Search Results for: RB1

199 interactions involving RB1 - RB transcriptional corepressor 1 found:

Sort by: Symbol Number of Pathways Number of Drugs Number of Diseases
Novel Interactant Symbol Name
Associated Pathways
Binding Drugs
Associated Diseases
CEBPB CCAAT enhancer binding protein beta
  • Senescence-Associated Secretory Phenotype (SASP)
  • Senescence-Associated Secretory Phenotype (SASP)
  • ATF4 activates genes in response to endoplasmic reticulum stress
  • Transcriptional regulation of white adipocyte differentiation
  • Transcriptional regulation of white adipocyte differentiation
  • Transcriptional Regulation by VENTX
  • Transcriptional regulation of granulopoiesis
  • Response of EIF2AK4 (GCN2) to amino acid deficiency
  • Response of EIF2AK4 (GCN2) to amino acid deficiency
  • Response of EIF2AK1 (HRI) to heme deficiency
  • Response of EIF2AK1 (HRI) to heme deficiency
  • Quercetin
CEBPD CCAAT enhancer binding protein delta
  • Transcriptional regulation of white adipocyte differentiation
  • Interleukin-4 and Interleukin-13 signaling
  • HCMV Late Events
CHEK1 checkpoint kinase 1
  • Signaling by SCF-KIT
  • Activation of ATR in response to replication stress
  • Processing of DNA double-strand break ends
  • Presynaptic phase of homologous DNA pairing and strand exchange
  • TP53 Regulates Transcription of DNA Repair Genes
  • Regulation of TP53 Activity through Phosphorylation
  • G2/M DNA damage checkpoint
  • Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
  • Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
  • Transcriptional Regulation by E2F6
  • XL844
  • Enzastaurin
  • CHIR-124
  • N-{5-[4-(4-METHYLPIPERAZIN-1-YL)PHENYL]-1H-PYRROLO[2,3-B]PYRIDIN-3-YL}NICOTINAMIDE
  • 3-(5-{[4-(AMINOMETHYL)PIPERIDIN-1-YL]METHYL}-1H-INDOL-2-YL)QUINOLIN-2(1H)-ONE
  • 2,2'-{[9-(HYDROXYIMINO)-9H-FLUORENE-2,7-DIYL]BIS(OXY)}DIACETIC ACID
  • (2S)-1-AMINO-3-[(5-NITROQUINOLIN-8-YL)AMINO]PROPAN-2-OL
  • 2-(cyclohexylamino)benzoic acid
  • 3-(5-{[4-(AMINOMETHYL)PIPERIDIN-1-YL]METHYL}-1H-INDOL-2-YL)-1H-INDAZOLE-6-CARBONITRILE
  • (3Z)-6-(4-HYDROXY-3-METHOXYPHENYL)-3-(1H-PYRROL-2-YLMETHYLENE)-1,3-DIHYDRO-2H-INDOL-2-ONE
  • 5-ETHYL-3-METHYL-1,5-DIHYDRO-4H-PYRAZOLO[4,3-C]QUINOLIN-4-ONE
  • (5-{3-[5-(PIPERIDIN-1-YLMETHYL)-1H-INDOL-2-YL]-1H-INDAZOL-6-YL}-2H-1,2,3-TRIAZOL-4-YL)METHANOL
  • 1-(5-CHLORO-2-METHOXYPHENYL)-3-{6-[2-(DIMETHYLAMINO)-1-METHYLETHOXY]PYRAZIN-2-YL}UREA
  • (3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLATE
  • 18-CHLORO-11,12,13,14-TETRAHYDRO-1H,10H-8,4-(AZENO)-9,15,1,3,6-BENZODIOXATRIAZACYCLOHEPTADECIN-2-ONE
  • 1-(5-CHLORO-2,4-DIMETHOXYPHENYL)-3-(5-CYANOPYRAZIN-2-YL)UREA
  • 4-(6-{[(4-METHYLCYCLOHEXYL)AMINO]METHYL}-1,4-DIHYDROINDENO[1,2-C]PYRAZOL-3-YL)BENZOIC ACID
  • 4-[3-(1H-BENZIMIDAZOL-2-YL)-1H-INDAZOL-6-YL]-2-METHOXYPHENOL
  • (2R)-1-[(5,6-DIPHENYL-7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)AMINO]PROPAN-2-OL
  • (2R)-3-{[(4Z)-5,6-DIPHENYL-6,7-DIHYDRO-4H-PYRROLO[2,3-D]PYRIMIDIN-4-YLIDENE]AMINO}PROPANE-1,2-DIOL
  • N-(5,6-DIPHENYLFURO[2,3-D]PYRIMIDIN-4-YL)GLYCINE
  • (5,6-DIPHENYL-FURO[2,3-D]PYRIMIDIN-4-YLAMINO)-ACETIC
  • 3-AMINO-3-BENZYL-[4.3.0]BICYCLO-1,6-DIAZANONAN-2-ONE
  • 3-(1H-BENZIMIDAZOL-2-YL)-1H-INDAZOLE
  • 2-[5,6-BIS-(4-METHOXY-PHENYL)-FURO[2,3-D]PYRIMIDIN-4-YLAMINO]-ETHANOL
  • 2-[(5,6-DIPHENYLFURO[2,3-D]PYRIMIDIN-4-YL)AMINO]ETHANOL
  • REL-(9R,12S)-9,10,11,12-TETRAHYDRO-9,12-EPOXY-1H-DIINDOLO[1,2,3-FG:3',2',1'-KL]PYRROLO[3,4-I][1,6]BENZODIAZOCINE-1,3(2H)-DIONE
  • 1-[(2S)-4-(5-phenyl-1H-pyrazolo[3,4-b]pyridin-4-yl)morpholin-2-yl]methanamine
  • N-(4-OXO-5,6,7,8-TETRAHYDRO-4H-[1,3]THIAZOLO[5,4-C]AZEPIN-2-YL)ACETAMIDE
  • 5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDIN-4(3H)-ONE
  • [4-amino-2-(tert-butylamino)-1,3-thiazol-5-yl](phenyl)methanone
  • 2-(methylsulfanyl)-5-(thiophen-2-ylmethyl)-1H-imidazol-4-ol
  • 6-MORPHOLIN-4-YL-9H-PURINE
  • 1-[(2S)-4-(5-BROMO-1H-PYRAZOLO[3,4-B]PYRIDIN-4-YL)MORPHOLIN-2-YL]METHANAMINE
  • Fostamatinib
CHN2 chimerin 2
  • Rho GTPase cycle
CLNK cytokine dependent hematopoietic cell linker
CORO2A coronin 2A
CREG1 cellular repressor of E1A stimulated genes 1
  • Neutrophil degranulation
CTBP1 C-terminal binding protein 1
  • Deactivation of the beta-catenin transactivating complex
