AGR2 and LYPD3

Number of citations of the paper that reports this interaction (PubMedID 12592373)
48

Data Source:
BioGRID (two hybrid, two hybrid)

		AGR2	LYPD3
Description		anterior gradient 2, protein disulphide isomerase family member	LY6/PLAUR domain containing 3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Endoplasmic Reticulum	Extracellular Region Extracellular Space Plasma Membrane Integral Component Of Membrane Anchored Component Of Plasma Membrane
	Molecular Function	Dystroglycan Binding Epidermal Growth Factor Receptor Binding Protein Binding Identical Protein Binding	Laminin Binding
	Biological Process	Positive Regulation Of Gene Expression Positive Regulation Of Cell-substrate Adhesion Response To Endoplasmic Reticulum Stress Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Digestive Tract Morphogenesis Positive Regulation Of Developmental Growth Lung Goblet Cell Differentiation Negative Regulation Of Cell Death Mucus Secretion Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of IRE1-mediated Unfolded Protein Response Positive Regulation Of PERK-mediated Unfolded Protein Response	Cell-matrix Adhesion
Pathways			Post-translational modification: synthesis of GPI-anchored proteins
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) ( 23648065) Iron status biomarkers (ferritin levels) ( 28334935) Residual cognition ( 28441426) Type 2 diabetes (dietary heme iron intake interaction) ( 23386860)	Cotinine glucuronidation ( 25293881)
Interacting Genes		20 interacting genes: APP BRD7 CATSPER1 CCDC90B CKAP2 CRMP1 DAG1 FABP2 GPSM2 KRT31 LYPD3 MED31 MLH1 NRIP1 NUP62CL POM121 RUVBL2 TMEM123 UBQLN1 UBQLN4	17 interacting genes: AGR2 AGR3 AURKA BAG4 BRMS1 CASP8 CHEK2 CTRB1 ERBB2 IGF1R LSP1 PALB2 PPM1D PTPRJ RB1CC1 SMAD4 STK11
Entrez ID		10551	27076
HPRD ID		05896	10783
Ensembl ID		ENSG00000106541	ENSG00000124466
Uniprot IDs		O95994 Q4JM46	B2RBR3 O95274
PDB IDs		2LNS 2LNT
Enriched GO Terms of Interacting Partners?
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