KEAP1 - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
GLRX5	glutaredoxin 5	Mitochondrial iron-sulfur cluster biogenesis		Erythropoietic porphyria (EP), including: Erythropoietic protoporphyria (EPP); Congenital erythropoietic porphyria (CEP); Gunther Disease; X-linked erythropoietic protoporphyria (XLEPP) Sideroblastic anemia, including: Pyridoxine-refractory autosomal recessive sideroblastic anemia (PRARSA); X-linked sideroblastic anemia (XLSA); X-linked sideroblastic anemia with ataxia (ASAT)
WHRN	whirlin			Usher syndrome (US) Deafness, autosomal recessive
AMER1	APC membrane recruitment protein 1	Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex		Osteopathia striata with cranial sclerosis
CAT	catalase	Detoxification of Reactive Oxygen Species Neutrophil degranulation Peroxisomal protein import Peroxisomal protein import FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	Fomepizole Cannabidiol Medical Cannabis Nabiximols	Acatalasia, including: Acatalasemia; Takahara's disease; Hypocatalasemia
ICAM1	intercellular adhesion molecule 1	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling	Natalizumab Hyaluronic acid Nafamostat	Allograft rejection
IFIH1	interferon induced with helicase C domain 1	DDX58/IFIH1-mediated induction of interferon-alpha/beta Ub-specific processing proteases Ovarian tumor domain proteases TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling		Type I diabetes mellitus
PALB2	partner and localizer of BRCA2	HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange		Fanconi anemia
SNRPN	small nuclear ribonucleoprotein polypeptide N	mRNA Splicing - Major Pathway		Prader-Willi and Angelman syndromes, including: Angelman syndrome (AS); Prader-Willi syndrome (PWS)
SQSTM1	sequestosome 1	NRIF signals cell death from the nucleus p75NTR recruits signalling complexes NF-kB is activated and signals survival PINK1-PRKN Mediated Mitophagy Interleukin-1 signaling Pexophagy		Paget's disease of bone and related disorders, including: ; Paget's disease of bone (PDB); Familial expansile osteolysis (FEO); Early-onset Paget's disease of bone (PDB2); Expansile skeletal hyperphosphatasia (ESH); Juvenile Paget's disease (JPD)
AK4	adenylate kinase 4	Interconversion of nucleotide di- and triphosphates
ANKS1A	ankyrin repeat and sterile alpha motif domain containing 1A
ATG5	autophagy related 5	Macroautophagy Macroautophagy PINK1-PRKN Mediated Mitophagy Receptor Mediated Mitophagy Negative regulators of DDX58/IFIH1 signaling
BAD	BCL2 associated agonist of cell death	Activation of BAD and translocation to mitochondria Activation of BAD and translocation to mitochondria BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members NRAGE signals death through JNK AKT phosphorylates targets in the cytosol Constitutive Signaling by AKT1 E17K in Cancer	Navitoclax
BPTF	bromodomain PHD finger transcription factor
C2orf68	chromosome 2 open reading frame 68
CARD10	caspase recruitment domain family member 10
CCNB1IP1	cyclin B1 interacting protein 1
CDK6	cyclin dependent kinase 6	Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Cyclin D associated events in G1 Regulation of RUNX1 Expression and Activity Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	Alvocidib (2S)-2-({6-[(3-Amino-5-chlorophenyl)amino]-9-isopropyl-9H-purin-2-yl}amino)-3-methyl-1-butanol Fisetin Palbociclib Ribociclib Abemaciclib
CLU	clusterin	Platelet degranulation Terminal pathway of complement Antimicrobial peptides Regulation of Complement cascade	Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
CPEB2	cytoplasmic polyadenylation element binding protein 2

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