DAXX - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide
HIPK3	homeodomain interacting protein kinase 3		Fostamatinib
HSF1	heat shock transcription factor 1	Regulation of HSF1-mediated heat shock response HSF1 activation Attenuation phase HSF1-dependent transactivation Aggrephagy	Bimoclomol
HSF4	heat shock transcription factor 4
KCTD4	potassium channel tetramerization domain containing 4
MAP3K5	mitogen-activated protein kinase kinase kinase 5	Oxidative Stress Induced Senescence Oxidative Stress Induced Senescence
MCRS1	microspherule protein 1	HATs acetylate histones UCH proteinases DNA Damage Recognition in GG-NER
MIPOL1	mirror-image polydactyly 1
MKRN1	makorin ring finger protein 1	AKT phosphorylates targets in the cytosol Regulation of PTEN stability and activity Antigen processing: Ubiquitination & Proteasome degradation
MSANTD4	Myb/SANT DNA binding domain containing 4 with coiled-coils
MX1	MX dynamin like GTPase 1	ISG15 antiviral mechanism Interferon alpha/beta signaling
NECAB2	N-terminal EF-hand calcium binding protein 2
NSD3	nuclear receptor binding SET domain protein 3	PKMTs methylate histone lysines
PBXIP1	PBX homeobox interacting protein 1
PIBF1	progesterone immunomodulatory binding factor 1
PNMA1	PNMA family member 1
PRMT1	protein arginine methyltransferase 1	RMTs methylate histone arginines TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Extra-nuclear estrogen signaling Estrogen-dependent gene expression	S-adenosyl-L-homocysteine
RASSF3	Ras association domain family member 3
RIPK3	receptor interacting serine/threonine kinase 3	TICAM1, RIP1-mediated IKK complex recruitment RIP-mediated NFkB activation via ZBP1 TRIF-mediated programmed cell death TRP channels RIPK1-mediated regulated necrosis Regulation of necroptotic cell death TLR3-mediated TICAM1-dependent programmed cell death IKK complex recruitment mediated by RIP1 Microbial modulation of RIPK1-mediated regulated necrosis
RNF4	ring finger protein 4	Processing of DNA double-strand break ends Antigen processing: Ubiquitination & Proteasome degradation
RPL13	ribosomal protein L13	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

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