KEAP1 - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
ICAM1	intercellular adhesion molecule 1	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling	Natalizumab Hyaluronic acid Nafamostat	Allograft rejection
CLU	clusterin	Platelet degranulation Terminal pathway of complement Antimicrobial peptides Regulation of Complement cascade	Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
PALB2	partner and localizer of BRCA2	HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange		Fanconi anemia
PDCD6IP	programmed cell death 6 interacting protein	Budding and maturation of HIV virion Uptake and function of anthrax toxins RIPK1-mediated regulated necrosis Regulation of necroptotic cell death
EAF1	ELL associated factor 1	Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation
IRF1	interferon regulatory factor 1	Interferon gamma signaling Interferon alpha/beta signaling Factors involved in megakaryocyte development and platelet production
LSM3	LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated	mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease mRNA Splicing - Major Pathway
USP15	ubiquitin specific peptidase 15	Downregulation of TGF-beta receptor signaling UCH proteinases Ub-specific processing proteases
CTTN	cortactin	RHO GTPases activate PAKs Clathrin-mediated endocytosis
KLHL2	kelch like family member 2	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
KLHL3	kelch like family member 3	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
SMARCD1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1	RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
AK4	adenylate kinase 4	Interconversion of nucleotide di- and triphosphates
GLRX5	glutaredoxin 5	Mitochondrial iron-sulfur cluster biogenesis		Erythropoietic porphyria (EP), including: Erythropoietic protoporphyria (EPP); Congenital erythropoietic porphyria (CEP); Gunther Disease; X-linked erythropoietic protoporphyria (XLEPP) Sideroblastic anemia, including: Pyridoxine-refractory autosomal recessive sideroblastic anemia (PRARSA); X-linked sideroblastic anemia (XLSA); X-linked sideroblastic anemia with ataxia (ASAT)
GYPA	glycophorin A (MNS blood group)	Cell surface interactions at the vascular wall
MYO7A	myosin VIIA	The canonical retinoid cycle in rods (twilight vision)		Usher syndrome (US) Deafness, autosomal dominant Deafness, autosomal recessive
NUDT4	nudix hydrolase 4	Synthesis of pyrophosphates in the cytosol
PPP1R13L	protein phosphatase 1 regulatory subunit 13 like	Regulation of TP53 Activity through Association with Co-factors
RECK	reversion inducing cysteine rich protein with kazal motifs	Post-translational modification: synthesis of GPI-anchored proteins
SNRPN	small nuclear ribonucleoprotein polypeptide N	mRNA Splicing - Major Pathway		Prader-Willi and Angelman syndromes, including: Angelman syndrome (AS); Prader-Willi syndrome (PWS)

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