MAPK8 - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
JUND	JunD proto-oncogene, AP-1 transcription factor subunit	Estrogen-dependent gene expression NGF-stimulated transcription NGF-stimulated transcription
NFE2	nuclear factor, erythroid 2	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Factors involved in megakaryocyte development and platelet production Factors involved in megakaryocyte development and platelet production
NR4A1	nuclear receptor subfamily 4 group A member 1	AKT phosphorylates targets in the nucleus Nuclear Receptor transcription pathway Constitutive Signaling by AKT1 E17K in Cancer
SPI1	Spi-1 proto-oncogene	RUNX1 regulates transcription of genes involved in differentiation of HSCs Transcriptional regulation of granulopoiesis Transcriptional regulation of granulopoiesis		Acute myeloid leukemia (AML)
TNFSF11	TNF superfamily member 11	TNFR2 non-canonical NF-kB pathway TNFs bind their physiological receptors TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	Lenalidomide AMGN-0007 Denosumab Thiocolchicoside	Osteopetrosis, including: Osteopetrosis, severe neonatal or infantile forms; Osteopetrosis, intermediate forms; Osteopetrosis with renal tubular acidosis; Osteopetrosis, late-onset form type 1; Osteopetrosis, late-onset form type 2; Osteopetrosis, osteoclast poor
WWOX	WW domain containing oxidoreductase	Nuclear signaling by ERBB4 Negative regulation of activity of TFAP2 (AP-2) family transcription factors Activation of the TFAP2 (AP-2) family of transcription factors
AIMP1	aminoacyl tRNA synthetase complex interacting multifunctional protein 1	Selenoamino acid metabolism Cytosolic tRNA aminoacylation		Hypomyelinating leukodystrophy (HLD); Pelizaeus-Merzbacher disease (PMD)
BMF	Bcl2 modifying factor	BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Activation of BMF and translocation to mitochondria
CAMP	cathelicidin antimicrobial peptide	Neutrophil degranulation Antimicrobial peptides	Selenocysteine
DUSP1	dual specificity phosphatase 1	RAF-independent MAPK1/3 activation Negative regulation of MAPK pathway
GARS1	glycyl-tRNA synthetase 1	Cytosolic tRNA aminoacylation Mitochondrial tRNA aminoacylation	Glycine	Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy Distal hereditary motor neuropathies (dHMN)
GUCY1A1	guanylate cyclase 1 soluble subunit alpha 1	Nitric oxide stimulates guanylate cyclase Smooth Muscle Contraction
KRT8	keratin 8	Keratinization Formation of the cornified envelope	Tenecteplase Lanoteplase Copper
RAD18	RAD18 E3 ubiquitin protein ligase	Recognition of DNA damage by PCNA-containing replication complex E3 ubiquitin ligases ubiquitinate target proteins
RET	ret proto-oncogene	RAF/MAP kinase cascade RET signaling	Sorafenib 1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine Vandetanib Cabozantinib Regorafenib Ponatinib Lenvatinib Fostamatinib Amuvatinib Selpercatinib Pralsetinib	Hirschsprung disease (HD) Renal agenesis and Renal adysplasia Thyroid cancer Congenital central hypoventilation syndrome (CCHS)
SPAG9	sperm associated antigen 9	Myogenesis Myogenesis
BMPR2	bone morphogenetic protein receptor type 2	Signaling by BMP	Dibotermin alfa Fostamatinib
CCDC88C	coiled-coil domain containing 88C	Negative regulation of TCF-dependent signaling by DVL-interacting proteins
EEF2K	eukaryotic elongation factor 2 kinase	mTORC1-mediated signalling
ELP1	elongator acetyltransferase complex subunit 1	HATs acetylate histones

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