  • SUMOylation of transcription cofactors
  • Repression of WNT target genes
  • Signaling by TCF7L2 mutants
  • Formic acid
CTSV cathepsin V
  • Endosomal/Vacuolar pathway
  • Degradation of the extracellular matrix
  • Activation of Matrix Metalloproteinases
  • Trafficking and processing of endosomal TLR
  • Assembly of collagen fibrils and other multimeric structures
  • MHC class II antigen presentation
  • RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
  • 3-amino-5-phenylpentane
  • 4-Methylpiperazin-1-Yl Carbonyl Group
CUX1 cut like homeobox 1
  • Signaling by cytosolic FGFR1 fusion mutants
  • Signaling by FGFR1 in disease
  • Intra-Golgi traffic
DGKZ diacylglycerol kinase zeta
  • Effects of PIP2 hydrolysis
  • alpha-Tocopherol succinate
DNMT1 DNA methyltransferase 1
  • PRC2 methylates histones and DNA
  • NoRC negatively regulates rRNA expression
  • SUMOylation of DNA methylation proteins
  • DNA methylation
  • Procaine
  • Azacitidine
  • Procainamide
  • Flucytosine
  • Decitabine
  • Palifosfamide
  • Epigallocatechin gallate
DVL1 dishevelled segment polarity protein 1
  • TCF dependent signaling in response to WNT
  • WNT mediated activation of DVL
  • PCP/CE pathway
  • PCP/CE pathway
  • Degradation of DVL
  • Disassembly of the destruction complex and recruitment of AXIN to the membrane
  • Disassembly of the destruction complex and recruitment of AXIN to the membrane
  • Negative regulation of TCF-dependent signaling by DVL-interacting proteins
  • RHO GTPases Activate Formins
  • WNT5:FZD7-mediated leishmania damping
  • WNT5:FZD7-mediated leishmania damping
DYRK1A dual specificity tyrosine phosphorylation regulated kinase 1A
  • G0 and Early G1
  • N-(5-{[(2S)-4-amino-2-(3-chlorophenyl)butanoyl]amino}-1H-indazol-3-yl)benzamide
  • Fostamatinib
E2F1 E2F transcription factor 1
  • Activation of NOXA and translocation to mitochondria
  • Inhibition of replication initiation of damaged DNA by RB1/E2F1
  • Transcription of E2F targets under negative control by DREAM complex
  • Transcription of E2F targets under negative control by DREAM complex
  • Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
  • Activation of PUMA and translocation to mitochondria
  • Pre-NOTCH Transcription and Translation
  • Pre-NOTCH Transcription and Translation
  • Oxidative Stress Induced Senescence
  • Oncogene Induced Senescence
  • TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
  • CDC6 association with the ORC:origin complex
  • G2 Phase
  • Cyclin E associated events during G1/S transition
  • G1/S-Specific Transcription
  • G1/S-Specific Transcription
  • Cyclin D associated events in G1
  • Cyclin A:Cdk2-associated events at S phase entry
  • Transcriptional Regulation by E2F6
  • Transcriptional regulation of granulopoiesis
  • Transcriptional regulation of granulopoiesis
  • Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
E2F2 E2F transcription factor 2
  • Oxidative Stress Induced Senescence
  • Oncogene Induced Senescence
  • CDC6 association with the ORC:origin complex
  • Cyclin D associated events in G1
  • Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
E2F3 E2F transcription factor 3
  • Pre-NOTCH Transcription and Translation
  • Pre-NOTCH Transcription and Translation
  • Oxidative Stress Induced Senescence
  • Oncogene Induced Senescence
  • CDC6 association with the ORC:origin complex
  • G2 Phase
  • Cyclin D associated events in G1
  • Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
E2F4 E2F transcription factor 4
  • Transcription of E2F targets under negative control by DREAM complex
  • Transcription of E2F targets under negative control by DREAM complex
  • Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
  • G0 and Early G1
  • SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
  • TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
  • Cyclin E associated events during G1/S transition
  • G1/S-Specific Transcription
  • G1/S-Specific Transcription
  • Cyclin D associated events in G1
  • Cyclin A:Cdk2-associated events at S phase entry
E4F1 E4F transcription factor 1
EID1 EP300 interacting inhibitor of differentiation 1

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