Search Results for: PIK3CA

78 interactions involving PIK3CA - phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha found:

Sort by: Symbol Number of Pathways Number of Drugs Number of Diseases
Novel Interactant Symbol Name
Associated Pathways
Binding Drugs
Associated Diseases
AMBP alpha-1-microglobulin/bikunin precursor
  • Scavenging of heme from plasma
APPL1 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1
  • Caspase activation via Dependence Receptors in the absence of ligand
ATP5IF1 ATP synthase inhibitory factor subunit 1
ATR ATR serine/threonine kinase
  • Meiotic synapsis
  • Activation of ATR in response to replication stress
  • Regulation of HSF1-mediated heat shock response
  • HDR through Single Strand Annealing (SSA)
  • Processing of DNA double-strand break ends
  • Presynaptic phase of homologous DNA pairing and strand exchange
  • Fanconi Anemia Pathway
  • TP53 Regulates Transcription of DNA Repair Genes
  • Regulation of TP53 Activity through Phosphorylation
  • G2/M DNA damage checkpoint
  • Alveolar rhabdomyosarcoma
  • Seckel syndrome
BEX1 brain expressed X-linked 1
BEX2 brain expressed X-linked 2
CCND2 cyclin D2
  • Cyclin D associated events in G1
  • Regulation of RUNX1 Expression and Activity
  • Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
  • Testicular cancer
DNAJB6 DnaJ heat shock protein family (Hsp40) member B6
  • Regulation of HSF1-mediated heat shock response
FANCC FA complementation group C
  • Fanconi Anemia Pathway
  • TP53 Regulates Transcription of DNA Repair Genes
  • Fanconi anemia
FASLG Fas ligand
  • Caspase activation via Death Receptors in the presence of ligand
  • Regulation by c-FLIP
  • RIPK1-mediated regulated necrosis
  • CASP8 activity is inhibited
  • Interleukin-4 and Interleukin-13 signaling
  • Dimerization of procaspase-8
  • FasL/ CD95L signaling
  • Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
  • FOXO-mediated transcription of cell death genes
  • TNFs bind their physiological receptors
  • Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases: CD95 (Fas) defect, ALPS type 1a; CD95L (Fas ligand) defect, ALPS type 1b; Caspase 10 defect, ALPS type 2a; Caspase 8 defext, ALPS type 2b; Activaing N-Ras defect, N-Ras ALPS
FBP2 fructose-bisphosphatase 2
  • Gluconeogenesis
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
  • Defective GALNT12 causes colorectal cancer 1 (CRCS1)
  • O-linked glycosylation of mucins
GLIS2 GLIS family zinc finger 2
  • Nephronophthisis-medullary cystic kidney disease, including; Nephronophthisis (NPH) ; Nephronophthisis-like nephropathy 1; Medullary cystic kidney disease 1; Medullary cystic kidney disease 2 (MSKD2)
GNAQ G protein subunit alpha q
  • Acetylcholine regulates insulin secretion
  • Acetylcholine regulates insulin secretion
  • G alpha (q) signalling events
  • G alpha (q) signalling events
  • ADP signalling through P2Y purinoceptor 1
  • ADP signalling through P2Y purinoceptor 1
  • Thromboxane signalling through TP receptor
  • Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
  • Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
  • Thrombin signalling through proteinase activated receptors (PARs)
IL24 interleukin 24
  • Interleukin-20 family signaling
IRS2 insulin receptor substrate 2
  • PI3K Cascade
  • IRS-mediated signalling
  • SOS-mediated signalling
  • SOS-mediated signalling
  • PIP3 activates AKT signaling
  • Interleukin-7 signaling
  • PI3K/AKT activation
  • PI3K/AKT activation
  • Constitutive Signaling by Aberrant PI3K in Cancer
  • IRS-related events triggered by IGF1R
  • Signaling by Leptin
  • RAF/MAP kinase cascade
  • PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
  • IRS activation
  • Signal attenuation
  • RET signaling
  • Signaling by Erythropoietin
  • Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
  • Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
  • Erythropoietin activates Phospholipase C gamma (PLCG)
  • Erythropoietin activates STAT5
  • Erythropoietin activates RAS
  • Erythropoietin activates RAS
  • Growth hormone receptor signaling
IRS4 insulin receptor substrate 4
  • IRS-related events triggered by IGF1R
MRAS muscle RAS oncogene homolog
  • RAF activation
  • Signaling by MRAS-complex mutants
NEDD4L NEDD4 like E3 ubiquitin protein ligase
  • Budding and maturation of HIV virion
  • Downregulation of TGF-beta receptor signaling
  • Downregulation of SMAD2/3:SMAD4 transcriptional activity
  • Stimuli-sensing channels
  • Antigen processing: Ubiquitination & Proteasome degradation
NEDD9 neural precursor cell expressed, developmentally down-regulated 9

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