AGR2 and GPSM2

Number of citations of the paper that reports this interaction (PubMedID 20888340)
17

Data Source:
BioGRID (two hybrid)

		AGR2	GPSM2
Description		anterior gradient 2, protein disulphide isomerase family member	G protein signaling modulator 2
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GO Annotations	Cellular Component	Extracellular Space Endoplasmic Reticulum	Cell Cytoplasm Centrosome Cytosol Cell Cortex Lateral Plasma Membrane Protein-containing Complex Mitotic Spindle Pole Lateral Cell Cortex Cell Cortex Region
	Molecular Function	Dystroglycan Binding Epidermal Growth Factor Receptor Binding Protein Binding Identical Protein Binding	Nucleotide Binding G-protein Alpha-subunit Binding GDP-dissociation Inhibitor Activity Protein Binding Protein C-terminus Binding Protein Domain Specific Binding Identical Protein Binding Protein Self-association Dynein Complex Binding
	Biological Process	Positive Regulation Of Gene Expression Positive Regulation Of Cell-substrate Adhesion Response To Endoplasmic Reticulum Stress Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Digestive Tract Morphogenesis Positive Regulation Of Developmental Growth Lung Goblet Cell Differentiation Negative Regulation Of Cell Death Mucus Secretion Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of IRE1-mediated Unfolded Protein Response Positive Regulation Of PERK-mediated Unfolded Protein Response	Establishment Of Mitotic Spindle Orientation Mitotic Spindle Organization G Protein-coupled Receptor Signaling Pathway Ran Protein Signal Transduction Regulation Of Catalytic Activity Cell Division Maintenance Of Centrosome Location Regulation Of Mitotic Spindle Organization Positive Regulation Of Protein Localization To Cell Cortex Positive Regulation Of Spindle Assembly
Pathways			G alpha (i) signalling events
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) ( 23648065) Iron status biomarkers (ferritin levels) ( 28334935) Residual cognition ( 28441426) Type 2 diabetes (dietary heme iron intake interaction) ( 23386860)	Fat distribution (HIV) ( 21897333)
Interacting Genes		20 interacting genes: APP BRD7 CATSPER1 CCDC90B CKAP2 CRMP1 DAG1 FABP2 GPSM2 KRT31 LYPD3 MED31 MLH1 NRIP1 NUP62CL POM121 RUVBL2 TMEM123 UBQLN1 UBQLN4	10 interacting genes: AGR2 CLCC1 GLIS2 GNAI1 GNAI2 GNAI3 GNAO1 HRAS INSC NUMA1
Entrez ID		10551	29899
HPRD ID		05896	06609
Ensembl ID		ENSG00000106541	ENSG00000121957
Uniprot IDs		O95994 Q4JM46	A0A024R0F8 B4DIF1 P81274
PDB IDs		2LNS 2LNT	3SF4 4WND 4WNE 4WNF 4WNG 5A6C 6HC2
Enriched GO Terms of Interacting Partners?
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