KRT5 and ALOX12

Data Source:
BioGRID (two hybrid, affinity chromatography technology)
HPRD (in vivo)

		KRT5	ALOX12
Description		keratin 5	arachidonate 12-lipoxygenase, 12S type
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Intermediate Filament Membrane Keratin Filament Extracellular Exosome	Cytoplasm Cytosol Plasma Membrane Membrane Sarcolemma Extracellular Exosome
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Scaffold Protein Binding	Arachidonate 12(S)-lipoxygenase Activity Iron Ion Binding Protein Binding Linoleate 13S-lipoxygenase Activity Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Hepoxilin-epoxide Hydrolase Activity Arachidonate 15-lipoxygenase Activity
	Biological Process	Cytoskeleton Organization Epidermis Development Keratinization Hemidesmosome Assembly Cornification	Lipid Metabolic Process Aging Positive Regulation Of Gene Expression Negative Regulation Of Muscle Cell Apoptotic Process Arachidonic Acid Metabolic Process Lipoxygenase Pathway Fatty Acid Oxidation Unsaturated Fatty Acid Metabolic Process Lipid Oxidation Superoxide Anion Generation Long-chain Fatty Acid Biosynthetic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Linoleic Acid Metabolic Process Positive Regulation Of Smooth Muscle Cell Proliferation Hepoxilin Metabolic Process Hepoxilin Biosynthetic Process Positive Regulation Of Mitochondrial Depolarization Establishment Of Skin Barrier Cellular Response To Lipid Negative Regulation Of Platelet Aggregation Leukotriene A4 Metabolic Process Positive Regulation Of Endothelial Tube Morphogenesis Lipoxin Biosynthetic Process Lipoxin A4 Biosynthetic Process Lipoxin B4 Biosynthetic Process
Pathways		Type I hemidesmosome assembly Keratinization Formation of the cornified envelope	Synthesis of Hepoxilins (HX) and Trioxilins (TrX) Synthesis of Lipoxins (LX) Synthesis of 12-eicosatetraenoic acid derivatives Biosynthesis of DHA-derived SPMs Biosynthesis of DPAn-6 SPMs Biosynthesis of DPAn-3-derived maresins
Drugs		Zinc Zinc acetate
Diseases		Dowling-Degos disease Epidermolysis bullosa simplex, including: Epidermolysis bullosa simplex, Dowling-Meara type (EBS-DM); Epidermolysis bullosa simplex, Koebner type (EBS-K); Epidermolysis bullosa simplex, Weber-Cockayne type (EBS-WC); Epidermolysis bullosa simplex with mottled pigmentation (EBS-MP); Epidermolysis bullosa simplex with migratory circinate erythema; Epidermolysis bullosa simplex, recessive; Epidermolysis bullosa, lethal acantholytic
GWAS		Basal cell carcinoma ( 31174203 24403052 25855136 27539887) Cutaneous squamous cell carcinoma ( 32041948) Keratinocyte cancer (MTAG) ( 31174203) Non-melanoma skin cancer ( 29739929) Squamous cell carcinoma ( 31174203)	Blood metabolite levels ( 24816252) Mean platelet volume ( 32888494)
Interacting Genes		25 interacting genes: ALOX12 ALOX12B APC DSP DST EVPL INCA1 KIFC3 KRT1 KRT14 KRT15 KRT16 KRT18 KRT19 KRT24 KRT25 KRT27 KRT28 KRT31 KRT35 KRT38 KRT40 PKP2 TCHP UBE3A	7 interacting genes: ITGB4 KAT5 KRT5 KRT85 LMNA PLA2G2A TRIB1
Entrez ID		3852	239
HPRD ID		01010	01066
Ensembl ID		ENSG00000186081	ENSG00000108839
Uniprot IDs		P13647	P18054
PDB IDs		3TNU 6JFV	2ABU 3D3L
Enriched GO Terms of Interacting Partners?
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