Novel |
SLC5A5 |
solute carrier family 5 member 5 |
- Thyroxine biosynthesis
- Organic anion transporters
- Defective SLC5A5 causes thyroid dyshormonogenesis 1 (TDH1)
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- Iodine
- Potassium perchlorate
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- Thyroid dyshormonogenesis; Dyshormogenetic goiter
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Novel |
ADH5 |
alcohol dehydrogenase 5 (class III), chi polypeptide |
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- NADH
- Lauric acid
- 12-Hydroxydodecanoic Acid
- S-Hydroxymethyl Glutathione
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Novel |
ARPC1B |
actin related protein 2/3 complex subunit 1B |
- Regulation of actin dynamics for phagocytic cup formation
- Regulation of actin dynamics for phagocytic cup formation
- EPHB-mediated forward signaling
- RHO GTPases Activate WASPs and WAVEs
- RHO GTPases Activate WASPs and WAVEs
- FCGR3A-mediated phagocytosis
- FCGR3A-mediated phagocytosis
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- N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide
- (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one
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Novel |
BNIP3L |
BCL2 interacting protein 3 like |
- TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
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Novel |
CARM1 |
coactivator associated arginine methyltransferase 1 |
- RORA activates gene expression
- BMAL1:CLOCK,NPAS2 activates circadian gene expression
- PPARA activates gene expression
- PPARA activates gene expression
- Transcriptional activation of mitochondrial biogenesis
- Activation of gene expression by SREBF (SREBP)
- RMTs methylate histone arginines
- Transcriptional regulation of white adipocyte differentiation
- Regulation of lipid metabolism by PPARalpha
- Circadian Clock
- TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
- Estrogen-dependent gene expression
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Novel |
ERBIN |
erbb2 interacting protein |
- Signaling by ERBB2
- Downregulation of ERBB2 signaling
- Constitutive Signaling by Overexpressed ERBB2
- Drug-mediated inhibition of ERBB2 signaling
- Signaling by ERBB2 KD Mutants
- Resistance of ERBB2 KD mutants to trastuzumab
- Resistance of ERBB2 KD mutants to sapitinib
- Resistance of ERBB2 KD mutants to tesevatinib
- Resistance of ERBB2 KD mutants to neratinib
- Resistance of ERBB2 KD mutants to osimertinib
- Resistance of ERBB2 KD mutants to afatinib
- Resistance of ERBB2 KD mutants to AEE788
- Resistance of ERBB2 KD mutants to lapatinib
- Signaling by ERBB2 ECD mutants
- Signaling by ERBB2 TMD/JMD mutants
- Drug resistance in ERBB2 TMD/JMD mutants
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Novel |
LONP1 |
lon peptidase 1, mitochondrial |
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Novel |
PANX1 |
pannexin 1 |
- Electric Transmission Across Gap Junctions
- The NLRP3 inflammasome
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Novel |
RTN4R |
reticulon 4 receptor |
- Axonal growth inhibition (RHOA activation)
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Novel |
S1PR2 |
sphingosine-1-phosphate receptor 2 |
- G alpha (i) signalling events
- Lysosphingolipid and LPA receptors
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Novel |
SDC1 |
syndecan 1 |
- A tetrasaccharide linker sequence is required for GAG synthesis
- HS-GAG biosynthesis
- HS-GAG biosynthesis
- HS-GAG degradation
- Cell surface interactions at the vascular wall
- Syndecan interactions
- Syndecan interactions
- Defective B4GALT7 causes EDS, progeroid type
- Defective B3GAT3 causes JDSSDHD
- Defective EXT2 causes exostoses 2
- Defective EXT1 causes exostoses 1, TRPS2 and CHDS
- Defective B3GALT6 causes EDSP2 and SEMDJL1
- Other interleukin signaling
- Retinoid metabolism and transport
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Novel |
SENP1 |
SUMO specific peptidase 1 |
- SUMO is proteolytically processed
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Novel |
VAC14 |
VAC14 component of PIKFYVE complex |
- Synthesis of PIPs at the Golgi membrane
- Synthesis of PIPs at the Golgi membrane
- Synthesis of PIPs at the early endosome membrane
- Synthesis of PIPs at the early endosome membrane
- Synthesis of PIPs at the late endosome membrane
- Synthesis of PIPs at the late endosome membrane
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Novel |
ZNF177 |
zinc finger protein 177 |
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Novel |
ZNF266 |
zinc finger protein 266 |
- Generic Transcription Pathway
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EGFR |
epidermal growth factor receptor |
- Signaling by ERBB2
- Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
- Signaling by ERBB4
- SHC1 events in ERBB2 signaling
- SHC1 events in ERBB2 signaling
- PLCG1 events in ERBB2 signaling
- PIP3 activates AKT signaling
- Signaling by EGFR
- GRB2 events in EGFR signaling
- GAB1 signalosome
- SHC1 events in EGFR signaling
- EGFR downregulation
- GRB2 events in ERBB2 signaling
- PI3K events in ERBB2 signaling
- EGFR interacts with phospholipase C-gamma
- EGFR Transactivation by Gastrin
- Constitutive Signaling by Aberrant PI3K in Cancer
- Signal transduction by L1
- Constitutive Signaling by EGFRvIII
- Inhibition of Signaling by Overexpressed EGFR
