Novel |
GTF2E1 |
general transcription factor IIE subunit 1 |
- HIV Transcription Initiation
- RNA Polymerase II HIV Promoter Escape
- Transcription of the HIV genome
- RNA Polymerase II Pre-transcription Events
- RNA polymerase II transcribes snRNA genes
- RNA polymerase II transcribes snRNA genes
- RNA Polymerase II Promoter Escape
- RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
- RNA Polymerase II Transcription Initiation
- RNA Polymerase II Transcription Initiation And Promoter Clearance
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Novel |
MRPL3 |
mitochondrial ribosomal protein L3 |
- Mitochondrial translation initiation
- Mitochondrial translation elongation
- Mitochondrial translation elongation
- Mitochondrial translation termination
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Novel |
MBD4 |
methyl-CpG binding domain 4, DNA glycosylase |
- Recognition and association of DNA glycosylase with site containing an affected pyrimidine
- Cleavage of the damaged pyrimidine
- Displacement of DNA glycosylase by APEX1
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Novel |
PCCB |
propionyl-CoA carboxylase subunit beta |
- Biotin transport and metabolism
- Defective HLCS causes multiple carboxylase deficiency
- Propionyl-CoA catabolism
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Novel |
GM2A |
GM2 ganglioside activator |
- Glycosphingolipid metabolism
- Neutrophil degranulation
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- Platelet Activating Factor
- Lauric acid
- Lpc-Ether
- Choline alfoscerate
- Myristic acid
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- GM2 gangliosidoses, including: Tay-Sachs disease (type I); Sandhoff disease (type II); Tay-Sachs disease AB variant
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Novel |
AADAC |
arylacetamide deacetylase |
- Phase I - Functionalization of compounds
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Novel |
ACP3 |
acid phosphatase 3 |
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- (2R,3R)-2,3-Dihydroxy-4-oxo-4-(propylamino)butanoic acid
- Alpha-Benzyl-Aminobenzyl-Phosphonic Acid
- Sipuleucel-T
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Novel |
AMOTL2 |
angiomotin like 2 |
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Novel |
CTPS1 |
CTP synthase 1 |
- Interconversion of nucleotide di- and triphosphates
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Novel |
UQCRC2 |
ubiquinol-cytochrome c reductase core protein 2 |
- Respiratory electron transport
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- 2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol
- 6-Hydroxy-5-undecyl-4,7-benzothiazoledione
- Azoxystrobin
- (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE
- (S)-famoxadone
- METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE
- 2-Nonyl-4-quinolinol 1-oxide
- Ubiquinone Q2
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ERBB2 |
erb-b2 receptor tyrosine kinase 2 |
- Signaling by ERBB2
- SHC1 events in ERBB2 signaling
- SHC1 events in ERBB2 signaling
- PLCG1 events in ERBB2 signaling
- PIP3 activates AKT signaling
- GRB7 events in ERBB2 signaling
- Downregulation of ERBB2:ERBB3 signaling
- GRB2 events in ERBB2 signaling
- GRB2 events in ERBB2 signaling
- PI3K events in ERBB2 signaling
- Constitutive Signaling by Aberrant PI3K in Cancer
- Sema4D induced cell migration and growth-cone collapse
- RAF/MAP kinase cascade
- ERBB2 Regulates Cell Motility
- PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
- ERBB2 Activates PTK6 Signaling
- Downregulation of ERBB2 signaling
- TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
- Constitutive Signaling by Overexpressed ERBB2
- Drug-mediated inhibition of ERBB2 signaling
- Signaling by ERBB2 KD Mutants
- Resistance of ERBB2 KD mutants to trastuzumab
- Resistance of ERBB2 KD mutants to sapitinib
- Resistance of ERBB2 KD mutants to tesevatinib
- Resistance of ERBB2 KD mutants to neratinib
- Resistance of ERBB2 KD mutants to osimertinib
- Resistance of ERBB2 KD mutants to afatinib
