Search Results for: TERT

89 interactions involving TERT - telomerase reverse transcriptase found:

Sort by: Symbol Number of Pathways Number of Drugs Number of Diseases
Novel Interactant Symbol Name
Associated Pathways
Binding Drugs
Associated Diseases
GLIS2 GLIS family zinc finger 2
  • Nephronophthisis-medullary cystic kidney disease, including; Nephronophthisis (NPH) ; Nephronophthisis-like nephropathy 1; Medullary cystic kidney disease 1; Medullary cystic kidney disease 2 (MSKD2)
IREB2 iron responsive element binding protein 2
  • Iron uptake and transport
MAP3K5 mitogen-activated protein kinase kinase kinase 5
  • Oxidative Stress Induced Senescence
  • Oxidative Stress Induced Senescence
MCRS1 microspherule protein 1
  • HATs acetylate histones
  • UCH proteinases
  • DNA Damage Recognition in GG-NER
NCL nucleolin
  • Major pathway of rRNA processing in the nucleolus and cytosol
NF2 neurofibromin 2
  • Regulation of actin dynamics for phagocytic cup formation
  • RHO GTPases activate PAKs
  • Malignant pleural mesothelioma
  • Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
NSD3 nuclear receptor binding SET domain protein 3
  • PKMTs methylate histone lysines
PABPC1 poly(A) binding protein cytoplasmic 1
  • L13a-mediated translational silencing of Ceruloplasmin expression
  • Deadenylation of mRNA
  • AUF1 (hnRNP D0) binds and destabilizes mRNA
  • Translation initiation complex formation
  • Regulation of expression of SLITs and ROBOs
  • Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
  • Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
PBK PDZ binding kinase
PFDN1 prefoldin subunit 1
  • Prefoldin mediated transfer of substrate to CCT/TriC
PHF20L1 PHD finger protein 20 like 1
PINX1 PIN2 (TERF1) interacting telomerase inhibitor 1
RASSF1 Ras association domain family member 1
  • Non-small cell lung cancer
  • Bladder cancer
  • Nasopharyngeal cancer
RPS6KB1 ribosomal protein S6 kinase B1
  • mTORC1-mediated signalling
RUVBL1 RuvB like AAA ATPase 1
  • Telomere Extension By Telomerase
  • Formation of the beta-catenin:TCF transactivating complex
  • Formation of the beta-catenin:TCF transactivating complex
  • HATs acetylate histones
  • UCH proteinases
  • Ub-specific processing proteases
  • DNA Damage Recognition in GG-NER
  • Deposition of new CENPA-containing nucleosomes at the centromere
SERBP1 SERPINE1 mRNA binding protein 1
SMG5 SMG5 nonsense mediated mRNA decay factor
  • Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
SOX3 SRY-box transcription factor 3
  • Deactivation of the beta-catenin transactivating complex
  • Septo-optic dysplasia
  • Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
  • 46,XX disorders of sex development (Disorders of gonadal development), including: Ovotesticular DSD; Testicular DSD; Ovarian dysgenesis
  • Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)
SOX4 SRY-box transcription factor 4
  • Deactivation of the beta-catenin transactivating complex
STEAP4 STEAP4 metalloreductase

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