RASSF1 - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Associated Diseases Hide
MST1	macrophage stimulating 1	Signaling by MST1
NF2	neurofibromin 2	Regulation of actin dynamics for phagocytic cup formation RHO GTPases activate PAKs	Malignant pleural mesothelioma Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
NUDT10	nudix hydrolase 10	Synthesis of pyrophosphates in the cytosol
RASSF5	Ras association domain family member 5
RHOU	ras homolog family member U	Rho GTPase cycle Interleukin-4 and Interleukin-13 signaling
SAV1	salvador family WW domain containing protein 1	Signaling by Hippo
SMARCA4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Interleukin-7 signaling Formation of the beta-catenin:TCF transactivating complex RMTs methylate histone arginines Chromatin modifying enzymes RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known EGR2 and SOX10-mediated initiation of Schwann cell myelination EGR2 and SOX10-mediated initiation of Schwann cell myelination
STK11	serine/threonine kinase 11	AMPK inhibits chREBP transcriptional activation activity Energy dependent regulation of mTOR by LKB1-AMPK Regulation of TP53 Activity through Phosphorylation FOXO-mediated transcription of cell death genes	Peutz-Jeghers syndrome Pancreatic cancer
STK4	serine/threonine kinase 4	Signaling by Hippo
SUV39H1	suppressor of variegation 3-9 homolog 1	PKMTs methylate histone lysines SIRT1 negatively regulates rRNA expression
SUV39H2	suppressor of variegation 3-9 homolog 2	PKMTs methylate histone lysines
TEAD2	TEA domain transcription factor 2	YAP1- and WWTR1 (TAZ)-stimulated gene expression RUNX3 regulates YAP1-mediated transcription
TNFRSF10A	TNF receptor superfamily member 10a	Caspase activation via Death Receptors in the presence of ligand Cell surface interactions at the vascular wall Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TP53 Regulates Transcription of Death Receptors and Ligands Dimerization of procaspase-8 TRAIL signaling
TSC1	TSC complex subunit 1	Macroautophagy Inhibition of TSC complex formation by PKB Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes TBC/RABGAPs	Lymphangioleiomyomatosis (LAM) Tuberous sclerosis complex (TSC); Bourneville-Pringle disease
XPA	XPA, DNA damage recognition and repair factor	Formation of Incision Complex in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Dual incision in TC-NER	Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome

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