KEAP1 and CLU

Data Source:
BioGRID (two hybrid)

		KEAP1	CLU
Description		kelch like ECH associated protein 1	clusterin
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Actin Filament Inclusion Body Midbody Cul3-RING Ubiquitin Ligase Complex Centriolar Satellite	Extracellular Region Extracellular Space Nucleus Cytoplasm Mitochondrion Mitochondrial Inner Membrane Golgi Apparatus Cytosol Cytoskeleton Cell Surface Membrane Platelet Alpha Granule Lumen Protein-containing Complex Spherical High-density Lipoprotein Particle Chromaffin Granule Intracellular Membrane-bounded Organelle Synapse Perinuclear Region Of Cytoplasm Collagen-containing Extracellular Matrix Extracellular Exosome Cell Periphery Blood Microparticle Neurofibrillary Tangle Apical Dendrite Perinuclear Endoplasmic Reticulum Lumen
	Molecular Function	Protein Binding Transcription Factor Binding Identical Protein Binding Disordered Domain Specific Binding	Amyloid-beta Binding Signaling Receptor Binding Protein Binding ATPase Activity Ubiquitin Protein Ligase Binding Protein-containing Complex Binding Tau Protein Binding Low-density Lipoprotein Particle Receptor Binding Unfolded Protein Binding Chaperone Binding Misfolded Protein Binding
	Biological Process	In Utero Embryonic Development Ubiquitin-dependent Protein Catabolic Process Regulation Of Autophagy Viral Process Protein Ubiquitination Protein Deubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Oxidative Stress Cytoplasmic Sequestering Of Transcription Factor Negative Regulation Of DNA-binding Transcription Factor Activity Post-translational Protein Modification Regulation Of Epidermal Cell Differentiation Cellular Response To Interleukin-4	Cell Morphogenesis Microglial Cell Activation Release Of Cytochrome C From Mitochondria Immune Complex Clearance Platelet Degranulation Lipid Metabolic Process Complement Activation Complement Activation, Classical Pathway Response To Virus Positive Regulation Of Gene Expression Protein Import Antimicrobial Humoral Response Regulation Of Complement Activation Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Protein-containing Complex Assembly Central Nervous System Myelin Maintenance Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Cell Population Proliferation Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Reverse Cholesterol Transport Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Receptor-mediated Endocytosis Protein Stabilization Positive Regulation Of NF-kappaB Transcription Factor Activity Chaperone-mediated Protein Complex Assembly Response To Misfolded Protein Negative Regulation Of Cell Death Chaperone-mediated Protein Folding Microglial Cell Proliferation Protein Targeting To Lysosome Involved In Chaperone-mediated Autophagy Chaperone-mediated Protein Transport Involved In Chaperone-mediated Autophagy Negative Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Amyloid-beta Clearance Regulation Of Neuron Death Positive Regulation Of Neuron Death Positive Regulation Of Amyloid-beta Formation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Amyloid-beta Formation Regulation Of Neuronal Signal Transduction Positive Regulation Of Tau-protein Kinase Activity Positive Regulation Of Neurofibrillary Tangle Assembly Negative Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Cellular Response To Thapsigargin Negative Regulation Of Cellular Response To Tunicamycin Negative Regulation Of Amyloid Fibril Formation Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways		Ub-specific processing proteases Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Platelet degranulation Terminal pathway of complement Antimicrobial peptides Regulation of Complement cascade
Drugs		Dimethyl fumarate	Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Body mass index and waist-hip ratio (pleiotropy) ( 29868124) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908)	Alzheimer's disease ( 19734902 19734903 21627779 31473137) Alzheimer's disease (late onset) ( 21460841 30617256 24162737 28714976) Alzheimer's disease in APOE e4+ carriers ( 25778476) Alzheimer's disease in APOE e4- carriers ( 25778476) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or fasting insulin levels (pleiotropy) ( 30805717) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Family history of Alzheimer's disease ( 30617256) Lung adenocarcinoma ( 28604730) Lung cancer in ever smokers ( 28604730) Panic disorder ( 19165232) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656) Smoking behaviour (cigarettes smoked per day) ( 31089300) Smoking status (ever vs never smokers) ( 30643258) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		77 interacting genes: AK4 AMER1 ANKS1A ATG5 BAD BPTF C2orf68 CARD10 CAT CCNB1IP1 CDH1 CDK6 CLU COL1A1 COL2A1 CPEB2 CSNK2A1 CTTN CUL3 DPP3 EAF1 EGFR ERICH5 ETF1 FAM117B GLRX5 GPR151 GYPA HSP90AA1 HSP90AB1 ICAM1 IFIH1 IPO11 IQCC IRF1 KLHL2 KLHL3 KPNA6 LAMTOR5 LSM3 MAD2L1 MAPKBP1 MCM3 MCMBP MYO7A NFE2L2 NIBAN2 NTAQ1 NUDT4 NUP50 OXR1 PALB2 PAQR4 PDCD6IP PPP1R13L PRKAG1 PTMA RAF1 RECK RELA SMARCD1 SNRPN SQSTM1 STAP2 STK3 STK4 TBC1D7 TENT5A TERF1 TET2 TRIM15 UBC USP15 WDR83 WHRN ZNF121 ZSCAN32	50 interacting genes: APP BAG6 C7 C8B C9 CBY1 CD209 CLUAP1 CYP2E1 DISC1 ELN EPPIN FOS GRB2 HSPD1 IL24 KATNA1 KEAP1 KLF11 KNSTRN LEP LEPR LIG4 LRP2 LRP8 LYZ MAPK9 MDM2 MMP25 MSRB1 PAXIP1 PLXNA4 POLR1C PON1 PRNP RBBP8 RPL23 SRPK2 SYVN1 TGFBR1 TGFBR2 TNIK TREM2 TSC22D4 TTR UBC VHL VLDLR XRCC6 ZWINT
Entrez ID		9817	1191
HPRD ID		12079	01706
Ensembl ID		ENSG00000079999	ENSG00000120885
Uniprot IDs		A0A024R7C0 Q14145	P10909
PDB IDs		1U6D 1ZGK 2FLU 3VNG 3VNH 3ZGC 3ZGD 4CXI 4CXJ 4CXT 4IFJ 4IFL 4IFN 4IN4 4IQK 4L7B 4L7C 4L7D 4N1B 4XMB 5DAD 5DAF 5F72 5GIT 5NLB 5WFL 5WFV 5WG1 5WHL 5WHO 5WIY 5X54 6FFM 6FMP 6FMQ 6HWS 6LRZ 6ROG 6SP1 6SP4 6T7V 6T7Z 6TG8 6TYM 6TYP 6UF0 6V6Z 6W66 6W67 6W68 6W69 6WCQ
Enriched GO Terms of Interacting Partners?
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