AGR2 and BRD7

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		AGR2	BRD7
Description		anterior gradient 2, protein disulphide isomerase family member	bromodomain containing 7
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GO Annotations	Cellular Component	Extracellular Space Endoplasmic Reticulum	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Dystroglycan Binding Epidermal Growth Factor Receptor Binding Protein Binding Identical Protein Binding	P53 Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Transcription Factor Binding Histone Binding Transcription Regulatory Region DNA Binding Lysine-acetylated Histone Binding
	Biological Process	Positive Regulation Of Gene Expression Positive Regulation Of Cell-substrate Adhesion Response To Endoplasmic Reticulum Stress Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Digestive Tract Morphogenesis Positive Regulation Of Developmental Growth Lung Goblet Cell Differentiation Negative Regulation Of Cell Death Mucus Secretion Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of IRE1-mediated Unfolded Protein Response Positive Regulation Of PERK-mediated Unfolded Protein Response	Regulation Of Transcription By RNA Polymerase II Cell Cycle Negative Regulation Of Cell Proliferation Wnt Signaling Pathway Positive Regulation Of Histone Acetylation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways			Regulation of TP53 Activity through Acetylation
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) ( 23648065) Iron status biomarkers (ferritin levels) ( 28334935) Residual cognition ( 28441426) Type 2 diabetes (dietary heme iron intake interaction) ( 23386860)	Allergic sensitization ( 30013184) Epilepsy ( 30531953) Liver enzyme levels (alanine transaminase) ( 24124411) Medication use (thyroid preparations) ( 31015401)
Interacting Genes		20 interacting genes: APP BRD7 CATSPER1 CCDC90B CKAP2 CRMP1 DAG1 FABP2 GPSM2 KRT31 LYPD3 MED31 MLH1 NRIP1 NUP62CL POM121 RUVBL2 TMEM123 UBQLN1 UBQLN4	30 interacting genes: AGR2 BARD1 BHLHE40 BRD3 BTBD2 DVL1 FTH1 H2AC16 H2BC21 H3-3A H3-4 H3C14 H4-16 HAP1 HNRNPUL1 IRF2 LAMA4 LRIF1 MX1 NEFL PAFAH1B3 PCBD1 PSMD11 PTPN13 RBFOX2 RIF1 RPLP1 SERPINB9 TP53 TRIM24
Entrez ID		10551	29117
HPRD ID		05896	12531
Ensembl ID		ENSG00000106541	ENSG00000166164
Uniprot IDs		O95994 Q4JM46	Q9NPI1
PDB IDs		2LNS 2LNT	2I7K 5MQ1
Enriched GO Terms of Interacting Partners?
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