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CASP10 |
caspase 10 |
- TP53 Regulates Transcription of Caspase Activators and Caspases
- FasL/ CD95L signaling
- TRAIL signaling
- NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
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- Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases: CD95 (Fas) defect, ALPS type 1a; CD95L (Fas ligand) defect, ALPS type 1b; Caspase 10 defect, ALPS type 2a; Caspase 8 defext, ALPS type 2b; Activaing N-Ras defect, N-Ras ALPS
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CASP2 |
caspase 2 |
- NOD1/2 Signaling Pathway
- NADE modulates death signalling
- TP53 Regulates Transcription of Caspase Activators and Caspases
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CASP6 |
caspase 6 |
- Apoptotic cleavage of cellular proteins
- Caspase-mediated cleavage of cytoskeletal proteins
- Breakdown of the nuclear lamina
- TP53 Regulates Transcription of Caspase Activators and Caspases
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CBX1 |
chromobox 1 |
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CBX4 |
chromobox 4 |
- Oxidative Stress Induced Senescence
- SUMOylation of DNA damage response and repair proteins
- SUMOylation of transcription cofactors
- SUMOylation of chromatin organization proteins
- SUMOylation of RNA binding proteins
- SUMOylation of DNA methylation proteins
- RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
- Regulation of PTEN gene transcription
- Regulation of PTEN gene transcription
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CCDC180 |
coiled-coil domain containing 180 |
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CCNA1 |
cyclin A1 |
- G0 and Early G1
- Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes
- Telomere Extension By Telomerase
- Cdc20:Phospho-APC/C mediated degradation of Cyclin A
- Regulation of APC/C activators between G1/S and early anaphase
- SCF(Skp2)-mediated degradation of p27/p21
- Senescence-Associated Secretory Phenotype (SASP)
- DNA Damage/Telomere Stress Induced Senescence
- Ub-specific processing proteases
- Processing of DNA double-strand break ends
- TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
- Regulation of TP53 Activity through Phosphorylation
- Regulation of TP53 Degradation
- G2 Phase
- Orc1 removal from chromatin
- CDK-mediated phosphorylation and removal of Cdc6
- G1/S-Specific Transcription
- Cyclin A/B1/B2 associated events during G2/M transition
- Cyclin A/B1/B2 associated events during G2/M transition
- p53-Dependent G1 DNA Damage Response
- Cyclin A:Cdk2-associated events at S phase entry
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CCNB1 |
cyclin B1 |
- E2F-enabled inhibition of pre-replication complex formation
- Polo-like kinase mediated events
- Golgi Cisternae Pericentriolar Stack Reorganization
- APC/C:Cdc20 mediated degradation of Cyclin B
- Regulation of APC/C activators between G1/S and early anaphase
- Phosphorylation of the APC/C
- Phosphorylation of Emi1
- Condensation of Prophase Chromosomes
- MASTL Facilitates Mitotic Progression
- Resolution of Sister Chromatid Cohesion
- Condensation of Prometaphase Chromosomes
- Regulation of PLK1 Activity at G2/M Transition
- Activation of NIMA Kinases NEK9, NEK6, NEK7
- Initiation of Nuclear Envelope (NE) Reformation
- Nuclear Pore Complex (NPC) Disassembly
- Depolymerisation of the Nuclear Lamina
- TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
- Mitotic Prophase
- Cyclin A/B1/B2 associated events during G2/M transition
- G2/M DNA replication checkpoint
- Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
- The role of GTSE1 in G2/M progression after G2 checkpoint
- Transcriptional regulation by RUNX2
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CCNC |
cyclin C |
- PPARA activates gene expression
- NOTCH1 Intracellular Domain Regulates Transcription
- Generic Transcription Pathway
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- Transcriptional regulation of white adipocyte differentiation
- Transcriptional regulation of white adipocyte differentiation
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CCND2 |
cyclin D2 |
- Cyclin D associated events in G1
- Regulation of RUNX1 Expression and Activity
- Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
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CCND3 |
cyclin D3 |
- Transcriptional regulation of white adipocyte differentiation
- MAPK6/MAPK4 signaling
- Cyclin D associated events in G1
- Regulation of RUNX1 Expression and Activity
- Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
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CCNE1 |
cyclin E1 |
- G0 and Early G1
- SCF(Skp2)-mediated degradation of p27/p21
- DNA Damage/Telomere Stress Induced Senescence
- Association of TriC/CCT with target proteins during biosynthesis
- TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
- CDK-mediated phosphorylation and removal of Cdc6
- Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
- Cyclin E associated events during G1/S transition
- G1/S-Specific Transcription
- Cyclin D associated events in G1
- p53-Dependent G1 DNA Damage Response
- PTK6 Regulates Cell Cycle
- Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
- RHOBTB3 ATPase cycle
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- Laryngeal cancer
- Gastric cancer
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CCNT2 |
cyclin T2 |
- Formation of RNA Pol II elongation complex
- Formation of HIV elongation complex in the absence of HIV Tat
- HIV elongation arrest and recovery
- Pausing and recovery of HIV elongation
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- RNA Polymerase II Pre-transcription Events
- TP53 Regulates Transcription of DNA Repair Genes
- RNA polymerase II transcribes snRNA genes
- RNA polymerase II transcribes snRNA genes
- RNA Polymerase II Transcription Elongation
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CDC27 |
cell division cycle 27 |
- Inactivation of APC/C via direct inhibition of the APC/C complex
- APC/C:Cdc20 mediated degradation of Cyclin B
- Autodegradation of Cdh1 by Cdh1:APC/C
- APC/C:Cdc20 mediated degradation of Securin
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
- Cdc20:Phospho-APC/C mediated degradation of Cyclin A
- Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
- Regulation of APC/C activators between G1/S and early anaphase
- APC/C:Cdc20 mediated degradation of mitotic proteins
- Phosphorylation of the APC/C
- APC-Cdc20 mediated degradation of Nek2A
- Separation of Sister Chromatids
- Senescence-Associated Secretory Phenotype (SASP)
- CDK-mediated phosphorylation and removal of Cdc6
- Transcriptional Regulation by VENTX
- Aberrant regulation of mitotic exit in cancer due to RB1 defects
- Antigen processing: Ubiquitination & Proteasome degradation
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CDK14 |
cyclin dependent kinase 14 |
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CDK3 |
cyclin dependent kinase 3 |
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CDKN1C |
cyclin dependent kinase inhibitor 1C |
- Cyclin D associated events in G1
- Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
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- Beckwith-Wiedemann syndrome
- Adrenal carcinoma
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CEBPA |
CCAAT enhancer binding protein alpha |
- Transcriptional regulation of white adipocyte differentiation
- Transcriptional regulation of white adipocyte differentiation
- Transcriptional regulation of granulopoiesis
- Transcriptional regulation of granulopoiesis
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- Acute myeloid leukemia (AML)
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CEBPD |
CCAAT enhancer binding protein delta |
- Transcriptional regulation of white adipocyte differentiation
- Interleukin-4 and Interleukin-13 signaling
- HCMV Late Events
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CEBPE |
CCAAT enhancer binding protein epsilon |
- Transcriptional regulation of granulopoiesis
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- Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome
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