CDKN2A - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Associated Diseases Hide
MCM10	minichromosome maintenance 10 replication initiation factor	Activation of ATR in response to replication stress Activation of the pre-replicative complex
MCM2	minichromosome maintenance complex component 2	Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state
MCM5	minichromosome maintenance complex component 5	Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state
MCM6	minichromosome maintenance complex component 6	Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state
MDM4	MDM4 regulator of p53	Oxidative Stress Induced Senescence Oncogene Induced Senescence Ub-specific processing proteases Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation Regulation of TP53 Activity through Methylation Stabilization of p53
MMRN1	multimerin 1	Platelet degranulation
NAT2	N-acetyltransferase 2	Acetylation
NCL	nucleolin	Major pathway of rRNA processing in the nucleolus and cytosol
NMI	N-myc and STAT interactor
NOP53	NOP53 ribosome biogenesis factor
NSD3	nuclear receptor binding SET domain protein 3	PKMTs methylate histone lysines
ORC4	origin recognition complex subunit 4	E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex	Patella dysplasias, including: Small patella syndrome (SPS); Nail-patella syndrome; Ear-patella-short statute syndrome
PEX19	peroxisomal biogenesis factor 19	ABC transporters in lipid homeostasis Class I peroxisomal membrane protein import Class I peroxisomal membrane protein import	Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)
PPP1R9B	protein phosphatase 1 regulatory subunit 9B
PTP4A3	protein tyrosine phosphatase 4A3
RASA1	RAS p21 protein activator 1	Downstream signal transduction EPHB-mediated forward signaling EPHB-mediated forward signaling VEGFR2 mediated cell proliferation Regulation of RAS by GAPs PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	RASA1-related disorders, including: Parkes-Weber slndrome; Capillary malformation-arteriovenous malformation (CM-AVM); Arteriovenous fistula (AVF)
RASSF1	Ras association domain family member 1		Non-small cell lung cancer Bladder cancer Nasopharyngeal cancer
RBM26	RNA binding motif protein 26
RIN2	Ras and Rab interactor 2	RAB GEFs exchange GTP for GDP on RABs	Macrocephaly, alopecia, cutis laxa, and scoliosis; MACS syndrome
RPS7	ribosomal protein S7	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Diamond-Blackfan anemia (DBA)

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