EPHB1 and MBD4

Data Source:
BioGRID (biochemical)

		EPHB1	MBD4
Description		EPH receptor B1	methyl-CpG binding domain 4, DNA glycosylase
Image
GO Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Cytosol Plasma Membrane Integral Component Of Plasma Membrane Dendrite Early Endosome Membrane Neuron Projection Receptor Complex Extracellular Exosome	Nucleus Nucleoplasm Nuclear Speck
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Activity Transmembrane-ephrin Receptor Activity Protein Binding ATP Binding	DNA Binding Satellite DNA Binding Endodeoxyribonuclease Activity Protein Binding Pyrimidine-specific Mismatch Base Pair DNA N-glycosylase Activity DNA N-glycosylase Activity
	Biological Process	Angiogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Axon Guidance Skeletal Muscle Satellite Cell Activation Peptidyl-tyrosine Phosphorylation Central Nervous System Projection Neuron Axonogenesis Neurogenesis Establishment Of Cell Polarity Retinal Ganglion Cell Axon Guidance Cell-substrate Adhesion Positive Regulation Of Kinase Activity Regulation Of JNK Cascade Protein Autophosphorylation Ephrin Receptor Signaling Pathway Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Positive Regulation Of Synapse Assembly Cell Chemotaxis Dendritic Spine Development Dendritic Spine Morphogenesis Neural Precursor Cell Proliferation Regulation Of ERK1 And ERK2 Cascade Regulation Of Neuron Death Negative Regulation Of Skeletal Muscle Satellite Cell Proliferation Negative Regulation Of Satellite Cell Differentiation	DNA Repair Response To Estradiol Depyrimidination
Pathways		EPH-Ephrin signaling EPH-Ephrin signaling EPHB-mediated forward signaling EPHB-mediated forward signaling Ephrin signaling Ephrin signaling EPH-ephrin mediated repulsion of cells	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Displacement of DNA glycosylase by APEX1
Drugs		Fostamatinib
Diseases
GWAS		Adult body size ( 32376654) Bitter beverage consumption ( 31046077) CV-A6-associated hand, foot, and mouth disease (severe vs mild) ( 32634583) Daytime sleep phenotypes ( 27126917) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383) Familial lung adenocarcinoma ( 29924316) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Iron status biomarkers (total iron binding capacity) ( 28334935) Mood instability ( 31168069) Neurofibrillary tangles ( 31497858) Small cell lung carcinoma ( 28604730) Visceral adipose tissue adjusted for BMI ( 22589738) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) Waist-hip ratio ( 28552196) Waist-to-hip ratio adjusted for BMI ( 28552196)	Diisocyanate-induced asthma ( 25918132) Systemic sclerosis (anti-topoisomerase-positive) ( 29293537) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		13 interacting genes: ACP1 EFNA1 EFNA5 EFNB1 EFNB2 EPHB6 ERBB2 GRB10 GRB2 MTDH NCK1 PRKCG PXN	15 interacting genes: CDCA2 CSNK2B DNMT3B FADD FAS HDAC1 KDM1A MLH1 NAT2 SIN3A SUV39H1 TRIM27 TRIM55 TRIM63 UHRF1
Entrez ID		2047	8930
HPRD ID		02790	04654
Ensembl ID		ENSG00000154928	ENSG00000129071
Uniprot IDs		P54762	O95243
PDB IDs		2DJS 2EAO 3ZFX 5MJA 5MJB 6UMW	2MOE 3IHO 4DK9 4E9E 4E9F 4E9G 4E9H 4EA4 4EA5 4LG7 4OFA 4OFE 4OFH 5CHZ
Enriched GO Terms of Interacting Partners?
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