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RUVBL2 |
RuvB like AAA ATPase 2 |
- Telomere Extension By Telomerase
- HATs acetylate histones
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SMG6 |
SMG6 nonsense mediated mRNA decay factor |
- Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
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XPO1 |
exportin 1 |
- Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
- Rev-mediated nuclear export of HIV RNA
- NEP/NS2 Interacts with the Cellular Export Machinery
- Downregulation of TGF-beta receptor signaling
- Separation of Sister Chromatids
- Resolution of Sister Chromatid Cohesion
- Deactivation of the beta-catenin transactivating complex
- HuR (ELAVL1) binds and stabilizes mRNA
- RHO GTPases Activate Formins
- MAPK6/MAPK4 signaling
- Mitotic Prometaphase
- Cyclin A/B1/B2 associated events during G2/M transition
- Estrogen-dependent nuclear events downstream of ESR-membrane signaling
- EML4 and NUDC in mitotic spindle formation
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YWHAQ |
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta |
- Activation of BAD and translocation to mitochondria
- Translocation of SLC2A4 (GLUT4) to the plasma membrane
- RHO GTPases activate PKNs
- TP53 Regulates Metabolic Genes
- Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
- Regulation of localization of FOXO transcription factors
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YWHAZ |
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta |
- Activation of BAD and translocation to mitochondria
- Translocation of SLC2A4 (GLUT4) to the plasma membrane
- Deactivation of the beta-catenin transactivating complex
- Rap1 signalling
- GP1b-IX-V activation signalling
- KSRP (KHSRP) binds and destabilizes mRNA
- Interleukin-3, Interleukin-5 and GM-CSF signaling
- RHO GTPases activate PKNs
- TP53 Regulates Metabolic Genes
- Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
- NOTCH4 Activation and Transmission of Signal to the Nucleus
- Negative regulation of NOTCH4 signaling
- Regulation of localization of FOXO transcription factors
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ACAA2 |
acetyl-CoA acyltransferase 2 |
- Mitochondrial Fatty Acid Beta-Oxidation
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CBLC |
Cbl proto-oncogene C |
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CCND2 |
cyclin D2 |
- Cyclin D associated events in G1
- Regulation of RUNX1 Expression and Activity
- Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
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CCNE1 |
cyclin E1 |
- G0 and Early G1
- SCF(Skp2)-mediated degradation of p27/p21
- DNA Damage/Telomere Stress Induced Senescence
- Association of TriC/CCT with target proteins during biosynthesis
- TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
- CDK-mediated phosphorylation and removal of Cdc6
- Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
- Cyclin E associated events during G1/S transition
- G1/S-Specific Transcription
- Cyclin D associated events in G1
- p53-Dependent G1 DNA Damage Response
- PTK6 Regulates Cell Cycle
- Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
- RHOBTB3 ATPase cycle
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- Laryngeal cancer
- Gastric cancer
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CCT5 |
chaperonin containing TCP1 subunit 5 |
- Prefoldin mediated transfer of substrate to CCT/TriC
- Formation of tubulin folding intermediates by CCT/TriC
- Folding of actin by CCT/TriC
- Association of TriC/CCT with target proteins during biosynthesis
- Association of TriC/CCT with target proteins during biosynthesis
- BBSome-mediated cargo-targeting to cilium
- Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
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CDKN2A |
cyclin dependent kinase inhibitor 2A |
- Oxidative Stress Induced Senescence
- Senescence-Associated Secretory Phenotype (SASP)
- Oncogene Induced Senescence
- Cyclin D associated events in G1
- Transcriptional Regulation by VENTX
- Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4
- Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6
- Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4
- Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6
- Apoptotic factor-mediated response
- Oxidative Stress Induced Senescence
- Oncogene Induced Senescence
- SUMOylation of DNA damage response and repair proteins
- SUMOylation of transcription factors
- Regulation of TP53 Degradation
- Stabilization of p53
- Regulation of RUNX3 expression and activity
- Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function
- Evasion of Oncogene Induced Senescence Due to p14ARF Defects
- Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects
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- Bladder cancer
- Type II diabetes mellitus
- Pancreatic cancer
- Burkitt lymphoma
- Adult T-cell leukemia
- Malignant pleural mesothelioma
- Non-small cell lung cancer
- Chronic myeloid leukemia (CML)
- Oral cancer
- Penile cancer
- Nasopharyngeal cancer
- Glioma
- Osteosarcoma
- Squamous cell carcinoma
- Cholangiocarcinoma
- Gallbladder cancer
- Malignant islet cell carcinoma
- Laryngeal cancer
- Hepatocellular carcinoma
- Esophageal cancer
- Malignant melanoma
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CDKN2B |
cyclin dependent kinase inhibitor 2B |
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- Oxidative Stress Induced Senescence
- Senescence-Associated Secretory Phenotype (SASP)
- Oncogene Induced Senescence
- Cyclin D associated events in G1
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- Malignant pleural mesothelioma
- Osteosarcoma
- Type II diabetes mellitus
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DACH1 |
dachshund family transcription factor 1 |
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DDX51 |
DEAD-box helicase 51 |
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DYNLL1 |
dynein light chain LC8-type 1 |
- Activation of BIM and translocation to mitochondria
- Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
- Macroautophagy
- MHC class II antigen presentation
- Separation of Sister Chromatids
- Resolution of Sister Chromatid Cohesion
- Regulation of PLK1 Activity at G2/M Transition
- HSP90 chaperone cycle for steroid hormone receptors (SHR)
- Loss of Nlp from mitotic centrosomes
- Recruitment of mitotic centrosome proteins and complexes
- Loss of proteins required for interphase microtubule organization from the centrosome
- Recruitment of NuMA to mitotic centrosomes
- Anchoring of the basal body to the plasma membrane
- Intraflagellar transport
- RHO GTPases Activate Formins
- Neutrophil degranulation
- COPI-mediated anterograde transport
- COPI-independent Golgi-to-ER retrograde traffic
- Mitotic Prometaphase
- AURKA Activation by TPX2
- HCMV Early Events
- Aggrephagy
- Aggrephagy
- EML4 and NUDC in mitotic spindle formation
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DYRK2 |
dual specificity tyrosine phosphorylation regulated kinase 2 |
- Regulation of TP53 Activity through Phosphorylation
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EIF2S1 |
eukaryotic translation initiation factor 2 subunit alpha |
- L13a-mediated translational silencing of Ceruloplasmin expression
- PERK regulates gene expression
- PERK regulates gene expression
- ABC-family proteins mediated transport
- Translation initiation complex formation
- Formation of the ternary complex, and subsequently, the 43S complex
- Ribosomal scanning and start codon recognition
- GTP hydrolysis and joining of the 60S ribosomal subunit
- Recycling of eIF2:GDP
- Response of EIF2AK4 (GCN2) to amino acid deficiency
- Response of EIF2AK1 (HRI) to heme deficiency
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FAAP24 |
FA core complex associated protein 24 |
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FOXO3 |
forkhead box O3 |
- Signaling by NODAL
- AKT phosphorylates targets in the nucleus
- Constitutive Signaling by AKT1 E17K in Cancer
- MAPK6/MAPK4 signaling
- Interleukin-4 and Interleukin-13 signaling
- Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
- Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
- RUNX3 regulates BCL2L11 (BIM) transcription
- FLT3 Signaling
- Regulation of localization of FOXO transcription factors
- FOXO-mediated transcription of cell death genes
- FOXO-mediated transcription of cell death genes
- FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
- FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
- Regulation of FOXO transcriptional activity by acetylation
- FOXO-mediated transcription of cell cycle genes
- FOXO-mediated transcription of cell cycle genes
- Estrogen-dependent nuclear events downstream of ESR-membrane signaling
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FZR1 |
fizzy and cell division cycle 20 related 1 |
- Autodegradation of Cdh1 by Cdh1:APC/C
- SCF-beta-TrCP mediated degradation of Emi1
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
- Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
- Regulation of APC/C activators between G1/S and early anaphase
- Phosphorylation of Emi1
- Senescence-Associated Secretory Phenotype (SASP)
- CDK-mediated phosphorylation and removal of Cdc6
- Cyclin A:Cdk2-associated events at S phase entry
- Transcriptional Regulation by VENTX
- Aberrant regulation of mitotic exit in cancer due to RB1 defects
- Antigen processing: Ubiquitination & Proteasome degradation
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