Search Results for: DAXX

Novel Interactant Symbol Name
Associated Pathways
Binding Drugs
Associated Diseases
PRMT1 protein arginine methyltransferase 1
  • RMTs methylate histone arginines
  • TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
  • RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
  • Extra-nuclear estrogen signaling
  • Estrogen-dependent gene expression
  • S-adenosyl-L-homocysteine
PTEN phosphatase and tensin homolog
  • Synthesis of PIPs at the plasma membrane
  • Synthesis of IP3 and IP4 in the cytosol
  • Negative regulation of the PI3K/AKT network
  • Downstream TCR signaling
  • TP53 Regulates Metabolic Genes
  • PTEN Loss of Function in Cancer
  • Ub-specific processing proteases
  • Ovarian tumor domain proteases
  • Regulation of PTEN mRNA translation
  • Regulation of PTEN localization
  • Regulation of PTEN stability and activity
  • Transcriptional Regulation by MECP2
  • Phosphatidylethanolamine
  • Vulvar cancer
  • Prostate cancer
  • Endometrial Cancer
  • Glioma
  • Small cell lung cancer
  • Breast cancer
  • Hepatocellular carcinoma
  • Malignant melanoma
STAT3 signal transducer and activator of transcription 3
  • Interleukin-6 signaling
  • BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
  • Interleukin-7 signaling
  • Interleukin-7 signaling
  • Signaling by SCF-KIT
  • Signaling by cytosolic FGFR1 fusion mutants
  • Downstream signal transduction
  • Signalling to STAT3
  • Senescence-Associated Secretory Phenotype (SASP)
  • Signaling by Leptin
  • POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
  • Association of TriC/CCT with target proteins during biosynthesis
  • Transcriptional regulation of pluripotent stem cells
  • Interleukin-10 signaling
  • Interleukin-4 and Interleukin-13 signaling
  • PTK6 Activates STAT3
  • PTK6 Activates STAT3
  • Interleukin-20 family signaling
  • MET activates STAT3
  • MET activates STAT3
  • Interleukin-15 signaling
  • Interleukin-35 Signalling
  • Interleukin-9 signaling
  • Interleukin-37 signaling
  • Interleukin-23 signaling
  • Interleukin-23 signaling
  • Interleukin-27 signaling
  • Interleukin-21 signaling
  • Transcriptional regulation of granulopoiesis
  • Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
  • Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
  • Signaling by PDGFRA extracellular domain mutants
  • Growth hormone receptor signaling
  • ENMD-1198
  • Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
  • Oral cancer
UBC ubiquitin C
  • Translesion synthesis by REV1
  • Recognition of DNA damage by PCNA-containing replication complex
  • Translesion Synthesis by POLH
  • Activation of NF-kappaB in B cells
  • ISG15 antiviral mechanism
  • Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
  • Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
  • ER-Phagosome pathway
  • Downregulation of ERBB4 signaling
  • Spry regulation of FGF signaling
  • Downregulation of ERBB2:ERBB3 signaling
  • Budding and maturation of HIV virion
  • NOD1/2 Signaling Pathway
  • TICAM1, RIP1-mediated IKK complex recruitment
  • DDX58/IFIH1-mediated induction of interferon-alpha/beta
  • APC/C:Cdc20 mediated degradation of Cyclin B
  • Autodegradation of Cdh1 by Cdh1:APC/C
  • SCF-beta-TrCP mediated degradation of Emi1
  • APC/C:Cdc20 mediated degradation of Securin
  • APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
  • Cdc20:Phospho-APC/C mediated degradation of Cyclin A
  • Membrane binding and targetting of GAG proteins
  • Assembly Of The HIV Virion
  • APC-Cdc20 mediated degradation of Nek2A
  • Vpu mediated degradation of CD4
  • Vif-mediated degradation of APOBEC3G
  • EGFR downregulation
  • SCF(Skp2)-mediated degradation of p27/p21
  • Degradation of beta-catenin by the destruction complex
  • TCF dependent signaling in response to WNT
  • Downstream TCR signaling
  • NRIF signals cell death from the nucleus
  • p75NTR recruits signalling complexes
  • NF-kB is activated and signals survival
  • Regulation of activated PAK-2p34 by proteasome mediated degradation
  • NOTCH1 Intracellular Domain Regulates Transcription
  • Activated NOTCH1 Transmits Signal to the Nucleus
  • Activated NOTCH1 Transmits Signal to the Nucleus
  • Downregulation of TGF-beta receptor signaling
  • Downregulation of TGF-beta receptor signaling
  • TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
  • Downregulation of SMAD2/3:SMAD4 transcriptional activity
  • Downregulation of SMAD2/3:SMAD4 transcriptional activity
  • SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
  • SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
  • Separation of Sister Chromatids
  • Oxidative Stress Induced Senescence