- RAF/MAP kinase cascade
- ERBB2 Regulates Cell Motility
- PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
- ERBB2 Activates PTK6 Signaling
- Cargo recognition for clathrin-mediated endocytosis
- Clathrin-mediated endocytosis
- PTK6 promotes HIF1A stabilization
- Downregulation of ERBB2 signaling
- TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
- Extra-nuclear estrogen signaling
- NOTCH3 Activation and Transmission of Signal to the Nucleus
- HCMV Early Events
- Estrogen-dependent nuclear events downstream of ESR-membrane signaling
- Signaling by ERBB2 KD Mutants
- Signaling by ERBB2 ECD mutants
- Signaling by ERBB2 TMD/JMD mutants
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- Cetuximab
- Lidocaine
- Gefitinib
- Erlotinib
- Lapatinib
- Panitumumab
- Alvocidib
- IGN311
- Matuzumab
- Vandetanib
- Rindopepimut
- Canertinib
- Pelitinib
- Varlitinib
- AV-412
- S-{3-[(4-ANILINOQUINAZOLIN-6-YL)AMINO]-3-OXOPROPYL}-L-CYSTEINE
- PD-168393
- Afatinib
- Osimertinib
- Necitumumab
- Foreskin keratinocyte (neonatal)
- Depatuxizumab mafodotin
- Icotinib
- Neratinib
- Dacomitinib
- Fostamatinib
- Zalutumumab
- Brigatinib
- Olmutinib
- Zanubrutinib
- Abivertinib
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- Choriocarcinoma
- Gastric cancer
- Bladder cancer
- Oral cancer
- Glioma
- Laryngeal cancer
- Cervical cancer
- Esophageal cancer
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CDH1 |
cadherin 1 |
- Degradation of the extracellular matrix
- Degradation of the extracellular matrix
- Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
- Integrin cell surface interactions
- Apoptotic cleavage of cell adhesion proteins
- Adherens junctions interactions
- RHO GTPases activate IQGAPs
- InlA-mediated entry of Listeria monocytogenes into host cells
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- Gastric cancer
- Penile cancer
- Nasopharyngeal cancer
- Breast cancer
- Hepatocellular carcinoma
- Thyroid cancer
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COL1A1 |
collagen type I alpha 1 chain |
- GPVI-mediated activation cascade
- Collagen degradation
- Collagen degradation
- Extracellular matrix organization
- Collagen biosynthesis and modifying enzymes
- Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
- Assembly of collagen fibrils and other multimeric structures
- Cell surface interactions at the vascular wall
- Integrin cell surface interactions
- Integrin cell surface interactions
- Anchoring fibril formation
- Crosslinking of collagen fibrils
- Syndecan interactions
- Non-integrin membrane-ECM interactions
- ECM proteoglycans
- ECM proteoglycans
- Scavenging by Class A Receptors
- GP1b-IX-V activation signalling
- Platelet Adhesion to exposed collagen
- Platelet Adhesion to exposed collagen
- Platelet Aggregation (Plug Formation)
- MET activates PTK2 signaling
- RUNX2 regulates osteoblast differentiation
- Collagen chain trimerization
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- Collagenase clostridium histolyticum
- Halofuginone
- Clove oil
- Vonicog Alfa
- Von Willebrand Factor Human
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- Ehlers-Danlos syndrome (EDS), including: EDS classical type (EDS1/2); EDS hypermobility type (EDS3); EDS vascular type (EDS4); EDS kyphoscoliosis type (EDS6); EDS arthrochalasia type (EDS7A/7B); EDS dermatospraxis type (EDS7C); EDS autosomal recessive cardiac valvular form (EDSCV); EDS musculocontractural type (EDSMC); EDS progeroid form (EDSP); Tenascin-X deficiency (TNXD); Brittle cornea syndrome (EDS6B); EDS-like spondylocheiro dysplasia (SCD-EDS)
- Infantile cortical hyperostosis; Caffey disease
- Osteogenesis imperfecta
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COL2A1 |
collagen type II alpha 1 chain |
- Collagen degradation
- Collagen degradation
- Extracellular matrix organization
- Collagen biosynthesis and modifying enzymes
- Signaling by PDGF
- Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
- Assembly of collagen fibrils and other multimeric structures
- Integrin cell surface interactions
- Integrin cell surface interactions
- Non-integrin membrane-ECM interactions
- ECM proteoglycans
- ECM proteoglycans
- NCAM1 interactions
- MET activates PTK2 signaling
- Collagen chain trimerization
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- Collagenase clostridium histolyticum
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- Type II collagenopathies, including: Achondrogenesis II; Hypochondrogenesis; SED congenita; SMED Strudwick type; Kniest dysplasia; Spondyloperipheral dysplasia; Osteoarthritis with mild chondrodysplasia; Stickler syndrome 1; Platyspondylic skeletal dysplasia, Torrance type; Epiphyseal dysplasia, multiple, with myopia and deafness; Czech dysplasia
- Vitreoretinal degeneration, including: Stickler syndrome type I (STL1); Stickler syndrome type II (STL2); Snowflake vitreoretinal degeneration (SVD); Wagner syndrome 1 (WGN1); Knobloch syndrome (KNO); Enhanced S-cone syndrome (ESCS); Autosomal dominant vitreoretinochoroidopathy (ADVIRC)
- Osteoarthritis with mild chondrodysplasia
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MYO7A |
myosin VIIA |
- The canonical retinoid cycle in rods (twilight vision)
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- Usher syndrome (US)
- Deafness, autosomal dominant
- Deafness, autosomal recessive
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