SF3B1 and C11orf58

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		SF3B1	C11orf58
Description		splicing factor 3b subunit 1	chromosome 11 open reading frame 58
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U2 SnRNP U12-type Spliceosomal Complex Nuclear Speck U11/U12 SnRNP U2-type Prespliceosome U2-type Precatalytic Spliceosome Catalytic Step 2 Spliceosome	Cellular_component
	Molecular Function	RNA Binding MRNA Binding Protein Binding Splicing Factor Binding	Molecular_function
	Biological Process	Spliceosomal Complex Assembly RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome RNA Splicing Positive Regulation Of Gene Expression, Epigenetic	Biological_process
Pathways		B-WICH complex positively regulates rRNA expression mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Major depressive disorder ( 27479909) Morning person ( 30696823) Schizophrenia ( 25056061 29483656 30285260)	Chronotype ( 30696823) Femoral neck bone mineral density ( 29499414) Heel bone mineral density ( 30598549 28869591) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Lumbar spine bone mineral density ( 29499414) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Reticulocyte count ( 27863252)
Interacting Genes		24 interacting genes: APBB1 C11orf58 CALM1 CLK1 CSNK2A1 DYRK1A ERG IL7R MELK MYC NUDT21 PLRG1 PPP1R8 PRPF40A SF1 SF3B3 SF3B6 SMAD1 SMAD5 SMAD9 SNIP1 TCERG1 TOP1 WBP4	16 interacting genes: A2M CEP126 EEF1G FBN3 MBTPS1 POLR2C PTN RNF19A RPLP1 SEMA5B SF3B1 SHC1 SLC44A1 SNCAIP TRA2A ZBTB48
Entrez ID		23451	10944
HPRD ID		09281	18069
Ensembl ID		ENSG00000115524	ENSG00000110696
Uniprot IDs		B4DGZ4 O75533	O00193
PDB IDs		2F9D 2F9J 2FHO 2PEH 3LQV 4OZ1 5IFE 5O9Z 5Z56 5Z57 5Z58 5ZYA 6AH0 6EN4 6FF4 6FF7 6N3E 6QX9
Enriched GO Terms of Interacting Partners?
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