ESR1 - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide
HSPA4	heat shock protein family A (Hsp70) member 4	Regulation of HSF1-mediated heat shock response	Phenethyl Isothiocyanate
HSPA8	heat shock protein family A (Hsp70) member 8	Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) Attenuation phase HSF1-dependent transactivation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis CHL1 interactions AUF1 (hnRNP D0) binds and destabilizes mRNA Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation mRNA Splicing - Major Pathway Clathrin-mediated endocytosis Protein methylation GABA synthesis, release, reuptake and degradation Lipophagy Chaperone Mediated Autophagy Late endosomal microautophagy	Dasatinib (2R,3R,4S,5R)-2-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol Copper Artenimol
ILF3	interleukin enhancer binding factor 3
ING1	inhibitor of growth family member 1
ISL1	ISL LIM homeobox 1	Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Regulation of expression of SLITs and ROBOs
ITGB3BP	integrin subunit beta 3 binding protein	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal NRIF signals cell death from the nucleus NRIF signals cell death from the nucleus Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
JUN	Jun proto-oncogene, AP-1 transcription factor subunit	Pre-NOTCH Transcription and Translation Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) FCERI mediated MAPK activation Activation of the AP-1 family of transcription factors Activation of anterior HOX genes in hindbrain development during early embryogenesis MAPK6/MAPK4 signaling TP53 Regulates Transcription of DNA Repair Genes Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Regulation of PTEN gene transcription Regulation of PTEN gene transcription Estrogen-dependent gene expression WNT5:FZD7-mediated leishmania damping	Adapalene Vinblastine Pseudoephedrine Irbesartan Arsenic trioxide LGD-1550
JUNB	JunB proto-oncogene, AP-1 transcription factor subunit	SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Interleukin-4 and Interleukin-13 signaling NGF-stimulated transcription NGF-stimulated transcription
JUND	JunD proto-oncogene, AP-1 transcription factor subunit	Estrogen-dependent gene expression NGF-stimulated transcription NGF-stimulated transcription
KAT5	lysine acetyltransferase 5	Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex DNA Damage/Telomere Stress Induced Senescence HATs acetylate histones HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Sensing of DNA Double Strand Breaks Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Resolution of D-loop Structures through Holliday Junction Intermediates Nonhomologous End-Joining (NHEJ) Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Estrogen-dependent gene expression	Coenzyme A S-Acetyl-Cysteine
KDM5A	lysine demethylase 5A	HDMs demethylate histones
KIF1A	kinesin family member 1A	COPI-dependent Golgi-to-ER retrograde traffic Kinesins	Adenosine-5'-[Beta, Gamma-Methylene]Triphosphate Phosphoaminophosphonic Acid-Adenylate Ester
KLF5	Kruppel like factor 5	Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of granulopoiesis
KLK5	kallikrein related peptidase 5	Formation of the cornified envelope Formation of the cornified envelope
KLK9	kallikrein related peptidase 9
KMT5B	lysine methyltransferase 5B	PKMTs methylate histone lysines
KRT18	keratin 18	Keratinization Formation of the cornified envelope
KRT19	keratin 19	Keratinization Formation of the cornified envelope
KRT8	keratin 8	Keratinization Formation of the cornified envelope	Tenecteplase Lanoteplase Copper
LARS1	leucyl-tRNA synthetase 1	Selenoamino acid metabolism Cytosolic tRNA aminoacylation	Leucine

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