DAXX - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Associated Diseases Hide
MKRN1	makorin ring finger protein 1	AKT phosphorylates targets in the cytosol Regulation of PTEN stability and activity Antigen processing: Ubiquitination & Proteasome degradation
MSANTD4	Myb/SANT DNA binding domain containing 4 with coiled-coils
MX1	MX dynamin like GTPase 1	ISG15 antiviral mechanism Interferon alpha/beta signaling
NECAB2	N-terminal EF-hand calcium binding protein 2
NSD3	nuclear receptor binding SET domain protein 3	PKMTs methylate histone lysines
PAX3	paired box 3	HATs acetylate histones	Alveolar rhabdomyosarcoma Craniofacial-deafness-hand syndrome Waardenburg syndrome (WS)
PAX5	paired box 5	RUNX1 regulates transcription of genes involved in BCR signaling	Lymphoplasmacytic lymphoma
PBXIP1	PBX homeobox interacting protein 1
PIBF1	progesterone immunomodulatory binding factor 1
PLAGL1	PLAG1 like zinc finger 1	TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	Transient neonatal diabetes mellitus (TNDM)
PNMA1	PNMA family member 1
RASSF1	Ras association domain family member 1		Non-small cell lung cancer Bladder cancer Nasopharyngeal cancer
RASSF3	Ras association domain family member 3
RIPK3	receptor interacting serine/threonine kinase 3	TICAM1, RIP1-mediated IKK complex recruitment RIP-mediated NFkB activation via ZBP1 TRIF-mediated programmed cell death TRP channels RIPK1-mediated regulated necrosis Regulation of necroptotic cell death TLR3-mediated TICAM1-dependent programmed cell death IKK complex recruitment mediated by RIP1 Microbial modulation of RIPK1-mediated regulated necrosis
RNF4	ring finger protein 4	Processing of DNA double-strand break ends Antigen processing: Ubiquitination & Proteasome degradation
RPL13	ribosomal protein L13	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
SENP2	SUMO specific peptidase 2	SUMO is proteolytically processed
SERBP1	SERPINE1 mRNA binding protein 1
SLC2A4	solute carrier family 2 member 4	Translocation of SLC2A4 (GLUT4) to the plasma membrane Cellular hexose transport Transcriptional regulation of white adipocyte differentiation
SNW1	SNW domain containing 1	Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells NOTCH1 Intracellular Domain Regulates Transcription NOTCH1 Intracellular Domain Regulates Transcription SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway mRNA Splicing - Major Pathway RUNX3 regulates NOTCH signaling RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription

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