  • Senescence-Associated Secretory Phenotype (SASP)
  • Oncogene Induced Senescence
  • Regulation of PLK1 Activity at G2/M Transition
  • Constitutive Signaling by NOTCH1 PEST Domain Mutants
  • Stimuli-sensing channels
  • Constitutive Signaling by NOTCH1 HD Domain Mutants
  • FCERI mediated NF-kB activation
  • Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
  • NOTCH2 Activation and Transmission of Signal to the Nucleus
  • Regulation of innate immune responses to cytosolic DNA
  • Glycogen synthesis
  • Autodegradation of the E3 ubiquitin ligase COP1
  • Deactivation of the beta-catenin transactivating complex
  • Myoclonic epilepsy of Lafora
  • ABC-family proteins mediated transport
  • Circadian Clock
  • TAK1 activates NFkB by phosphorylation and activation of IKKs complex
  • activated TAK1 mediates p38 MAPK activation
  • JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
  • AUF1 (hnRNP D0) binds and destabilizes mRNA
  • Asymmetric localization of PCP proteins
  • Degradation of AXIN
  • Degradation of DVL
  • Regulation of FZD by ubiquitination
  • PINK1-PRKN Mediated Mitophagy
  • N-glycan trimming in the ER and Calnexin/Calreticulin cycle
  • Regulation of TNFR1 signaling
  • TNFR1-induced NFkappaB signaling pathway
  • Hedgehog ligand biogenesis
  • Hh mutants are degraded by ERAD
  • Dectin-1 mediated noncanonical NF-kB signaling
  • CLEC7A (Dectin-1) signaling
  • Degradation of GLI1 by the proteasome
  • Degradation of GLI2 by the proteasome
  • GLI3 is processed to GLI3R by the proteasome
  • Hedgehog 'on' state
  • Hedgehog 'on' state
  • Negative regulation of FGFR1 signaling
  • Negative regulation of FGFR2 signaling
  • Negative regulation of FGFR3 signaling
  • Negative regulation of FGFR4 signaling
  • Translesion synthesis by POLK
  • Translesion synthesis by POLI
  • Termination of translesion DNA synthesis
  • Regulation of RAS by GAPs
  • TNFR2 non-canonical NF-kB pathway
  • Negative regulation of MAPK pathway
  • Regulation of necroptotic cell death
  • NIK-->noncanonical NF-kB signaling
  • Defective CFTR causes cystic fibrosis
  • MAP3K8 (TPL2)-dependent MAPK1/3 activation
  • HDR through Homologous Recombination (HRR)
  • MAPK6/MAPK4 signaling
  • UCH proteinases
  • UCH proteinases
  • Josephin domain DUBs
  • Ub-specific processing proteases
  • Ovarian tumor domain proteases
  • Metalloprotease DUBs
  • Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
  • Processing of DNA double-strand break ends
  • DNA Damage Recognition in GG-NER
  • Formation of Incision Complex in GG-NER
  • Gap-filling DNA repair synthesis and ligation in GG-NER
  • Dual Incision in GG-NER
  • Formation of TC-NER Pre-Incision Complex
  • Transcription-Coupled Nucleotide Excision Repair (TC-NER)
  • Dual incision in TC-NER
  • Gap-filling DNA repair synthesis and ligation in TC-NER
  • Fanconi Anemia Pathway
  • Regulation of TP53 Activity through Phosphorylation
  • Regulation of TP53 Degradation
  • Regulation of TP53 Activity through Methylation
  • Negative regulation of MET activity
  • CDT1 association with the CDC6:ORC:origin complex
  • Orc1 removal from chromatin
  • CDK-mediated phosphorylation and removal of Cdc6
  • Cyclin D associated events in G1
  • G2/M Checkpoints
  • Stabilization of p53
  • Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
  • Ubiquitin-dependent degradation of Cyclin D
  • PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
  • The role of GTSE1 in G2/M progression after G2 checkpoint
  • FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
  • Cargo recognition for clathrin-mediated endocytosis
  • Clathrin-mediated endocytosis
  • Downregulation of ERBB2 signaling
  • Synthesis of active ubiquitin: roles of E1 and E2 enzymes
  • Synthesis of active ubiquitin: roles of E1 and E2 enzymes
  • E3 ubiquitin ligases ubiquitinate target proteins
  • InlB-mediated entry of Listeria monocytogenes into host cell
  • InlB-mediated entry of Listeria monocytogenes into host cell
  • InlA-mediated entry of Listeria monocytogenes into host cells
  • RUNX1 regulates transcription of genes involved in differentiation of HSCs
  • Regulation of RUNX2 expression and activity
  • Regulation of RUNX2 expression and activity
  • Regulation of RUNX3 expression and activity
  • Regulation of PTEN localization
  • Regulation of PTEN stability and activity
  • Neddylation
  • ER Quality Control Compartment (ERQC)
  • Regulation of expression of SLITs and ROBOs
  • Regulation of expression of SLITs and ROBOs
  • NOTCH3 Activation and Transmission of Signal to the Nucleus
  • NOTCH3 Activation and Transmission of Signal to the Nucleus
  • TICAM1-dependent activation of IRF3/IRF7
