TRIM2 and LRRC8E

Number of citations of the paper that reports this interaction (PubMedID 21516116)
94

Data Source:
BioGRID (two hybrid)

		TRIM2	LRRC8E
Description		tripartite motif containing 2	leucine rich repeat containing 8 VRAC subunit E
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Cytoplasm Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Ion Channel Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity	Volume-sensitive Anion Channel Activity Protein Binding
	Biological Process	Protein Polyubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Neuron Apoptotic Process	Inorganic Anion Transport Aspartate Transmembrane Transport Transmembrane Transport Cellular Response To Osmotic Stress Anion Transmembrane Transport
Pathways		Interferon gamma signaling	Miscellaneous transport and binding events
Drugs
Diseases			Agammaglobulinemias, including the following six diseases: X-linked agammaglobulinemia (Bruton's agammaglobulinemia, XLA); IgM heavy chain gene deletions; Ig-alpha defect; Autosomal recessive agammaglobulinaemia; B cell-linker protein (BLNK) deficiency; Leucine-rich repeat-containing 8
GWAS		HDL cholesterol ( 30275531) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heel bone mineral density ( 30598549) LDL cholesterol levels ( 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Multiple sclerosis ( 21654844)
Interacting Genes		25 interacting genes: BCL2L11 CDK20 CIB3 DTNBP1 GJB5 LRRC8E MNAT1 MYO5A OTUB2 SIRPA TNFAIP3 TNIK TRIM8 UBAC1 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2K UBE2U UBE2W	3 interacting genes: FBXO7 LNX2 TRIM2
Entrez ID		23321	80131
HPRD ID		10279	08670
Ensembl ID		ENSG00000109654	ENSG00000171017
Uniprot IDs		Q9C040	Q6NSJ5
PDB IDs
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?