UBAC1 and TRIM2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid, two hybrid)

		UBAC1	TRIM2
Description		UBA domain containing 1	tripartite motif containing 2
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Cytosol Plasma Membrane Extracellular Exosome	Cytoplasm
	Molecular Function	Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Ubiquitination	Protein Polyubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Neuron Apoptotic Process
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Interferon gamma signaling
Drugs
Diseases
GWAS		Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Ulcerative colitis ( 28067908)	HDL cholesterol ( 30275531) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heel bone mineral density ( 30598549) LDL cholesterol levels ( 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Multiple sclerosis ( 21654844)
Interacting Genes		19 interacting genes: AIRE APP CDKN1B CPSF6 CSNK2A1 DAZAP2 DVL2 HTT LAPTM5 MAP3K1 NEDD4L PMPCA RNF11 RNF123 SMURF1 TRIM2 TRIM39 UBC ZDHHC17	25 interacting genes: BCL2L11 CDK20 CIB3 DTNBP1 GJB5 LRRC8E MNAT1 MYO5A OTUB2 SIRPA TNFAIP3 TNIK TRIM8 UBAC1 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2K UBE2U UBE2W
Entrez ID		10422	23321
HPRD ID		12170	10279
Ensembl ID		ENSG00000130560	ENSG00000109654
Uniprot IDs		A0A140VK64 Q9BSL1	Q9C040
PDB IDs		2DAI
Enriched GO Terms of Interacting Partners?
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Tagcloud (Difference) ?
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