  • TICAM1,TRAF6-dependent induction of TAK1 complex
  • Interleukin-1 signaling
  • Peroxisomal protein import
  • Peroxisomal protein import
  • Regulation of signaling by CBL
  • Endosomal Sorting Complex Required For Transport (ESCRT)
  • Iron uptake and transport
  • Negative regulators of DDX58/IFIH1 signaling
  • Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
  • IRAK1 recruits IKK complex
  • IKK complex recruitment mediated by RIP1
  • IRAK2 mediated activation of TAK1 complex
  • TRAF6-mediated induction of TAK1 complex within TLR4 complex
  • Negative regulation of NOTCH4 signaling
  • Chaperone Mediated Autophagy
  • Late endosomal microautophagy
  • Prevention of phagosomal-lysosomal fusion
  • Modulation by Mtb of host immune system
  • Alpha-protein kinase 1 signaling pathway
  • Aggrephagy
  • Aggrephagy
  • RAS processing
  • Pexophagy
  • Maturation of protein E
  • Maturation of protein E
  • Negative regulation of FLT3
  • FLT3 signaling by CBL mutants
  • TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
  • IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
  • IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
  • Amyloid fiber formation
  • Antigen processing: Ubiquitination & Proteasome degradation
  • N-Formylmethionine
AIRE autoimmune regulator
  • Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
AMOTL2 angiomotin like 2
  • Signaling by Hippo
ATRX ATRX chromatin remodeler
  • Inhibition of DNA recombination at telomere
  • Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations
  • Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations
  • Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
  • Thalassemia; Alpha thalassemia; Beta thalassemia; Alpha thalassemia, X-linked (ATRX)
  • Non-syndromic X-linked mental retardation
  • 46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
BTBD6 BTB domain containing 6
  • Neddylation
  • Antigen processing: Ubiquitination & Proteasome degradation
CALCOCO2 calcium binding and coiled-coil domain 2
CARD9 caspase recruitment domain family member 9
  • NOD1/2 Signaling Pathway
  • CLEC7A (Dectin-1) signaling
  • Chronic Mucocutaneous Candidiasis (CMC); Familial candidiasis (CANDF)
CARM1 coactivator associated arginine methyltransferase 1
  • RORA activates gene expression
  • BMAL1:CLOCK,NPAS2 activates circadian gene expression
  • PPARA activates gene expression
  • PPARA activates gene expression
  • Transcriptional activation of mitochondrial biogenesis
  • Activation of gene expression by SREBF (SREBP)
  • RMTs methylate histone arginines
  • Transcriptional regulation of white adipocyte differentiation
  • Regulation of lipid metabolism by PPARalpha
  • Circadian Clock
  • TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
  • Estrogen-dependent gene expression
CDCA7L cell division cycle associated 7 like
CENPC centromere protein C
  • Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
  • Separation of Sister Chromatids
  • Resolution of Sister Chromatid Cohesion
  • RHO GTPases Activate Formins
  • Deposition of new CENPA-containing nucleosomes at the centromere
  • Mitotic Prometaphase
  • EML4 and NUDC in mitotic spindle formation
CEP63 centrosomal protein 63
  • Regulation of PLK1 Activity at G2/M Transition
  • Loss of Nlp from mitotic centrosomes
  • Recruitment of mitotic centrosome proteins and complexes
  • Loss of proteins required for interphase microtubule organization from the centrosome
  • Recruitment of NuMA to mitotic centrosomes
  • Anchoring of the basal body to the plasma membrane
  • AURKA Activation by TPX2
CEP70 centrosomal protein 70
  • Regulation of PLK1 Activity at G2/M Transition
  • Loss of Nlp from mitotic centrosomes
  • Recruitment of mitotic centrosome proteins and complexes
  • Loss of proteins required for interphase microtubule organization from the centrosome
  • Recruitment of NuMA to mitotic centrosomes
  • Anchoring of the basal body to the plasma membrane
  • AURKA Activation by TPX2
CFLAR CASP8 and FADD like apoptosis regulator
  • TRAIL signaling
DKC1 dyskerin pseudouridine synthase 1
  • Telomere Extension By Telomerase
  • rRNA modification in the nucleus and cytosol
  • Hoyeraal-Hreidarsson syndrome
  • Dyskeratosis congenita (DC), including: X-linked dyskeratosis congenita (DKCX); Autosomal dominant dyskeratosis congenita (DKCA1); Autosomal recessive dyskeratosis congenita (DKCB1)
DMAP1 DNA methyltransferase 1 associated protein 1
  • HATs acetylate histones
ETS1 ETS proto-oncogene 1, transcription factor
  • Oncogene Induced Senescence
FAM9B family with sequence similarity 9 member B

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