KEAP1 - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Associated Diseases Hide
CPEB2	cytoplasmic polyadenylation element binding protein 2
CTTN	cortactin	RHO GTPases activate PAKs Clathrin-mediated endocytosis
CUL3	cullin 3	Degradation of DVL Hedgehog 'on' state Regulation of RAS by GAPs Neddylation RHOBTB2 GTPase cycle RHOBTB1 GTPase cycle RHOBTB3 ATPase cycle Antigen processing: Ubiquitination & Proteasome degradation
DPP3	dipeptidyl peptidase 3
EAF1	ELL associated factor 1	Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation
ERICH5	glutamate rich 5
ETF1	eukaryotic translation termination factor 1	Eukaryotic Translation Termination Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
FAM117B	family with sequence similarity 117 member B
GLRX5	glutaredoxin 5	Mitochondrial iron-sulfur cluster biogenesis	Erythropoietic porphyria (EP), including: Erythropoietic protoporphyria (EPP); Congenital erythropoietic porphyria (CEP); Gunther Disease; X-linked erythropoietic protoporphyria (XLEPP) Sideroblastic anemia, including: Pyridoxine-refractory autosomal recessive sideroblastic anemia (PRARSA); X-linked sideroblastic anemia (XLSA); X-linked sideroblastic anemia with ataxia (ASAT)
GPR151	G protein-coupled receptor 151
GYPA	glycophorin A (MNS blood group)	Cell surface interactions at the vascular wall
IFIH1	interferon induced with helicase C domain 1	DDX58/IFIH1-mediated induction of interferon-alpha/beta Ub-specific processing proteases Ovarian tumor domain proteases TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling	Type I diabetes mellitus
IPO11	importin 11
IQCC	IQ motif containing C
IRF1	interferon regulatory factor 1	Interferon gamma signaling Interferon alpha/beta signaling Factors involved in megakaryocyte development and platelet production
KLHL2	kelch like family member 2	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
KLHL3	kelch like family member 3	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
KPNA6	karyopherin subunit alpha 6
LAMTOR5	late endosomal/lysosomal adaptor, MAPK and MTOR activator 5	Macroautophagy MTOR signalling mTORC1-mediated signalling Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of PTEN gene transcription Amino acids regulate mTORC1
LSM3	LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated	mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease mRNA Splicing - Major Pathway

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