KRT5 and GPD1

Data Source:
BioGRID (affinity chromatography technology)

		KRT5	GPD1
Description		keratin 5	glycerol-3-phosphate dehydrogenase 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Intermediate Filament Membrane Keratin Filament Extracellular Exosome	Cytosol Glycerol-3-phosphate Dehydrogenase Complex Extracellular Exosome
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Scaffold Protein Binding	Glycerol-3-phosphate Dehydrogenase [NAD+] Activity Glycerol-3-phosphate Dehydrogenase (quinone) Activity Protein Binding Protein Homodimerization Activity NAD Binding
	Biological Process	Cytoskeleton Organization Epidermis Development Keratinization Hemidesmosome Assembly Cornification	Glycerol-3-phosphate Metabolic Process Gluconeogenesis NADH Oxidation Glycerophosphate Shuttle Phosphatidic Acid Biosynthetic Process Positive Regulation Of Glycolytic Process Glycerol-3-phosphate Catabolic Process Cellular Response To CAMP Cellular Response To Tumor Necrosis Factor
Pathways		Type I hemidesmosome assembly Keratinization Formation of the cornified envelope	Synthesis of PA
Drugs		Zinc Zinc acetate	NADH Metformin
Diseases		Dowling-Degos disease Epidermolysis bullosa simplex, including: Epidermolysis bullosa simplex, Dowling-Meara type (EBS-DM); Epidermolysis bullosa simplex, Koebner type (EBS-K); Epidermolysis bullosa simplex, Weber-Cockayne type (EBS-WC); Epidermolysis bullosa simplex with mottled pigmentation (EBS-MP); Epidermolysis bullosa simplex with migratory circinate erythema; Epidermolysis bullosa simplex, recessive; Epidermolysis bullosa, lethal acantholytic
GWAS		Basal cell carcinoma ( 31174203 24403052 25855136 27539887) Cutaneous squamous cell carcinoma ( 32041948) Keratinocyte cancer (MTAG) ( 31174203) Non-melanoma skin cancer ( 29739929) Squamous cell carcinoma ( 31174203)	Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body size at age 10 ( 32376654)
Interacting Genes		25 interacting genes: ALOX12 ALOX12B APC DSP DST EVPL INCA1 KIFC3 KRT1 KRT14 KRT15 KRT16 KRT18 KRT19 KRT24 KRT25 KRT27 KRT28 KRT31 KRT35 KRT38 KRT40 PKP2 TCHP UBE3A	7 interacting genes: FAM25A FAM25C FAM25G GK MDH1 POMP PTN
Entrez ID		3852	2819
HPRD ID		01010	00714
Ensembl ID		ENSG00000186081	ENSG00000167588
Uniprot IDs		P13647	A0A024R138 P21695
PDB IDs		3TNU 6JFV	1WPQ 1X0V 1X0X 6E8Y 6E8Z 6E90 6PYP
Enriched GO Terms of Interacting Partners?
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