ADORA2B and NTN1

Number of citations of the paper that reports this interaction (PubMedID 11048721)
55

Data Source:
HPRD (in vivo, in vitro)

		ADORA2B	NTN1
Description		adenosine A2b receptor	netrin 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Schaffer Collateral - CA1 Synapse Glutamatergic Synapse	Extracellular Region Basement Membrane Cytoplasm
	Molecular Function	G Protein-coupled Adenosine Receptor Activity Protein Binding	Protein Binding
	Biological Process	Activation Of MAPK Activity Adenosine Receptor Signaling Pathway Positive Regulation Of Chronic Inflammatory Response To Non-antigenic Stimulus Cellular Defense Response G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity JNK Cascade Excretion Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of CGMP-mediated Signaling Positive Regulation Of Guanylate Cyclase Activity Cellular Response To Extracellular Stimulus Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Mast Cell Degranulation Cellular Protein Metabolic Process Relaxation Of Vascular Smooth Muscle Regulation Of Synaptic Vesicle Exocytosis	Neuron Migration Apoptotic Process Substrate-dependent Cell Migration, Cell Extension Nuclear Migration Ras Protein Signal Transduction Motor Neuron Axon Guidance Positive Regulation Of Cell Proliferation Animal Organ Morphogenesis Tissue Development Dendrite Development Regulation Of Cell Migration Negative Regulation Of Axon Extension Cdc42 Protein Signal Transduction Anterior/posterior Axon Guidance Inner Ear Morphogenesis Positive Regulation Of Axon Extension Regulation Of Synapse Assembly Mammary Gland Duct Morphogenesis Chemorepulsion Of Axon Cell-cell Adhesion Negative Regulation Of Netrin-activated Signaling Pathway Positive Regulation Of Cell Motility
Pathways		Adenosine P1 receptors G alpha (s) signalling events Surfactant metabolism ADORA2B mediated anti-inflammatory cytokines production	Netrin-1 signaling Netrin-1 signaling DSCAM interactions DCC mediated attractive signaling DCC mediated attractive signaling Netrin mediated repulsion signals Role of second messengers in netrin-1 signaling Regulation of commissural axon pathfinding by SLIT and ROBO
Drugs		Theophylline Adenosine Enprofylline Defibrotide
Diseases
GWAS		Immune reponse to smallpox (secreted IL-12p40) ( 22610502)	Bisphosphonate-associated atypical femoral fracture ( 31006051) Blood protein levels ( 30072576 29875488) Breast cancer (prognosis) ( 23319801) Cleft lip with or without cleft palate ( 28054174) Cortex volume ( 31530798) Feeling hurt ( 29500382) Heel bone mineral density ( 30598549 28869591) Nonsyndromic cleft lip with cleft palate ( 28232668) Nonsyndromic cleft lip with or without cleft palate ( 25775280) Orofacial clefts ( 28054174) Percentage gas trapping ( 26030696) Rostral middle frontal gyrus volume ( 31530798) Total grey matter volume ( 31530798)
Interacting Genes		7 interacting genes: ADA DCC EZR NTN1 SLC9A3R2 TPD52L2 ZNF267	5 interacting genes: ADORA2B DCC NEO1 UNC5A UNC5C
Entrez ID		136	9423
HPRD ID		15971	03368
Ensembl ID		ENSG00000170425	ENSG00000065320
Uniprot IDs		P29275	O95631
PDB IDs			4URT 6FKQ
Enriched GO Terms of Interacting Partners?
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