EPHB1 and PCCB

Data Source:
BioGRID (affinity chromatography technology)

		EPHB1	PCCB
Description		EPH receptor B1	propionyl-CoA carboxylase subunit beta
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Cytosol Plasma Membrane Integral Component Of Plasma Membrane Dendrite Early Endosome Membrane Neuron Projection Receptor Complex Extracellular Exosome	Mitochondrion Mitochondrial Matrix Cytosol
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Activity Transmembrane-ephrin Receptor Activity Protein Binding ATP Binding	Propionyl-CoA Carboxylase Activity Protein Binding ATP Binding
	Biological Process	Angiogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Axon Guidance Skeletal Muscle Satellite Cell Activation Peptidyl-tyrosine Phosphorylation Central Nervous System Projection Neuron Axonogenesis Neurogenesis Establishment Of Cell Polarity Retinal Ganglion Cell Axon Guidance Cell-substrate Adhesion Positive Regulation Of Kinase Activity Regulation Of JNK Cascade Protein Autophosphorylation Ephrin Receptor Signaling Pathway Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Positive Regulation Of Synapse Assembly Cell Chemotaxis Dendritic Spine Development Dendritic Spine Morphogenesis Neural Precursor Cell Proliferation Regulation Of ERK1 And ERK2 Cascade Regulation Of Neuron Death Negative Regulation Of Skeletal Muscle Satellite Cell Proliferation Negative Regulation Of Satellite Cell Differentiation	Biotin Metabolic Process Short-chain Fatty Acid Catabolic Process
Pathways		EPH-Ephrin signaling EPH-Ephrin signaling EPHB-mediated forward signaling EPHB-mediated forward signaling Ephrin signaling Ephrin signaling EPH-ephrin mediated repulsion of cells	Biotin transport and metabolism Defective HLCS causes multiple carboxylase deficiency Propionyl-CoA catabolism
Drugs		Fostamatinib	Biotin Valine
Diseases			Propionic acidemia
GWAS		Adult body size ( 32376654) Bitter beverage consumption ( 31046077) CV-A6-associated hand, foot, and mouth disease (severe vs mild) ( 32634583) Daytime sleep phenotypes ( 27126917) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383) Familial lung adenocarcinoma ( 29924316) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Iron status biomarkers (total iron binding capacity) ( 28334935) Mood instability ( 31168069) Neurofibrillary tangles ( 31497858) Small cell lung carcinoma ( 28604730) Visceral adipose tissue adjusted for BMI ( 22589738) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) Waist-hip ratio ( 28552196) Waist-to-hip ratio adjusted for BMI ( 28552196)	Alanine transaminase levels ( 29403010) Autism spectrum disorder or schizophrenia ( 28540026) Coronary artery disease ( 33020668) Fibrinogen ( 20031576 23969696) Fibrinogen levels ( 28107422) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) Height ( 28552196 20881960) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Metabolic syndrome ( 31589552) Non-word reading ( 30741946) Schizophrenia ( 28991256 25056061 29483656) Systolic blood pressure ( 30224653) Total bilirubin levels ( 29403010) Triglyceride levels ( 32203549 32154731) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535)
Interacting Genes		13 interacting genes: ACP1 EFNA1 EFNA5 EFNB1 EFNB2 EPHB6 ERBB2 GRB10 GRB2 MTDH NCK1 PRKCG PXN	5 interacting genes: ACTN3 FBXL17 MTDH PCAT1 PCCA
Entrez ID		2047	5096
HPRD ID		02790	01982
Ensembl ID		ENSG00000154928	ENSG00000114054
Uniprot IDs		P54762	P05166
PDB IDs		2DJS 2EAO 3ZFX 5MJA 5MJB 6UMW
Enriched GO Terms of Interacting Partners?
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