|
|
MAPKAPK5 |
MAPK activated protein kinase 5 |
- Oxidative Stress Induced Senescence
- MAPK6/MAPK4 signaling
- Regulation of TP53 Activity through Phosphorylation
|
|
|
|
|
MDC1 |
mediator of DNA damage checkpoint 1 |
- SUMOylation of DNA damage response and repair proteins
- Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
- Nonhomologous End-Joining (NHEJ)
- Processing of DNA double-strand break ends
- TP53 Regulates Transcription of DNA Repair Genes
- G2/M DNA damage checkpoint
|
|
|
|
|
MDH1 |
malate dehydrogenase 1 |
|
- NADH
- Nicotinamide adenine dinucleotide phosphate
- Artenimol
|
|
|
|
MDM2 |
MDM2 proto-oncogene |
- AKT phosphorylates targets in the cytosol
- Oxidative Stress Induced Senescence
- Oncogene Induced Senescence
- SUMOylation of transcription factors
- SUMOylation of ubiquitinylation proteins
- Trafficking of AMPA receptors
- Constitutive Signaling by AKT1 E17K in Cancer
- Ub-specific processing proteases
- Regulation of TP53 Activity through Phosphorylation
- Regulation of TP53 Degradation
- Regulation of TP53 Activity through Methylation
- Stabilization of p53
- Regulation of RUNX3 expression and activity
|
- Zinc
- Cis-[4,5-Bis-(4-Bromophenyl)-2-(2-Ethoxy-4-Methoxyphenyl)-4,5-Dihydroimidazol-1-Yl]-[4-(2-Hydroxyethyl)Piperazin-1-Yl]Methanone
- Cis-[4,5-Bis-(4-Chlorophenyl)-2-(2-Isopropoxy-4-Methoxyphenyl)-4,5-Dihyd Roimidazol-1-Yl]-Piperazin-1-Yl-Methanone
- Zinc acetate
- Zinc chloride
- Zinc sulfate, unspecified form
|
- Choriocarcinoma
- Osteosarcoma
- Glioma
- Penile cancer
- Alveolar rhabdomyosarcoma
|
|
|
MDM4 |
MDM4 regulator of p53 |
- Oxidative Stress Induced Senescence
- Oncogene Induced Senescence
- Ub-specific processing proteases
- Regulation of TP53 Activity through Phosphorylation
- Regulation of TP53 Degradation
- Regulation of TP53 Activity through Methylation
- Stabilization of p53
|
|
|
|
|
MED1 |
mediator complex subunit 1 |
- RORA activates gene expression
- BMAL1:CLOCK,NPAS2 activates circadian gene expression
- PPARA activates gene expression
- PPARA activates gene expression
- Generic Transcription Pathway
- Transcriptional activation of mitochondrial biogenesis
- Activation of gene expression by SREBF (SREBP)
- Transcriptional regulation of white adipocyte differentiation
- Transcriptional regulation of white adipocyte differentiation
- Nuclear Receptor transcription pathway
- Regulation of lipid metabolism by PPARalpha
- Circadian Clock
- Estrogen-dependent gene expression
|
|
|
|
|
MED17 |
mediator complex subunit 17 |
- PPARA activates gene expression
- Generic Transcription Pathway
- Transcriptional regulation of white adipocyte differentiation
- Transcriptional regulation of white adipocyte differentiation
|
|
|
|
|
MED21 |
mediator complex subunit 21 |
- PPARA activates gene expression
- Transcriptional regulation of white adipocyte differentiation
- Transcriptional regulation of white adipocyte differentiation
|
|
|
|
|
MEN1 |
menin 1 |
- Formation of the beta-catenin:TCF transactivating complex
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- Deactivation of the beta-catenin transactivating complex
- Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
- RHO GTPases activate IQGAPs
- Post-translational protein phosphorylation
|
|
- Carcinoid
- Adrenal carcinoma
- Primary hyperparathyroidism; Familial hyperparathyroidism (HRPT)
- Malignant islet cell carcinoma
|
|
|
MET |
MET proto-oncogene, receptor tyrosine kinase |
- PIP3 activates AKT signaling
- Constitutive Signaling by Aberrant PI3K in Cancer
- Sema4D mediated inhibition of cell attachment and migration
- RAF/MAP kinase cascade
- MET Receptor Activation
- Negative regulation of MET activity
- PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
- MET activates RAS signaling
- MET activates PI3K/AKT signaling
- MET activates PTPN11
- MET activates PTK2 signaling
- InlB-mediated entry of Listeria monocytogenes into host cell
- InlB-mediated entry of Listeria monocytogenes into host cell
- MET interacts with TNS proteins
- MET activates RAP1 and RAC1
- MET receptor recycling
- MET activates STAT3
- MECP2 regulates neuronal receptors and channels
|
- K-252a
- SGX-523
- 1-(4-fluorophenyl)-N-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide
