ADORA2B and DCC

Number of citations of the paper that reports this interaction (PubMedID 11048721)
55

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		ADORA2B	DCC
Description		adenosine A2b receptor	DCC netrin 1 receptor
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Schaffer Collateral - CA1 Synapse Glutamatergic Synapse	Cytosol Plasma Membrane Axon Schaffer Collateral - CA1 Synapse Integral Component Of Postsynaptic Density Membrane
	Molecular Function	G Protein-coupled Adenosine Receptor Activity Protein Binding	Transmembrane Signaling Receptor Activity Netrin Receptor Activity Protein Binding
	Biological Process	Activation Of MAPK Activity Adenosine Receptor Signaling Pathway Positive Regulation Of Chronic Inflammatory Response To Non-antigenic Stimulus Cellular Defense Response G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity JNK Cascade Excretion Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of CGMP-mediated Signaling Positive Regulation Of Guanylate Cyclase Activity Cellular Response To Extracellular Stimulus Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Mast Cell Degranulation Cellular Protein Metabolic Process Relaxation Of Vascular Smooth Muscle Regulation Of Synaptic Vesicle Exocytosis	Neuron Migration Apoptotic Process Axonogenesis Axon Guidance Negative Regulation Of Neuron Projection Development Spinal Cord Ventral Commissure Morphogenesis Dorsal/ventral Axon Guidance Anterior/posterior Axon Guidance Netrin-activated Signaling Pathway Negative Regulation Of Collateral Sprouting Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Postsynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Neuron Death Negative Regulation Of Netrin-activated Signaling Pathway Negative Regulation Of Dendrite Development
Pathways		Adenosine P1 receptors G alpha (s) signalling events Surfactant metabolism ADORA2B mediated anti-inflammatory cytokines production	Netrin-1 signaling Netrin-1 signaling DSCAM interactions DCC mediated attractive signaling DCC mediated attractive signaling Netrin mediated repulsion signals Caspase activation via Dependence Receptors in the absence of ligand Role of second messengers in netrin-1 signaling Regulation of commissural axon pathfinding by SLIT and ROBO
Drugs		Theophylline Adenosine Enprofylline Defibrotide
Diseases			Colorectal cancer Gastric cancer Cancer of the anal canal
GWAS		Immune reponse to smallpox (secreted IL-12p40) ( 22610502)	Age at first sexual intercourse ( 27089180) Alcoholism (alcohol use disorder factor score) ( 21529783) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Benign prostatic hyperplasia ( 30988330) Body mass index ( 28892062) Body mass index (ever vs never smoking interaction) ( 23192594) Bortezomib-induced peripheral neuropathy in multiple myeloma ( 28317148) Chronic back pain ( 30261039) Coenzyme Q10 levels ( 27149984) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Depression ( 27089181 29700475) Experiencing mood swings ( 29500382) Feeling fed-up ( 29500382) Feeling miserable ( 29500382) Gallbladder cancer ( 22318345) General cognitive ability ( 29844566) General factor of neuroticism ( 30867560) Glucose homeostasis traits ( 25524916) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Intraocular pressure ( 30591961) Lung function (FVC) ( 30061609 30804560) Mood instability ( 31168069 29187730) Mosquito bite size ( 28199695) Multisite chronic pain ( 31194737) Neurociticism ( 29500382) Nickel levels ( 26025379) Number of sexual partners ( 30643258) Obesity-related traits ( 23251661) Putamen volume ( 29147026) Response to exercise (triglyceride level interaction) ( 26491034) Response to fenofibrate (total cholesterol levels) ( 27002377) Response to mTOR inhibitor (everolimus) ( 24009623) Risk-taking tendency (4-domain principal component model) ( 30643258) Schizophrenia ( 30285260) Short-term memory (digit-span task) ( 30741946) Smoking behaviour (cigarettes smoked per day) ( 27393504) Smoking status (ever vs never smokers) ( 30643258) Subcortical brain region volumes ( 25607358) Survival in colorectal cancer (distant metastatic) ( 26586795)
Interacting Genes		7 interacting genes: ADA DCC EZR NTN1 SLC9A3R2 TPD52L2 ZNF267	15 interacting genes: ADORA2B APPL1 AR BARD1 CASP3 CASP9 MAPK3 MAZ NCK1 NTN1 PITPNA PTK2 RPL5 SIAH1 SIAH2
Entrez ID		136	1630
HPRD ID		15971	00391
Ensembl ID		ENSG00000170425	ENSG00000187323
Uniprot IDs		P29275	P43146 Q49AK4
PDB IDs			2ED7 2ED8 2ED9 2EDB 2EDD 2EDE 3AU4 4URT 5X83
Enriched GO Terms of Interacting Partners?
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