- Resistance of ERBB2 KD mutants to AEE788
- Resistance of ERBB2 KD mutants to lapatinib
- Signaling by ERBB2 ECD mutants
- Signaling by ERBB2 TMD/JMD mutants
- Drug resistance in ERBB2 TMD/JMD mutants
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- Trastuzumab
- Lapatinib
- IGN311
- Trastuzumab emtansine
- Varlitinib
- AV-412
- Pertuzumab
- Afatinib
- Tucatinib
- Tesevatinib
- Fostamatinib
- Brigatinib
- Margetuximab
- Zanubrutinib
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- Choriocarcinoma
- Pancreatic cancer
- Gastric cancer
- Bladder cancer
- Endometrial Cancer
- Ovarian cancer
- Cholangiocarcinoma
- Breast cancer
- Cervical cancer
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NCK1 |
NCK adaptor protein 1 |
- Downstream signal transduction
- Generation of second messenger molecules
- Regulation of actin dynamics for phagocytic cup formation
- Regulation of actin dynamics for phagocytic cup formation
- Nephrin family interactions
- DCC mediated attractive signaling
- DCC mediated attractive signaling
- Activation of RAC1
- VEGFA-VEGFR2 Pathway
- RHO GTPases Activate WASPs and WAVEs
- RHO GTPases Activate WASPs and WAVEs
- FCGR3A-mediated phagocytosis
- FCGR3A-mediated phagocytosis
- Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
- Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
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EFNB1 |
ephrin B1 |
- EPH-Ephrin signaling
- EPH-Ephrin signaling
- EPHB-mediated forward signaling
- EPHB-mediated forward signaling
- Ephrin signaling
- Ephrin signaling
- EPH-ephrin mediated repulsion of cells
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- Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss syndrome; Beare-Stevenson syndrome; Muenke craniosynostosis; Saethre-Chotzen syndrome; Craniosynostosis Boston type; Antley-Bixler syndrome; Carpenter syndrome; Craniofrontonasal dysplasia; Noonan syndrome; Baller-Gerold syndrome
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EFNB2 |
ephrin B2 |
- EPH-Ephrin signaling
- EPH-Ephrin signaling
- EPHB-mediated forward signaling
- EPHB-mediated forward signaling
- Ephrin signaling
- Ephrin signaling
- EPH-ephrin mediated repulsion of cells
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EPHB6 |
EPH receptor B6 |
- EPH-Ephrin signaling
- EPH-Ephrin signaling
- EPHB-mediated forward signaling
- EPHB-mediated forward signaling
- Ephrin signaling
- Ephrin signaling
- EPH-ephrin mediated repulsion of cells
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GRB10 |
growth factor receptor bound protein 10 |
- Signaling by SCF-KIT
- IRS activation
- Signal attenuation
- Insulin receptor signalling cascade
- RET signaling
- FLT3 Signaling
- Response of EIF2AK1 (HRI) to heme deficiency
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EFNA1 |
ephrin A1 |
- EPH-Ephrin signaling
- EPH-Ephrin signaling
- EPHA-mediated growth cone collapse
- EPHA-mediated growth cone collapse
- EPH-ephrin mediated repulsion of cells
- EPH-ephrin mediated repulsion of cells
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EFNA5 |
ephrin A5 |
- EPH-Ephrin signaling
- EPH-Ephrin signaling
- EPHA-mediated growth cone collapse
- EPHA-mediated growth cone collapse
- EPH-ephrin mediated repulsion of cells
- EPH-ephrin mediated repulsion of cells
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PRKCG |
protein kinase C gamma |
- Calmodulin induced events
- Disinhibition of SNARE formation
- Trafficking of GluR2-containing AMPA receptors
- G alpha (z) signalling events
- WNT5A-dependent internalization of FZD4
- Response to elevated platelet cytosolic Ca2+
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- Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
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PXN |
paxillin |
- GAB1 signalosome
- VEGFA-VEGFR2 Pathway
- Smooth Muscle Contraction
- Localization of the PINCH-ILK-PARVIN complex to focal adhesions
- Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
- PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
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