|
RBBP6 |
RB binding protein 6, ubiquitin ligase |
- Antigen processing: Ubiquitination & Proteasome degradation
|
|
|
|
RBBP7 |
RB binding protein 7, chromatin remodeling factor |
- PRC2 methylates histones and DNA
- Oxidative Stress Induced Senescence
- HDACs deacetylate histones
- PKMTs methylate histone lysines
- HATs acetylate histones
- RMTs methylate histone arginines
- ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
- Activation of anterior HOX genes in hindbrain development during early embryogenesis
- Deposition of new CENPA-containing nucleosomes at the centromere
- Regulation of TP53 Activity through Acetylation
- RNA Polymerase I Transcription Initiation
- Regulation of PTEN gene transcription
- Regulation of PTEN gene transcription
- Neddylation
- Transcriptional Regulation by E2F6
- HCMV Early Events
- Potential therapeutics for SARS
|
|
|
|
RBBP8 |
RB binding protein 8, endonuclease |
- HDR through Single Strand Annealing (SSA)
- HDR through MMEJ (alt-NHEJ)
- HDR through Homologous Recombination (HRR)
- Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
- Resolution of D-loop Structures through Holliday Junction Intermediates
- Homologous DNA Pairing and Strand Exchange
- Processing of DNA double-strand break ends
- Presynaptic phase of homologous DNA pairing and strand exchange
- Regulation of TP53 Activity through Phosphorylation
- G2/M DNA damage checkpoint
- Transcriptional Regulation by E2F6
- Meiotic recombination
|
|
|
|
RBBP9 |
RB binding protein 9, serine hydrolase |
|
|
|
|
RING1 |
ring finger protein 1 |
- Oxidative Stress Induced Senescence
- SUMOylation of DNA damage response and repair proteins
- SUMOylation of transcription cofactors
- SUMOylation of chromatin organization proteins
- SUMOylation of RNA binding proteins
- SUMOylation of DNA methylation proteins
- RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
- Regulation of PTEN gene transcription
- Regulation of PTEN gene transcription
- Transcriptional Regulation by E2F6
|
|
|
|
RINT1 |
RAD50 interactor 1 |
- COPI-dependent Golgi-to-ER retrograde traffic
|
|
|
|
RNF123 |
ring finger protein 123 |
- Ub-specific processing proteases
- Antigen processing: Ubiquitination & Proteasome degradation
|
|
|
|
RNF40 |
ring finger protein 40 |
- E3 ubiquitin ligases ubiquitinate target proteins
|
|
|
|
RUNX2 |
RUNX family transcription factor 2 |
|
|
|
|
SHC1 |
SHC adaptor protein 1 |
- Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
- SHC1 events in ERBB2 signaling
- SHC1 events in ERBB2 signaling
- SHC1 events in ERBB4 signaling
- Signalling to RAS
- Signalling to RAS
- SHC1 events in EGFR signaling
- Tie2 Signaling
- Integrin signaling
- XBP1(S) activates chaperone genes
- Interleukin-3, Interleukin-5 and GM-CSF signaling
- Constitutive Signaling by EGFRvIII
- RAF/MAP kinase cascade
- Signal attenuation
- Insulin receptor signalling cascade
- Insulin receptor signalling cascade
- RET signaling
- Interleukin-15 signaling
- Interleukin-15 signaling
- Interleukin-2 signaling
- Erythropoietin activates RAS
- Erythropoietin activates RAS
- Interleukin receptor SHC signaling
- Constitutive Signaling by Overexpressed ERBB2
- Signaling by ERBB2 KD Mutants
- Signaling by ERBB2 ECD mutants
- Signaling by ERBB2 TMD/JMD mutants
|
|
|
|
SKP2 |
S-phase kinase associated protein 2 |
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
- SCF(Skp2)-mediated degradation of p27/p21
- Ub-specific processing proteases
- Orc1 removal from chromatin
- Cyclin D associated events in G1
- Regulation of RUNX2 expression and activity
- Neddylation
- Aberrant regulation of mitotic exit in cancer due to RB1 defects
- Antigen processing: Ubiquitination & Proteasome degradation
|
|
|
|
SMARCA4 |
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 |
- Interleukin-7 signaling
- Formation of the beta-catenin:TCF transactivating complex
- RMTs methylate histone arginines
- Chromatin modifying enzymes
- RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
- EGR2 and SOX10-mediated initiation of Schwann cell myelination
- EGR2 and SOX10-mediated initiation of Schwann cell myelination
|
|
|
|
SMARCB1 |
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 |
- RMTs methylate histone arginines
- RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
|
|
|
|
SMYD2 |
SET and MYND domain containing 2 |
- PKMTs methylate histone lysines
- Regulation of TP53 Activity through Methylation
|
|
|
|
SNAPC1 |
small nuclear RNA activating complex polypeptide 1 |
- RNA polymerase II transcribes snRNA genes
- RNA polymerase II transcribes snRNA genes
- RNA Polymerase III Abortive And Retractive Initiation
- RNA Polymerase III Transcription Initiation From Type 3 Promoter
- RNA Polymerase III Transcription Initiation From Type 3 Promoter
|
|
|
|
SNAPC3 |
small nuclear RNA activating complex polypeptide 3 |
- RNA polymerase II transcribes snRNA genes
- RNA polymerase II transcribes snRNA genes
- RNA Polymerase III Abortive And Retractive Initiation
- RNA Polymerase III Transcription Initiation From Type 3 Promoter
- RNA Polymerase III Transcription Initiation From Type 3 Promoter
|
|
|
|
SNW1 |
SNW domain containing 1 |
- Pre-NOTCH Transcription and Translation
- Pre-NOTCH Transcription and Translation
- Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
- NOTCH1 Intracellular Domain Regulates Transcription
- NOTCH1 Intracellular Domain Regulates Transcription
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- Notch-HLH transcription pathway
- mRNA Splicing - Major Pathway
- RUNX3 regulates NOTCH signaling
- RUNX3 regulates NOTCH signaling
- NOTCH3 Intracellular Domain Regulates Transcription
- NOTCH3 Intracellular Domain Regulates Transcription
- NOTCH4 Intracellular Domain Regulates Transcription
|
|
|
|
SP1 |
Sp1 transcription factor |
- PPARA activates gene expression
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- Activation of gene expression by SREBF (SREBP)
- Oncogene Induced Senescence
- RNA polymerase II transcribes snRNA genes
- RNA polymerase II transcribes snRNA genes
- Estrogen-dependent gene expression
|
|
|
|
SP3 |
Sp3 transcription factor |
- SUMOylation of transcription factors
|
|
|
|
SPI1 |
Spi-1 proto-oncogene |
- RUNX1 regulates transcription of genes involved in differentiation of HSCs
- Transcriptional regulation of granulopoiesis
- Transcriptional regulation of granulopoiesis
|
|
- Acute myeloid leukemia (AML)
|