TERT and CDKN2B

Data Source:
BioGRID (fluorescent resonance energy transfer)

		TERT	CDKN2B
Description		telomerase reverse transcriptase	cyclin dependent kinase inhibitor 2B
Image			No pdb structure
GO Annotations	Cellular Component	Telomerase Catalytic Core Complex Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleus Nucleoplasm Telomerase Holoenzyme Complex Nucleolus Cytosol Plasma Membrane PML Body Nuclear Speck RNA-directed RNA Polymerase Complex Mitochondrial Nucleoid TERT-RMRP Complex	Nucleus Cytoplasm Cytosol
	Molecular Function	TRNA Binding Transcription Coactivator Binding DNA Binding Telomerase Activity Telomerase RNA Reverse Transcriptase Activity RNA Binding RNA-directed DNA Polymerase Activity RNA-directed 5'-3' RNA Polymerase Activity Protein Binding Protein C-terminus Binding Telomeric DNA Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein N-terminus Binding Chaperone Binding Telomerase RNA Binding Template-free RNA Nucleotidyltransferase	Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Protein Kinase Binding
	Biological Process	Telomere Maintenance Transcription, RNA-templated RNA-dependent DNA Biosynthetic Process Telomere Maintenance Via Telomerase Mitochondrion Organization Negative Regulation Of Gene Expression DNA Strand Elongation Positive Regulation Of Wnt Signaling Pathway Production Of SiRNA Involved In RNA Interference Regulation Of Protein Stability Positive Regulation Of Protein Binding Positive Regulation Of Hair Cycle Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Angiogenesis Positive Regulation Of Glucose Import Response To Cadmium Ion Positive Regulation Of Nitric-oxide Synthase Activity Double-stranded RNA Biosynthetic Process Establishment Of Protein Localization To Telomere Cellular Response To Hypoxia DNA Biosynthetic Process Replicative Senescence Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of Transdifferentiation Negative Regulation Of Production Of SiRNA Involved In RNA Interference Negative Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Protein Localization To Nucleolus Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Beta-catenin-TCF Complex Assembly Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Stem Cell Proliferation Negative Regulation Of Cellular Senescence Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G2/M Transition Of Mitotic Cell Cycle Cell Cycle Arrest Negative Regulation Of Cell Population Proliferation Megakaryocyte Differentiation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Extracellular Stimulus Cellular Response To Nutrient Negative Regulation Of Phosphorylation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Transcription By RNA Polymerase II Spleen Development Negative Regulation Of Epithelial Cell Proliferation Regulation Of G0 To G1 Transition Cellular Senescence Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Telomere Extension By Telomerase Formation of the beta-catenin:TCF transactivating complex	SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Cyclin D associated events in G1
Drugs		Zidovudine Grn163l Tertomotide
Diseases		Cri du chat syndrome; Cat cry syndrome; Chromosme 5p deletion syndrome	Malignant pleural mesothelioma Osteosarcoma Type II diabetes mellitus
GWAS		Adult diffuse glioma (IDH wildtype) ( 32386320) Adult diffuse glioma (TERT mutation only) ( 32386320) Basal cell carcinoma ( 31174203 19151717 24403052 25855136) Benign prostatic hyperplasia and lower urinary tract symptoms ( 30410027) Bladder cancer ( 24163127 20972438) Breast cancer ( 22037553 29059683 23535729 23535733 27117709 28171663) Breast cancer (estrogen-receptor negative) ( 27117709 28171663 29058716) Breast cancer (estrogen-receptor negative, progesterone-receptor negative, and human epidermal growth factor-receptor negative) ( 24325915) Breast Cancer in BRCA1 mutation carriers ( 29058716) Cancer (pleiotropy) ( 27197191) Chronic lymphocytic leukemia ( 28165464 26956414) Chronic lymphocytic leukemia or systemic lupus erythematosus ( 31407831) Colorectal cancer ( 30529582 31826910) Colorectal cancer or advanced adenoma ( 30510241) Cutaneous malignant melanoma ( 32341527) EGFR mutation-positive lung adenocarcinoma ( 27501781) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Epithelial ovarian cancer ( 25581431) Glioblastoma ( 28346443 29743610) Glioblastoma (age-stratified) ( 30152087) Glioma ( 30714141 28346443 21827660 21531791 22886559 29743610 19578367) Glioma (high-grade) ( 24908248) Granulocyte count ( 27863252) HDL cholesterol levels ( 32203549) Hematocrit ( 32888494) Idiopathic pulmonary fibrosis ( 31710517 18835860) Interstitial lung disease ( 23583980) Intrinsic epigenetic age acceleration ( 29374233) Keratinocyte cancer (MTAG) ( 31174203) Leukocyte telomere length ( 32109421 31171785) Lung adenocarcinoma ( 20700438 28604730 19836008 22797724 20871597 27393504) Lung cancer ( 21725308 23143601 27393504 18978790) Lung cancer