DYRK1A and EIF2B5

Number of citations of the paper that reports this interaction (PubMedID 11311121)
87

Data Source:
BioGRID (enzymatic study)

		DYRK1A	EIF2B5
Description		dual specificity tyrosine phosphorylation regulated kinase 1A	eukaryotic translation initiation factor 2B subunit epsilon
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytoskeleton Nuclear Speck Axon Dendrite Ribonucleoprotein Complex	Nucleus Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2B Complex
	Molecular Function	Transcription Coactivator Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Identical Protein Binding Protein Self-association Tau Protein Binding Tau-protein Kinase Activity	Translation Initiation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Translation Initiation Factor Binding
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome Protein Phosphorylation Nervous System Development Circadian Rhythm Viral Process Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Peptidyl-tyrosine Phosphorylation Negative Regulation Of Microtubule Polymerization Positive Regulation Of RNA Splicing Amyloid-beta Formation Peptidyl-serine Autophosphorylation Peptidyl-tyrosine Autophosphorylation Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation Negative Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Protein Deacetylation	Ovarian Follicle Development Translational Initiation Aging Response To Heat Response To Glucose Response To Lithium Ion Astrocyte Development Oligodendrocyte Development Hippocampus Development Response To Endoplasmic Reticulum Stress Myelination Positive Regulation Of Apoptotic Process Response To Peptide Hormone Positive Regulation Of Translational Initiation Astrocyte Differentiation T Cell Receptor Signaling Pathway
Pathways		G0 and Early G1	Recycling of eIF2:GDP
Drugs		N-(5-{[(2S)-4-amino-2-(3-chlorophenyl)butanoyl]amino}-1H-indazol-3-yl)benzamide
Diseases			Leukoencephalopathy with vanishing white matter; Vanishing white matter disease; Childhood ataxia with diffuse central nervous system hypomyelination (CACH); Cree leukoencephalopathy (CLE)
GWAS		HIV-1 replication ( 21364930) Metabolic syndrome ( 20694148) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Stroke ( 30383316)	General cognitive ability ( 29844566) Immature fraction of reticulocytes ( 27863252) Major depressive disorder ( 22472876) Platelet count ( 27863252) Plateletcrit ( 27863252)
Interacting Genes		31 interacting genes: - AMPH APP CCNL2 CLASRP CREB1 EIF2B5 FOXO1 GLI1 H2BC3 H3C1 H4C1 ID2 LATS2 LIN52 MAPT PEA15 PHYHIP PRKN RB1 RBL1 RNF169 SF3B1 SNCA SRSF1 SRSF4 SRSF5 TROAP YWHAB YWHAE YWHAG	11 interacting genes: APP CHMP2A CSNK1A1 CSNK2A1 CSNK2A2 DYRK1A DYRK2 EIF2B2 EIF2S2 GSK3A GSK3B
Entrez ID		1859	8893
HPRD ID		09018	04898
Ensembl ID		ENSG00000157540	ENSG00000145191
Uniprot IDs		A0A2R8Y6I6 Q13627	Q13144
PDB IDs		2VX3 2WO6 3ANQ 3ANR 4AZE 4MQ1 4MQ2 4NCT 4YLJ 4YLK 4YLL 4YU2 5A3X 5A4E 5A4L 5A4Q 5A4T 5A54 5AIK 6A1F 6A1G 6EIF 6EIJ 6EIL 6EIP 6EIQ 6EIR 6EIS 6EIV 6EJ4 6S11 6S14 6S17 6S1B 6S1H 6S1I 6S1J	3JUI 6CAJ 6EZO 6K71 6K72 6O81 6O85 6O9Z
Enriched GO Terms of Interacting Partners?
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