- N-({4-[(2-aminopyridin-4-yl)oxy]-3-fluorophenyl}carbamoyl)-2-(4-fluorophenyl)acetamide
- 2-(4-fluorophenyl)-N-{[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]carbamoyl}acetamide
- N-(3-chlorophenyl)-N-methyl-2-oxo-3-[(3,4,5-trimethyl-1H-pyrrol-2-yl)methyl]-2H-indole-5-sulfonamide
- 3-[3-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)quinoxalin-5-yl]phenol
- AMG-208
- 1-[(2-NITROPHENYL)SULFONYL]-1H-PYRROLO[3,2-B]PYRIDINE-6-CARBOXAMIDE
- Crizotinib
- Cabozantinib
- Capmatinib
- Fostamatinib
- Tivantinib
- Brigatinib
- Amuvatinib
|
- Renal cell carcinoma
- Cholangiocarcinoma
- Gastric cancer
|
|
|
MIF |
macrophage migration inhibitory factor |
- Cell surface interactions at the vascular wall
- Neutrophil degranulation
- Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
|
- 3,4-Dihydroxycinnamic Acid
- 7-Hydroxy-2-Oxo-Chromene-3-Carboxylic Acid Ethyl Ester
- 4-Hydroxyphenylpyruvic acid
- 3-(4-HYDROXYPHENYL)-4,5-DIHYDRO-5-ISOXAZOLE-ACETIC ACID METHYL ESTER
- 4-HYDROXYBENZALDEHYDE O-(CYCLOHEXYLCARBONYL)OXIME
- 3-FLUORO-4-HYDROXYBENZALDEHYDE O-(CYCLOHEXYLCARBONYL)OXIME
- 4-HYDROXYBENZALDEHYDE O-(3,3-DIMETHYLBUTANOYL)OXIME
- 6-HYDROXY-1,3-BENZOTHIAZOLE-2-SULFONAMIDE
|
|
|
|
MKRN2 |
makorin ring finger protein 2 |
|
|
|
|
|
MNAT1 |
MNAT1 component of CDK activating kinase |
- Formation of RNA Pol II elongation complex
- Formation of the Early Elongation Complex
- Formation of HIV elongation complex in the absence of HIV Tat
- Formation of the HIV-1 Early Elongation Complex
- RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
- HIV Transcription Initiation
- RNA Polymerase II HIV Promoter Escape
- Transcription of the HIV genome
- Formation of HIV-1 elongation complex containing HIV-1 Tat
- Tat-mediated elongation of the HIV-1 transcript
- NoRC negatively regulates rRNA expression
- Formation of Incision Complex in GG-NER
- RNA Polymerase II Pre-transcription Events
- Formation of TC-NER Pre-Incision Complex
- Transcription-Coupled Nucleotide Excision Repair (TC-NER)
- Dual incision in TC-NER
- Gap-filling DNA repair synthesis and ligation in TC-NER
- TP53 Regulates Transcription of DNA Repair Genes
- Cyclin E associated events during G1/S transition
- Cyclin D associated events in G1
- Cyclin A/B1/B2 associated events during G2/M transition
- Cyclin A:Cdk2-associated events at S phase entry
- mRNA Capping
- RNA Polymerase I Transcription Initiation
- RNA Polymerase I Promoter Escape
- RNA Polymerase II Promoter Escape
- RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
- RNA Polymerase I Transcription Termination
- RNA Polymerase II Transcription Initiation
- RNA Polymerase II Transcription Elongation
- RNA Polymerase II Transcription Initiation And Promoter Clearance
- RNA Pol II CTD phosphorylation and interaction with CE
- RUNX1 regulates transcription of genes involved in differentiation of HSCs
|
|
|
|
|
MNDA |
myeloid cell nuclear differentiation antigen |
|
|
|
|
|
MPHOSPH6 |
M-phase phosphoprotein 6 |
- Major pathway of rRNA processing in the nucleolus and cytosol
|
|
|
|
|
MSL2 |
MSL complex subunit 2 |
|
|
|
|
|
MSX1 |
msh homeobox 1 |
|
|
- Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate
- Tooth agenesis; Hypodontia
- Tooth and nail syndrome; Witkop syndrome
|
|
|
MTA1 |
metastasis associated 1 |
- HDACs deacetylate histones
- SUMOylation of transcription factors
- ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
- RNA Polymerase I Transcription Initiation
- Regulation of PTEN gene transcription
- Regulation of PTEN gene transcription
- Potential therapeutics for SARS
|
|
|
|
|
MTA2 |
metastasis associated 1 family member 2 |
- HDACs deacetylate histones
- ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
- Regulation of TP53 Activity through Acetylation
- RNA Polymerase I Transcription Initiation
- Regulation of PTEN gene transcription
- Regulation of PTEN gene transcription
- Potential therapeutics for SARS
|
|
|
|
|
MUC1 |
mucin 1, cell surface associated |
- Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)
- Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)
- Defective GALNT12 causes colorectal cancer 1 (CRCS1)
- Dectin-2 family
- Interleukin-4 and Interleukin-13 signaling
- O-linked glycosylation of mucins
- Termination of O-glycan biosynthesis
|
|
|