in never smokers ( 31009812 28604730) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 29403010 32888494 27863252 28017375) Mean corpuscular volume ( 29403010 32888494 27863252 28017375) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Melanoma ( 21983787 28212542) Monocyte percentage of white cells ( 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Multiple sclerosis ( 31604244) Myeloid white cell count ( 27863252) Myeloproliferative neoplasms ( 33057200) Nasopharyngeal carcinoma ( 27436580 26545403) Neutrophil count ( 29403010 32888494 27863252) Neutrophil percentage of white cells ( 32888494 27863252) Nevus count or cutaneous melanoma ( 30429480) Non-albumin protein levels ( 29403010) Non-glioblastoma glioma ( 28346443 29743610) Non-small cell lung cancer ( 31326317) Pancreatic cancer ( 29422604 27579533 25086665) Platelet count ( 29403010 32888494 27863252) Plateletcrit ( 32888494 27863252) Prostate cancer ( 31562322 21743467 25939597) Prostate-specific antigen levels ( 30410027 28139693) Red blood cell count ( 29403010 32888494 20139978 27863252) Serum prostate-specific antigen levels ( 21160077) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systolic blood pressure ( 30224653) Telomere length ( 24465473 29151059) Testicular germ cell cancer ( 20543847) Testicular germ cell tumor ( 28604728 28604732 23666240) Thyroid cancer ( 28195142) Uterine fibroids ( 30194396 31649266) Uveal melanoma ( 28781888) White blood cell count ( 29403010 32888494 27863252)	Ankle-brachial index ( 22199011) Basal cell carcinoma ( 24403052 25855136 27539887) Breast cancer ( 29059683 23535729 20453838) Cancer ( 27197191) Cancer (pleiotropy) ( 27197191) Carotid plaque burden ( 28282560) Chronic lymphocytic leukemia ( 23770605) Coronary artery calcification ( 22144573 23561647) Coronary artery disease ( 21239051 29263402 26708285 29212778) Coronary heart disease ( 21971053 17554300 21378990 29615537) Coronary heart disease (SNP X SNP interaction) ( 21626137) Coronary heart disease x type 2 diabetes interaction ( 32541925) Cutaneous malignant melanoma ( 32341527) Endometrial cancer ( 30093612) Endometrial cancer (endometrioid histology) ( 30093612) Endometriosis ( 23104006) Esophageal squamous cell carcinoma ( 25129146) Facial pigmentation measurement (polar light) ( 32835660) Facial pigmentation measurement (UV light) ( 32835660) Fasting blood glucose ( 25631608 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting plasma glucose ( 25187374) Glaucoma ( 22792221) Glaucoma (primary open-angle) ( 22419738) Glioblastoma ( 28346443) Glioblastoma (age-stratified) ( 30152087) Glioma ( 28346443 21531791 19578367) Inflammatory bowel disease ( 27569725) Intracranial aneurysm ( 18997786 20364137) Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy) ( 27418160) Metabolite levels ( 23823483) Myocardial infarction ( 17478679) Myocardial infarction (early onset) ( 19198609) Nasopharyngeal carcinoma ( 20512145 26545403) Non-glioblastoma glioma ( 28346443) Non-melanoma skin cancer ( 29739929) Parental longevity (both parents in top 10%) ( 29227965) Parental longevity (father's age at death) ( 29227965) Psychosis proneness (hypomanic personality scale and perceptual aberration scale) ( 28525603) Psychosis proneness (hypomanic personality scale and revised physical anhedonia scale) ( 28525603) Psychosis proneness (hypomanic personality scale and revised social anhedonia scale) ( 28525603) Psychosis proneness (hypomanic personality scale) ( 28525603) Pulse pressure ( 27841878) Type 2 diabetes ( 21573907 27189021 18372903 24509480 26961502 29358691 30297969 26818947 23945395 22293688 22961080 20581827 19401414 17463246 30718926 17463248 17463249 19056611) Vertical cup-disc ratio ( 20548946)
Interacting Genes		80 interacting genes: ABL1 ACAA2 AKT1 ANXA2 ATP5F1B BECN1 BRAF CBLC CCND2 CCNE1 CCT5 CDK4 CDK6 CDKN2A CDKN2B CIB1 DACH1 DDX51 DYNLL1 DYRK2 EIF2S1 ENO1 FAAP24 FGFR4 FOXO3 FZR1 GLA GLIS2 GRM1 HSP90AA1 HSPA4 IREB2 MAP2K3 MAP2K5 MAP3K5 MCRS1 MDM2 MET MTOR MYC NCL NF2 NSD3 PABPC1 PBK PDGFRA PFDN1 PHF20L1 PINX1 PPIA PRKCA PTGES3 RAF1 RASSF1 RELA RPS6KB1 RUVBL1 RUVBL2 SERBP1 SLC7A11 SMG5 SMG6 SOX3 SOX4 SRC STEAP4 STK11 TEAD2 TEP1 TERF1 TGFBR2 TIMM21 TPP1 TUBA1B U2SURP XPO1 XRCC5 XRCC6 YWHAQ YWHAZ	64 interacting genes: AKT1 APP ARAF ARNT ARPC3 ATP6V1H BECN1 CBLC CCDC33 CCDC90B CCNC CCND2 CCNE1 CD44 CDK17 CDK4 CDK6 CDK8 CDKN2A CDKN2C CEP126 CNKSR3 ELP1 EPHA2 ERBB2 FGFR4 FZR1 GLIS2 GRM1 HGF HIF1A IGF1R INCA1 ISL1 KAT2A KDELR2 LATS2 MAGEA11 MAP2K3 MAP2K5 MAP2K6 MDM4 MET MYC NF2 NIF3L1 PDGFRA PICK1 PYCR3 RAF1 RASSF1 RTL8C RUSC1 SPG21 STK11 TEAD2 TERT TGFB1I1 TNFRSF1A TP53 TRAF1 TSC1 TTYH2 ZBTB17
Entrez ID		7015	1030
HPRD ID		01754	02696
Ensembl ID		ENSG00000164362	ENSG00000147883
Uniprot IDs		O14746	K7PPU3 P42772
PDB IDs		2BCK 4B18 4MNQ 5MEN 5MEO 5MEP 5MEQ 5MER 5UGW
Enriched GO Terms of Interacting Partners?
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