PHB2 and FHL2

Number of citations of the paper that reports this interaction (PubMedID 18255255)
8

Data Source:
BioGRID (two hybrid)

		PHB2	FHL2
Description		prohibitin 2	four and a half LIM domains 2
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Cell Surface Postsynaptic Density Nuclear Matrix Axon Protein-containing Complex Presynaptic Active Zone Cell Periphery Glutamatergic Synapse GABA-ergic Synapse	Nucleus Nucleoplasm Focal Adhesion Z Disc M Band
	Molecular Function	Protein Binding Protein C-terminus Binding Estrogen Receptor Binding Amide Binding Sphingolipid Binding Protein N-terminus Binding	Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Transcription Factor Binding Identical Protein Binding Metal Ion Binding Androgen Receptor Binding
	Biological Process	Protein Import Into Nucleus Mitochondrial Calcium Ion Transmembrane Transport Mitochondrion Organization Sister Chromatid Cohesion Response To Wounding Regulation Of Complement Activation Positive Regulation Of Exit From Mitosis Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Negative Regulation Of Apoptotic Process Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Transcription, DNA-templated Protein Stabilization Positive Regulation Of DNA-binding Transcription Factor Activity Mammary Gland Branching Involved In Thelarche Mammary Gland Alveolus Development Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Retinoic Acid Cellular Response To Hypoxia Positive Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Cytochrome-c Oxidase Activity	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Response To Hormone Regulation Of Lipid Metabolic Process Androgen Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription, DNA-templated Atrial Cardiac Muscle Cell Development Ventricular Cardiac Muscle Cell Development Heart Trabecula Formation Negative Regulation Of Calcineurin-NFAT Signaling Cascade
Pathways		Processing of SMDT1	PPARA activates gene expression
Drugs		Capsaicin
Diseases
GWAS		Glycated hemoglobin levels ( 28898252) Red blood cell fatty acid levels ( 25500335)	Body fat mass ( 28552196) Household income (MTAG) ( 31844048) Lung cancer in ever smokers ( 28604730) Pulse pressure ( 30224653 30578418)
Interacting Genes		19 interacting genes: AFP AKT1 ESR1 EZH2 FHL2 HDAC1 HDAC2 HDAC3 HDAC5 MEF2A MYOD1 NR2F1 NR2F2 PPARG PRKCA PTMA RNF2 TEAD3 UPF2	98 interacting genes: ADAM17 AK1 APP AR ARHGAP9 ATXN1 BANP BIN1 BLZF1 BMPR2 BRCA1 CAPN1 CARD8 CCDC92 CKM CREBBP CSK CSN2 CTNNB1 DCP1A DPF2 DTX2 DUSP10 E2F1 E2F2 E2F3 E2F4 EP300 ESR1 FHL1 FHL3 FHL5 FOXO1 GLYR1 GNG12 HAND1 HCK HSPB2 ID3 IDH1 IER3 IGFBP5 IKZF4 INCA1 ITGA3 ITGA7 ITGB1 ITGB2 ITGB5 ITGB6 JUP KANK2 KIAA1217 MCM7 MDM2 MYBPC1 NIBAN1 NRF1 PFKM PHB2 PSEN2 PUF60 RAI2 REL REV1 RFX3 RUNX2 SAP30BP SAXO1 SFPQ SIGLEC6 SLC34A1 SMAD2 SMAD3 SMAD4 SP2 SRF STAT3 SUMO1P1 TNFRSF11A TRAF6 TRIM55 TRIM63 TTN WT1 ZBTB16 ZBTB25 ZFP64 ZFYVE9 ZMYM4 ZNF131 ZNF212 ZNF3 ZNF331 ZNF408 ZNF417 ZNF626 ZNF638
Entrez ID		11331	2274
HPRD ID		17843	04026
Ensembl ID		ENSG00000215021	ENSG00000115641
Uniprot IDs		Q99623	Q14192 Q2XQU9 Q6I9R8
PDB IDs		6IQE	1X4K 1X4L 2D8Z 2MIU
Enriched GO Terms of Interacting Partners?
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