Prespliceosome U2-type Precatalytic Spliceosome Catalytic Step 2 Spliceosome	Nucleus Nucleoplasm Nuclear Speck U2-type Precatalytic Spliceosome Precatalytic Spliceosome
	Molecular Function	RNA Binding MRNA Binding Protein Binding Splicing Factor Binding	Nucleic Acid Binding RNA Binding Protein Binding Zinc Ion Binding Proline-rich Region Binding
	Biological Process	Spliceosomal Complex Assembly RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome RNA Splicing Positive Regulation Of Gene Expression, Epigenetic	MRNA Splicing, Via Spliceosome RNA Splicing MRNA Cis Splicing, Via Spliceosome
Pathways		B-WICH complex positively regulates rRNA expression mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Major depressive disorder ( 27479909) Morning person ( 30696823) Schizophrenia ( 25056061 29483656 30285260)	Crohn's disease ( 23266558) CSF tryptophan concentration in tuberculous meningitis ( 29395996) Intraocular pressure ( 29617998) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269)
Interacting Genes		24 interacting genes: APBB1 C11orf58 CALM1 CLK1 CSNK2A1 DYRK1A ERG IL7R MELK MYC NUDT21 PLRG1 PPP1R8 PRPF40A SF1 SF3B3 SF3B6 SMAD1 SMAD5 SMAD9 SNIP1 TCERG1 TOP1 WBP4	44 interacting genes: BUB3 CAPRIN1 CHERP CHTF8 CPSF6 CPSF7 DDX23 DDX3X DHX15 DIAPH1 DNM2 EFTUD2 EWSR1 FUS HLTF HNRNPK HNRNPU HTATSF1 KHDRBS1 NONO PABPC1 PRPF3 PRPF4 PRPF40A PSPC1 SART1 SCAF4 SF1 SF3A1 SF3A2 SF3A3 SF3B1 SF3B3 SF3B4 SFPQ SNRNP70 SNRPA SNRPB TCERG1 WAS WBP11 WIPF1 XRCC6 ZNF207
Entrez ID		23451	11193
HPRD ID		09281	16086
Ensembl ID		ENSG00000115524	ENSG00000120688
Uniprot IDs		B4DGZ4 O75533	O75554
PDB IDs		2F9D 2F9J 2FHO 2PEH 3LQV 4OZ1 5IFE 5O9Z 5Z56 5Z57 5Z58 5ZYA 6AH0 6EN4 6FF4 6FF7 6N3E 6QX9	2DK1 2JXW 5O9Z 6AHD
Enriched GO Terms of Interacting Partners?
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