STK11 - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Associated Diseases Hide
CDKN2B	cyclin dependent kinase inhibitor 2B	SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Cyclin D associated events in G1	Malignant pleural mesothelioma Osteosarcoma Type II diabetes mellitus
CDKN2C	cyclin dependent kinase inhibitor 2C	Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Cyclin D associated events in G1
CFL2	cofilin 2		Nemaline myopathy
CRY2	cryptochrome circadian regulator 2	Circadian Clock
CYLC2	cylicin 2
D2HGDH	D-2-hydroxyglutarate dehydrogenase	Interconversion of 2-oxoglutarate and 2-hydroxyglutarate
DACH1	dachshund family transcription factor 1
EEF1A2	eukaryotic translation elongation factor 1 alpha 2	Eukaryotic Translation Elongation
ERLEC1	endoplasmic reticulum lectin 1	ABC-family proteins mediated transport Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Defective CFTR causes cystic fibrosis
ETV4	ETS variant transcription factor 4	MAPK6/MAPK4 signaling	Ewing's sarcoma Prostate cancer
FAIM2	Fas apoptotic inhibitory molecule 2
FBP2	fructose-bisphosphatase 2	Gluconeogenesis
FZR1	fizzy and cell division cycle 20 related 1	Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase Phosphorylation of Emi1 Senescence-Associated Secretory Phenotype (SASP) CDK-mediated phosphorylation and removal of Cdc6 Cyclin A:Cdk2-associated events at S phase entry Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
GLIS2	GLIS family zinc finger 2		Nephronophthisis-medullary cystic kidney disease, including; Nephronophthisis (NPH) ; Nephronophthisis-like nephropathy 1; Medullary cystic kidney disease 1; Medullary cystic kidney disease 2 (MSKD2)
HERC2	HECT and RLD domain containing E3 ubiquitin protein ligase 2	SUMOylation of DNA damage response and repair proteins Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint Antigen processing: Ubiquitination & Proteasome degradation
KDELR2	KDEL endoplasmic reticulum protein retention receptor 2	COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic
LATS2	large tumor suppressor kinase 2	Signaling by Hippo
LYPD3	LY6/PLAUR domain containing 3	Post-translational modification: synthesis of GPI-anchored proteins
MAP3K5	mitogen-activated protein kinase kinase kinase 5	Oxidative Stress Induced Senescence Oxidative Stress Induced Senescence
MAPRE1	microtubule associated protein RP/EB family member 1	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 EML4 and NUDC in mitotic spindle formation

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