PIK3CA - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
SGK1	serum/glucocorticoid regulated kinase 1	Stimuli-sensing channels Regulation of TP53 Degradation Transcriptional Regulation by MECP2 NGF-stimulated transcription	Flavin mononucleotide [4-(5-naphthalen-2-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl]acetic acid 4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid
STK11	serine/threonine kinase 11	AMPK inhibits chREBP transcriptional activation activity Energy dependent regulation of mTOR by LKB1-AMPK Regulation of TP53 Activity through Phosphorylation FOXO-mediated transcription of cell death genes		Peutz-Jeghers syndrome Pancreatic cancer
APLP2	amyloid beta precursor like protein 2	Platelet degranulation Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
CCND2	cyclin D2	Cyclin D associated events in G1 Regulation of RUNX1 Expression and Activity Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)		Testicular cancer
GABRB1	gamma-aminobutyric acid type A receptor subunit beta1	Signaling by ERBB4 GABA receptor activation GABA receptor activation	Lorazepam Ethchlorvynol Enflurane Temazepam Butabarbital Butalbital Phenytoin Etomidate Talbutal Pentobarbital Clobazam Meprobamate Eszopiclone Alprazolam Lindane Metharbital Chlordiazepoxide Amoxapine Adinazolam Lamotrigine Medroxyprogesterone acetate Clorazepic acid Acamprosate Midazolam Flurazepam Isoflurane Primidone Halazepam Propofol Diazepam Oxazepam Triazolam Ethanol Methoxyflurane Memantine Clonazepam Methyprylon Halothane Desflurane Flumazenil Estazolam Sevoflurane Glutethimide gamma-Hydroxybutyric acid Camazepam Delorazepam Flunitrazepam Ethyl loflazepate Cloxazolam Bromazepam Clotiazepam Fludiazepam Ketazolam Prazepam Quazepam Cinolazepam Nitrazepam Prasterone Taurine Brotizolam Stiripentol Etizolam Thiocolchicoside Brexanolone Apalutamide Remimazolam Benzodiazepine Pinazepam Medazepam Loprazolam Doxefazepam Lormetazepam Nordazepam Oxazepam acetate Cinazepam Bentazepam Mexazolam
RASGRP3	RAS guanyl releasing protein 3	Activation of RAS in B cells Activation of RAS in B cells RAF/MAP kinase cascade
CSF1R	colony stimulating factor 1 receptor	Other interleukin signaling Transcriptional Regulation by VENTX	Imatinib Sunitinib ABT-869 5-CYANO-FURAN-2-CARBOXYLIC ACID [5-HYDROXYMETHYL-2-(4-METHYL-PIPERIDIN-1-YL)-PHENYL]-AMIDE 6-CHLORO-3-(3-METHYLISOXAZOL-5-YL)-4-PHENYLQUINOLIN-2(1H)-ONE Fostamatinib Erdafitinib Pexidartinib	Choriocarcinoma
FANCC	FA complementation group C	Fanconi Anemia Pathway TP53 Regulates Transcription of DNA Repair Genes		Fanconi anemia
GALNT12	polypeptide N-acetylgalactosaminyltransferase 12	Defective GALNT12 causes colorectal cancer 1 (CRCS1) O-linked glycosylation of mucins
MRAS	muscle RAS oncogene homolog	RAF activation Signaling by MRAS-complex mutants
PDK1	pyruvate dehydrogenase kinase 1	Regulation of pyruvate dehydrogenase (PDH) complex Signaling by Retinoic Acid	4-[(3-CHLORO-4-{[(2R)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPANOYL]AMINO}PHENYL)SULFONYL]-N,N-DIMETHYLBENZAMIDE Dichloroacetic acid
SNX9	sorting nexin 9	Golgi Associated Vesicle Biogenesis Clathrin-mediated endocytosis
TNFSF13	TNF superfamily member 13	HuR (ELAVL1) binds and stabilizes mRNA TNFs bind their physiological receptors
UFD1	ubiquitin recognition factor in ER associated degradation 1	Translesion Synthesis by POLH Ub-specific processing proteases
ADAP1	ArfGAP with dual PH domains 1	Nuclear signaling by ERBB4
AMBP	alpha-1-microglobulin/bikunin precursor	Scavenging of heme from plasma
APPL1	adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1	Caspase activation via Dependence Receptors in the absence of ligand
CYTH2	cytohesin 2	Intra-Golgi traffic	Inositol 1,3,4,5-Tetrakisphosphate Formic acid 1D-myo-inositol 1,4,5-trisphosphate S,S-(2-Hydroxyethyl)Thiocysteine Brefeldin A
CYTH3	cytohesin 3	Intra-Golgi traffic	Inositol 1,3,4,5-Tetrakisphosphate Inositol-(1,3,4,5,6)-Pentakisphosphate
DNAJB6	DnaJ heat shock protein family (Hsp40) member B6	Regulation of HSF1-mediated heat shock response

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